Endothelium-dependent and independent vasorelaxation induced by an n-butanolic fraction of bark of Scutia buxifolia Reiss (Rhamanaceae)

Silva, Rita de C.V.de A.F. Da; Crestani, Sandra; Souza, Priscila de; Boligon, Alexandra Augusti; Athayde, Margareth Linde; Santos, Adair Roberto Soares; Marques, Maria Consuelo Andrade; Kassuya, Cândida Aparecida Leite; Silva-Santos, José Eduardo da

doi:10.1016/j.jep.2012.03.045

Cited by 23 publications

(7 citation statements)

References 15 publications

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“…Scutia buxifolia Reissek (Rhamnaceae), popularly known in Brazil as “coronilha”, is native tree from South America, with a dispersion area that comprises Rio Grande do Sul State in Brazil, and the countries Argentina and Uruguay. In these regions, an aqueous infusion prepared with stem bark of S. buxifolia has been described and widely used in folk medicine for cardiotonic, diuretic and antihypertensive properties 20 , 21 . Phytochemical screening of S. buxifolia fractions revealed the presence of cyclopeptide alkaloids, steroids, polyphenols and flavonoids 22 , 23 , 24 , 25 .…”

Section: Introductionmentioning

confidence: 99%

Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Boligon

Freitas

Brum

et al. 2014

Acta Pharmaceutica Sinica B

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Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P<0.001 and P<0.0001) and dose-dependent increase in sulfhydryl groups (NPSH) levels, catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, the administration of ceSb reversed the increase in lipid peroxidation produced by ethanol. The protective effect of the extract could be attributed to antioxidant compounds present in the ceSb, such as flavonoids and phenolic acids, which were quantified by HPLC. Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. These results indicate that S. buxifolia could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.

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Section: Introductionmentioning

confidence: 99%

Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Boligon

Freitas

Brum

et al. 2014

Acta Pharmaceutica Sinica B

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“…It is a native plant from South America, with a dispersion that include Rio Grande do Sul state in Brazil, Argentina and Uruguay, where is popularly used as cardiotonic, antihypertensive and diuretic (Wasicky et al, 1964;Da Silva et al, 2012). This plant has shown to contain four classes of biologically active compounds, namely phenolic compounds (gallic, caffeic and chlorogenic acids), flavonoids (quercetin, quercitrin, isoquercitrin and rutin), alkaloids (scutianines A-M), and triterpenes (b-sitosterol, stigmasterol and lupeol) (Boligon et al, 2009a(Boligon et al, , 2010(Boligon et al, , 2012aMaldaner et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of Scutia buxifolia against the honeybee pathogen Paenibacillus larvae

Boligon

Brum

Zadra

et al. 2013

Journal of Invertebrate Pathology

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“…Scutia buxifolia, vulgarmente conhecida como "coronilha", é uma planta medicinal bastante usada na medicina popular como diurética, cardiotônica e hipotensora 15 .…”

Section: Resultsunclassified

Efeito Do Extrato Aquoso De Scutia Buxifolia Sobre Conteúdo Sérico De Albumina E Peso Corporal De Ratos

Freitas

Jesus

Araldi³

et al. 2015

Saúde (Sta. Maria)

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Efeito do extrato aquoso de Scutia buxifolia sobre conteúdo sérico de albumina e peso corporal de ratos RESUMO Scutia buxifolia é uma planta usada no tratamento de doenças cardíacas. No entanto, seus efeitos tóxicos no fígado são pouco conhecidos. Ratos Wistar (n=32) foram divididos em 4 grupos: controle e os tratados com 100, 200 e 400 mg do extrato aquoso liofilizado de S. buxifolia (EASB) / kg de peso corporal diariamente, durante 30 dias. O sangue dos animais foi coletado no 15º e 30º dia de experimento para a realização da dosagem de albumina sérica. As amostras foram centrifugadas a 3000 rpm durante 15 minutos. Este estudo teve por objetivo investigar os efeitos hepatotóxicos de EASB através do peso corporal, da massa úmida hepática e do conteúdo sérico de albumina. O EASB não altera os parâmetros analisados no presente estudo. Dessa forma, o extrato não foi tóxico nas doses usadas no ensaio.

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Endothelium-dependent and independent vasorelaxation induced by an n-butanolic fraction of bark of Scutia buxifolia Reiss (Rhamanaceae)

Cited by 23 publications

References 15 publications

Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Antimicrobial activity of Scutia buxifolia against the honeybee pathogen Paenibacillus larvae

Efeito Do Extrato Aquoso De Scutia Buxifolia Sobre Conteúdo Sérico De Albumina E Peso Corporal De Ratos

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