Endothelin-Induced c-fos Expression in the Rat Forebrain.

Kurokawa, Kiyoshi; Yamada, Hisao; Ochi, Junzo

doi:10.1267/ahc.30.51

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…These observations and our results suggest that ET-1 is involved not only in axodendrosomatic, but also in axoaxonic neural transmission. In the hypothalamic and thalamic area, the distribution of immunopositive neurons is essentially the same as the neuronal distribution of c-Fos triggered by intracerebroventricular injection of ET-1 (Kurokawa et al, 1997;Yamada and Kurokawa, 1993).…”

Section: Discussionmentioning

confidence: 82%

“…Therefore, this antibody recognized ET-AR but not MBP. In addition, there was no inconsistency between the distribution of immunopositive neurons and that of radiolabeled ET-1 binding sites (Bolger et al, 1992;Jones et al, 1989;Koseki et al, 1989;Neuser et al, 1991) or that of the sites of action analyzed by c-Fos expression studies (Kurokawa et al, 1997). Further discussion of sites of ET's action will follow.…”

Section: Discussionmentioning

confidence: 91%

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Topographical distribution of neurons containing endothelin type A receptor in the rat brain

1997

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Endothelin (ET) was originally identified as a vasoactive peptide biosynthesized in vascular endothelial cells. Because ET has also been found in the brain as a neuropeptide, it has been thought to belong to the group of brain-vascular peptide hormones. To date, type A and type B receptors for ET have been found. To elucidate the topographic distribution of type A receptor (ET-AR) in the brain, we raised a specific antibody to the C-terminal (64 amino acids) peptide of rat ET-AR and immunostained rat brain sections with this antibody. Immunoreactivity for ET-AR was detected in neuronal cell bodies and also in the many proximal and some distal parts of their fibers. Nerve cell bodies containing strong ET-AR-immunoreactivity were distributed in the lateral part of the reticular formation, the nucleus of the solitary tract and its surrounding area, the dorsal midline area and medial longitudinal fasciculus, the subependymal layer of the fourth ventricular roof, the caudolateral area of the pontine tegmentum, the locus coeruleus, the rostral pontine area of the lateral reticular formation, the retrorubral area, the substantia nigra, the ventral tegmental area, the periventricular region lateral to the rostral mesencephalic aqueduct and caudal third ventricle, the arcuate hypothalamic nucleus, the caudomedial area of the zona incerta, the periventricular hypothalamic nucleus, the parvocellular portion of the paraventricular hypothalamic nucleus, and the periglomerular region of the olfactory bulb. In addition, the Purkinje cells of the cerebellar cortex, the nerve cells in the mesencephalic trigeminal nucleus, and the magnocellular neurons of the supraoptic and paraventricular hypothalamic nuclei showed weak immunoreactivity. The distribution of highly ET-AR-immunoreactive neurons is quite similar to that ofcatecholamine neurons.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 91%

Topographical distribution of neurons containing endothelin type A receptor in the rat brain

1997

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“…The free-floating sections were treated with 0.3% H2O2 in PBS for 3 hr at room temperature followed by washing with PBS containing 0.25% TritonX-100 (PBST) according to the previously described immunohistochemical method [19,41]. Then they were successively incubated in: (i) primary antibody to c-Fos (rabbit polyclonal, 1:2000; Ab-2: Oncogene Science.…”

Section: Immunohistochemistry For C-fosmentioning

confidence: 99%

Association of Pressure Induced Hypertension with Specific Area of Ventrolateral Surface of Medulla Oblongata and Catecholamine Neurons.

Ichida

Yamada

Kurokawa

et al. 2001

Acta Histochem. Cytochem

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The rostral ventrolateral medulla (RVLM) is considered to be a major center for the regulation of sympathetic and cardiovascular activities. Several clinical studies have indicated a possible causal relationship between vasculoneural contact of the RVLM and essential hypertension. We previously reported that pulsatile compression of the ventral surface of the unilateral RVLM with a pulsating probe in anesthetized (with urethane) and artificially ventilated rats elevates arterial pressure, heart rate, and sympathetic nerve activity [28]. However, we have not investigated how and what kind of neurons are activated by compression. Therefore, we performed compression experiments in rats and examined the expression of c-fos, a marker of neuronal activation. The data indicate that after the compression of the ventral surface of the RVLM, c-fos mRNA was increased in the rostral and caudal ventrolateral medulla and the number of neurons containing specifically induced Fos-protein was considerably larger. They also suggest that the Fos-positive neurons also contain tyrosine hydroxylase, indicating that mechanical pressure (compression)-stimulated neural excitation occurred in the A1/C1 catecholamine-neurons and the specific area in the ventral surface of the RVLM is sensitive to compression.

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“…Besides the initial conception that ET is a vasoconstrictor peptide, ET is thought to have various physiological functions in the mammalian body [23]. We propose that ET belongs to the group of "brain vascular peptide hormones" because of its two major biological functions, i.e., regulation of neural transmission and vascular tonus [22,23] Consecutive studies in our laboratory elucidated that ET exists in many organs, i.e., the brain [6,7,21], the lacrimal gland [12], the submandibular gland and the lung [5], and the gastrointestinal tract [8], as well as the cardiovascular system [13].…”

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confidence: 99%

Immunohistochemical and in situ Hybridization Studies on Endothelin in the Rat Eye.

Teramura

Yamada

Kani

et al. 1997

Acta Histochem. Cytochem

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Endothelin-Induced c-fos Expression in the Rat Forebrain.

Cited by 5 publications

References 21 publications

Topographical distribution of neurons containing endothelin type A receptor in the rat brain

Topographical distribution of neurons containing endothelin type A receptor in the rat brain

Association of Pressure Induced Hypertension with Specific Area of Ventrolateral Surface of Medulla Oblongata and Catecholamine Neurons.

Immunohistochemical and in situ Hybridization Studies on Endothelin in the Rat Eye.

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