Endothelial wall thickness, cardiorespiratory fitness and inflammatory markers in obese and non-obese adolescents

Silva, Larissa R.; Cavaglieri, Cláudia Regina; Lopes, Wendell Arthur; Pizzi, J.R.; Coelho‐e‐Silva, Manuel J.; Leite, Neiva

doi:10.1590/s1413-35552012005000133

Cited by 23 publications

(37 citation statements)

References 42 publications

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“…3,19 These relationships may explain the association between inflammation and cardiovascular risk markers observed in the sedentary group. 7,19 The relationship between inflammation and HDL-c was similar to previous research. 7,19 This lipoprotein is found to be inversely related to inflammatory markers.…”

Section: Discussionsupporting

confidence: 87%

“…7,19 The relationship between inflammation and HDL-c was similar to previous research. 7,19 This lipoprotein is found to be inversely related to inflammatory markers. 19 However, the absence of a relationship between these variables in the sports participation group was not predicted.…”

Section: Discussionsupporting

confidence: 87%

“…This study started in the second half of 2013 and has follow-up measures scheduled for the second half of 2014 (August/September). Before data collection, the minimum sample size was calculated 11 based on previous data about the expected relationship between cIMT and hsCRP (r = 0.28, power of 80%, alpha of 5%, and predicted loss of 20%), 7 which identified that a minimum of 118 participants were needed.…”

Section: Methodsmentioning

confidence: 99%

“…4,5 Its prolonged practice has been linked to the control the progression of intima-media thickness (IMT) in hypertensive adults 6 and also in healthy adolescents. 7,8 Recently, studies have reported that behavioral variables can modulate the relationship between the progression of artery IMT and its risk factors. 9,10 For instance, smoking exacerbates the relationship between age and the metabolic syndrome components and age and carotid IMT (cIMT) in young adults.…”

Section: Q5mentioning

confidence: 99%

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The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Cayres

Lira

Machado‐Rodrigues

et al. 2015

The Journal of Pediatrics

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Objective To analyze the relationship between inflammatory markers and the lipid profile, blood flow, and artery structure in prepubertal adolescents stratified according to sports practice. Study designThe sample was composed of 120 adolescents (57 boys and 63 girls) with a mean age of 11.7 AE 0.7 years (ranging from 11 to 13 years). Intima-media thickness (IMT) and blood flow were measured with ultrasonography. The lipid profile and high-sensitivity C-reactive protein were measured after the subjects had fasted for 12 hours overnight. Trunk fatness was measured by dual-energy x-ray absorptiometry. Organized sports participation was analyzed as a categorical variable. Biological maturation was determined via the age at peak height velocity.Results In the adjusted model, high-sensitivity C-reactive protein was significantly related to high-density lipopro- H igh-sensitivity C-reactive protein (hsCRP) is an acute-phase protein produced by the liver in response to interleukin-6, which is directly related to vascular inflammation.1,2 During the atherosclerotic process, hsCRP is associated with greater permeability of the intima layer through stimuli of intercellular/vascular cell adhesion molecules. hsCRP also acts in processes related to oxidation of lipoproteins in the vascular wall.2,3 Strategies to counteract inflammation status commonly include both pharmacologic and nonpharmacologic strategies. In the latter, lifestyle changes frequently are used, especially improved diet, giving up smoking, and practicing physical exercise. 4 Q5Indeed, physical exercise at moderate intensity plays an anti-inflammatory role. 4,5 Its prolonged practice has been linked to the control the progression of intima-media thickness (IMT) in hypertensive adults 6 and also in healthy adolescents. 7,8Recently, studies have reported that behavioral variables can modulate the relationship between the progression of artery IMT and its risk factors.9,10 For instance, smoking exacerbates the relationship between age and the metabolic syndrome components and age and carotid IMT (cIMT) in young adults. 10 In contrast, the same harmful effect related to age has been observed relating to physical inactivity.9 However, physical inactivity seems to exacerbate the relationship between cIMT Q6and overweight, blood pressure, and dyslipidemia in adults. 9The objective of the present study was to analyze the relationship between hsCRP and the lipid profile, blood flow, and artery IMT in prepubertal adolescents who were stratified according to their engagement in sports practice. It was hypothesized that inflammation would be positively and strongly related to cardiovascular/metabolic outcomes in inactive youth compared with the active ones, independent of body fatness and biological maturation.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Q5mentioning

confidence: 99%

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The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Cayres

Lira

Machado‐Rodrigues

et al. 2015

The Journal of Pediatrics

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“…Reduced aerobic fitness is very well documented in overweight and obese. [2,3] Greater VO 2 max is associated with lesser visceral fat and body mass index (BMI) and vice versa. Augmented aerobic fitness is supposed to improve blood pressure, cholesterol level, and status of weight in adolescents.…”

Section: Introductionmentioning

confidence: 99%

Does visceral fat affect aerobic fitness in Indian adolescents of 18-19 years' age group?

