Endothelin-1 concentrations in cord blood of neonates with meconium-stained amniotic fluid

Gemelli, Marina; Manganaro, R; Mamì, C; Buemi, Michele; Paolata, Antonina; Marrone, Teresa; Marseglia, Lucia

doi:10.1515/jpm.2005.048

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Activation of ET-A receptor induces vasoconstriction while activation of ET-B leads to vasodilation. Serum ET-1/e levels are positively correlated with degree of PH (40, 41). Vascular remodeling processes are also resulting from “hyperdynamic circulation” and/or “forward flow” theory (42).…”

Section: Resultsmentioning

confidence: 99%

Portal Hypertension as Immune Mediate Disease

et al. 2014

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Context:Portal Hypertension (PH) is a progressive complication due to chronic liver disease. In addition to pathophysiologic changes in the micro-circulation, in PH are established fibrous tissue (periportal fibrous septal) and regenerative hyperplastic nodules (from micro- to macro-nodules) promoting hepatic architectural distortion.Evidence Acquisition:A literature search of electronic databases was undertaken for the major studies published from 1981 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the keywords: "portal hypertension, children, immune system, endocrine system, liver fibrosis".Results:It is believed that PH results from three “phenotype”: ischemia-reperfusion, involving nervous system (NS); edema and oxidative damage, involving immune system; inflammation and angiogenesis, involving endocrine system. However, its exact cause still underdiagnosed and unknown.Conclusions:PH is a dynamic and potentially reversible process. Researchers have tried to demonstrate mechanisms underlying PH and its related-complications. This review focuses on the current knowledge regarding the pathogenesis, and immune, endocrine-metabolic factors of disease. The strong positive association between immune system and development of PH could be efficient to identify non-invasive markers of disease, to modify prognosis of PH, and to development and application of specific and individual anti-inflammatory therapy.

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Section: Resultsmentioning

confidence: 99%