2019
DOI: 10.1161/atvbaha.119.312316
|View full text |Cite
|
Sign up to set email alerts
|

Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice

Abstract: Objective— TFEB (transcription factor EB) was recently reported to be induced by atheroprotective laminar flow and play an anti-atherosclerotic role by inhibiting inflammation in endothelial cells (ECs). This study aims to investigate whether TFEB regulates endothelial inflammation in diabetic db/db mice and the molecular mechanisms involved. Approach and Results— Endothelial denudat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

3
46
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
2
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 59 publications
(49 citation statements)
references
References 36 publications
3
46
0
Order By: Relevance
“…5A). NFκB signaling pathway plays important role in regulating macrophage polarization and associated in ammation [48]. In addition, miR-33 can sustain the in ammatory M1-like macrophage phenotype and inhibition of which can reduce plaque macrophage in ammation [20,41].…”
Section: Discussionmentioning
confidence: 99%
“…5A). NFκB signaling pathway plays important role in regulating macrophage polarization and associated in ammation [48]. In addition, miR-33 can sustain the in ammatory M1-like macrophage phenotype and inhibition of which can reduce plaque macrophage in ammation [20,41].…”
Section: Discussionmentioning
confidence: 99%
“…The mTOR-mediated phosphorylation negatively regulates TFEB nuclear translocation and activity [9]. It is of note that rapamycin analogues are therapeutically used as immuno-suppressants, and TFEB was also validated to have potential anti-inflammatory effect [10]. In this study, we further investigated whether mTOR-TFEB pathway plays a role in DIC-related inflammation.…”
Section: Introductionmentioning
confidence: 97%
“…Overexpression of TFEB gene in endothelial cells in mice increases angiogenesis and improves blood flow recovery after ischemic injury [21]. Animal experiments show that TFEB inhibits endothelial cell inflammation and reduces atherosclerosis [22,23]. Therefore, we postulated that altered TFEB levels may contribute to the onset of CAD and AMI.…”
Section: Introductionmentioning
confidence: 98%