Endothelin-A Receptor Antagonist Treatment Improves the Periosteal Microcirculation After Hindlimb Ischemia and Reperfusion in the Rat

Wolfárd, Antal; Csaszar, J.; Gera, László; Petri, András; Simonka, János Aurél; Balogh, A; Boros, Mihály

doi:10.1038/sj.mn.7800167

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…The local effects may be variable, but microvascular disturbances are among the most frequent signs accompanying the ischemic insult in the periosteum. 4 Although several lines of evidence have suggested that IPC can effectively influence the perfusion of different organs, 5,6 the periosteal microcirculatory response in this condition is as yet largely undefined. Accordingly, our primary aim was to assess the degree of local microcirculatory protection that can be achieved by IPC in a rat model of experimental limb ischemia-reperfusion (I-R) using intravital fluorescence microscopic (IVM) examination of the periosteum.…”

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confidence: 99%

Ischemic limb preconditioning downregulates systemic inflammatory activation

Szabó

Varga

Keresztes

et al. 2008

Journal Orthopaedic Research

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We examined local and systemic antiinflammatory consequences of ischemic preconditioning (IPC) in a rat model of limb ischemia-reperfusion (I-R) by characterizing the leukocyte-endothelial interactions in the periosteum and the expression of adhesion molecules playing a role in leukocyte-mediated inflammatory processes. IPC induction (2 cycles of 10 min of complete limb ischemia and 10 min of reperfusion) was followed by 60 min of ischemia/180 min of reperfusion or sham-operation. Data were compared with those on animals subjected to I-R and sham-operation. Neutrophil leukocyte-endothelial cell interactions (intravital videomicroscopy), intravascular neutrophil activation (CD11b expression changes by flow cytometry), and soluble and tissue intercellular adhesion molecule-1 (ICAM-1; ELISA and immunohistochemistry, respectively) expressions were assessed. I-R induced enhanced leukocyte rolling and adherence in the periosteal postcapillary venules after 120 and 180 min of reperfusion. This was associated with a significantly enhanced CD11b expression (by $80% and 72%, respectively) and moderately increased soluble and periosteal ICAM-1 expressions. IPC prevented the I-R-induced increases in leukocyte adherence and CD11b expression without influencing the soluble and tissue ICAM-1 levels. The results show that limb IPC exerts not only local, but distant antiinflammatory effects through significant modulation of neutrophil recruitment. ß

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confidence: 99%

Ischemic limb preconditioning downregulates systemic inflammatory activation

Szabó

Varga

Keresztes

et al. 2008

Journal Orthopaedic Research

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Receptor‐Mediated Events in the Microcirculation

Watts¹,

Kanagy²,

Lombard³

2008

Comprehensive Physiology

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Temporal profile of microvascular disturbances in rat tibial periosteum following closed soft tissue trauma

Schaser

Zhang

Haas

et al. 2003

Langenbeck's Archives of Surgery

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Isolated CSTI in absence of a fracture exerts long-lasting disturbances in periosteal microcirculation, suggesting a delayed temporal profile in manifestation of CSTI-induced periosteal microvascular dysfunction and inflammation. These observations may have therapeutic implications in terms of preserving periosteal integrity and considering the interaction of skeletal muscle damage and periosteal microvascular injury during management of musculoskeletal trauma.

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Endothelin-A Receptor Antagonist Treatment Improves the Periosteal Microcirculation After Hindlimb Ischemia and Reperfusion in the Rat

Abstract: ET-1 plays a major role in microvascular dysfunction in the periosteum during reperfusion. The ET-1-ET-A receptor system might be an important target for tissue salvage therapy in transplantation surgery.

Cited by 6 publications

References 21 publications

Ischemic limb preconditioning downregulates systemic inflammatory activation

Ischemic limb preconditioning downregulates systemic inflammatory activation

Receptor‐Mediated Events in the Microcirculation

Temporal profile of microvascular disturbances in rat tibial periosteum following closed soft tissue trauma

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