Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors

Pawsey, J.; Lansley, Alison B.; Lethem, Mike

doi:10.1016/j.pupt.2011.05.008

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…No significant effect was detected during this exposure. This concentration of DMSO also proved innocuous to ciliary activity (Pawsey et al, 2011).…”

Section: Discussionmentioning

confidence: 91%

The effect of ingredients commonly used in nasal and inhaled solutions on the secretion of mucus in vitro

Ayoub

Lethem

Lansley

2021

International Journal of Pharmaceutics

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“…No significant effect was detected during this exposure. This concentration of DMSO also proved innocuous to ciliary activity (Pawsey et al, 2011).…”

Section: Discussionmentioning

confidence: 91%

The effect of ingredients commonly used in nasal and inhaled solutions on the secretion of mucus in vitro

Ayoub

Lethem

Lansley

2021

International Journal of Pharmaceutics

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“…For example, airway ciliated cells obtained from patients with chronic sinusitis, and mice exposed to longterm tobacco gas treatment, exhibited lower CBF compared to those obtained from normal airway epithelia (Simet et al, 2010;Li et al, 2014). Additionally, ciliated cells exposed to extracellular signaling molecules, such as interferon-γ, and interleukin (IL)-13 and -17, during their differentiation process demonstrated altered cilia structure and motility (Laoukili et al, 2001;Pawsey et al, 2011;Jiao et al, 2016). ASCs secrete various growth factors and cytokines, including VEGF, HGF, and IL-10 (Rehman et al, 2004;Zaragosi et al, 2006;Kilroy et al, 2007;Salgado et al, 2010), and the secretome of ASCs is considered beneficial for regeneration of injured tissues by virtue of its paracrine and anti-inflammatory effects (Marfia et al, 2015;Chang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cilia Function in Rat Trachea Reconstructed Using Collagen Sponge Scaffold Seeded with Adipose Tissue‐Derived Stem Cells

Nakamura

Katsuno

Tateya

et al. 2019

The Anatomical Record

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The tracheal lumen is essential for conducting air to the lung alveoli and for voice production. However, patients with severe tracheal stenosis and malignant tumors invading the trachea often require tracheal resection. Recently, various reported tissue engineering methods for tracheal reconstruction show that regeneration of ciliated epithelium in the reconstructed areas, as well as preservation of the luminal structure is possible. However, only few studies report on the mucociliary transport function in reconstructed tracheae. We investigated mucociliary transport function within rat tracheal epithelium, reorganized after autologous adipose tissue‐derived stem cell (ASC) transplantation. Rat ASCs were expanded in culture, and then seeded in a collagen sponge, which was physically supported with a polypropylene framework. The ASC‐seeded collagen sponge was transplanted into the rat tracheal defect. We then examined the motility and transport function of cilia generated in the transplanted area using ciliary beat frequency (CBF) and microsphere movement analyses. Our data suggested that autologous ASC transplantation promoted ciliogenesis, consistent with previous reports. The CBF analysis revealed that motility of the cilia generated in the ASC group was comparable to that observed in the normal rat tracheal epithelium. Transport function in the ASC group was higher than that in the control group. These data suggested that autologous ASC transplantation increased ciliated cells in the reconstructed area without significantly disrupting cilia motility, thereby promoting transport function regeneration. Autologous ASC transplantation is expected to be beneficial in morphological and functional regeneration of tracheal epithelium. Anat Rec, 303:471–477, 2020. © 2019 American Association for Anatomy

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Bronchial epithelium as a target for innovative treatments in asthma

Gras

Chanez

Vachier

et al. 2013

Pharmacology & Therapeutics

113

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Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors

Cited by 3 publications

References 46 publications

The effect of ingredients commonly used in nasal and inhaled solutions on the secretion of mucus in vitro

The effect of ingredients commonly used in nasal and inhaled solutions on the secretion of mucus in vitro

Evaluation of Cilia Function in Rat Trachea Reconstructed Using Collagen Sponge Scaffold Seeded with Adipose Tissue‐Derived Stem Cells

Bronchial epithelium as a target for innovative treatments in asthma

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