“…To this end, Pseudomonas aeruginosa is an important opportunistic gram-negative bacterium often associated with sepsis syndrome and poor outcome, particularly among patients with impaired immune responses and hospitalized patients (3,5,6,31). P. aeruginosa sepsis syndrome is characterized by profound vasodilation in skeletal muscles, which harbor the largest proportion of resistance arterioles in the peripheral circulation (4,8,13,22,29,32,38,48), that leads to intractable hypotension (1,2,9,12,28). A growing body of experimental evidence suggests that P. aeruginosa lipopolysaccharide (LPS), a macromolecular glycolipid component of bacterial wall (11,18,35), plays an important role in the pathophysiology of this response (2,9,11,12,18).…”