Parikh¹,

Shah²,

Singh³

2017

Natl J Physiol Pharm Pharmacol

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Background: Cardiovascular endurance tests are considered as one of the best methods for assessment of the individual's health. Reduced aerobic fitness is seen in overweight and obese. Aerobic fitness is also reduced in centrally obese individual. However, very less scientific documentation available on the effect of visceral fat on aerobic fitness in Indian adolescents. Aims and Objectives: The present study was undertaken to check the effect of visceral fat on aerobic fitness in Indian adolescents of 18-19 years of age group. Materials and Methods: Our study was conducted on 120 healthy, non-athletes' Indian adolescents (60 males and 60 females) of 18-19 years of age group after their voluntary written consent. Visceral fat was recorded by bioelectrical impedance technique using Omron HBF-302 body fat analyzer. All volunteers were categorized into two groups on the basis of their visceral fat. Volunteers with visceral fat 0-9 were categorized as a normal visceral fat group, and volunteers with visceral fat ≥10 were categorized as a high visceral fat group. Estimation of VO 2 max was done by treadmill exercise test following the standard Bruce protocol. Results: In high visceral fat Indian adolescents, VO 2 max by treadmill exercise test was significantly less as compared to the normal visceral fat group. In normal visceral fat male adolescents (n = 30), VO 2 max was 49.29 ± 7.81 ml/kg/min, and in high visceral fat male adolescents (n = 30), VO 2 max was 33.94 ± 6.75 ml/kg/min. (P < 0.001). Similarly, in normal visceral fat female Indian adolescents, VO 2 max was 47.85 ± 7.10 ml/kg/min, whereas in high visceral fat female adolescents (n = 30), VO 2 max was 29.68 ± 7.79 ml/kg/min. (P < 0.001). Conclusion: VO 2 max was significantly less in high visceral fat adolescents compared to normal visceral fat adolescents. Increased visceral fat is associated with reduced aerobic fitness in Indian adolescents.

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Sports participation improves metabolic profile in adolescents: ABCD growth study

Cayres‐Santos

Urban

Barbosa

et al. 2019

American J Hum Biol

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To analyze the impact of participation in sports with different cardiorespiratory fitness (CRF) demands on changes in metabolic and cardiovascular markers in adolescents. Longitudinal study with 12 months of follow-up (Analysis of Behaviors of Children During Growth [ABCD Growth Study]). Overall, 184 adolescents (age 15.6 ± 2.1) were classified according to sports participation: non-sport (control), low CRF sports, and high CRF sports. Metabolic outcomes were total cholesterol (TC) and its fractions, triacylglycerol (TG), glucose, insulin levels, and the insulin resistance index. Cardiovascular outcomes were arterial thickness (carotid and femoral [ultrasound]), blood pressure, and resting heart rate. Adolescents engaged in sports classified as high CRF demand presented a significant increase in HDL-c (1.2 mg/dL [95% CI: −0.5 to 3.0]) when compared to the non-sport group (−2.4 mg/dL [95%CI: −4.4 to −0.5]). Regular engagement in high CRF sports was significantly related to changes in TC (β = −0.027 [95%CI: −0.048 to −0.005]), HDL-c (β = 0.009 [95%CI: 0.001 to 0.019]), LDL-c (β = −0.032 [95%CI: −0.049 to −0.016]), and glucose (β = −0.017 [95%CI: −0.025 to −0.008]), while engagement in low CRF sports was related to changes in TG (β = −0.065 [95%CI: −0.112 to −0.019]). No significant relationships for cardiovascular parameters were observed in the low CRF group, but one significant relationship was found between high CRF sports and changes in SBP (β = −0.063 [95%CI: −0.117 to −0.009]). In conclusion, engagement in sports seems to be beneficial for improvements in metabolic and cardiovascular parameters in adolescents, mainly sports with higher CRF demand.

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Endothelial wall thickness, cardiorespiratory fitness and inflammatory markers in obese and non-obese adolescents

Cited by 23 publications

References 42 publications

The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

The Mediating Role of Physical Inactivity on the Relationship between Inflammation and Artery Thickness in Prepubertal Adolescents

Does visceral fat affect aerobic fitness in Indian adolescents of 18-19 years' age group?

Sports participation improves metabolic profile in adolescents: ABCD growth study

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