Endothelium-Dependent Vasodilatory and Hypotensive Effects of Crotalaria Sessiliflora L. in Rats

Koh, Sang Bum; Kang, Myung‐Hwa; Kim, Tae Su; Park, Hee Woon; Park, Chun Geon; Seong, Yeon Hee; Seong, Ha Jung

doi:10.1248/bpb.30.48

Cited by 12 publications

(6 citation statements)

References 23 publications

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“…Its vasodilatory effect could also be a result of regulating Ca 2+ levels (Kamkaew et al, 2011 ). A similar mechanism was also suggested for the vasorelaxant effect of an extract of Crotalaria sessiliflora (0.5–5 mg/ml) on rat thoracic aortic rings, where removal of endothelium, extracellular Ca 2+ or inhibition with L-NAME abolished the relaxation of this conduit artery (Koh et al, 2007 ; Table 2 ). Euphorbia humifusa also elicited a vasodilatory effect on phenylephrine-induced contractions in rat aortic rings by modulating NO and Ca 2+ levels (Wang et al, 2013 ; Table 2 ).…”

Section: Other Less-studied Plants With Hypotensive Activitiessupporting

confidence: 55%

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

2016

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Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to treat and manage cardiovascular disease (CVD) is on the rise. This is the second part of our comprehensive review where we discuss the mechanisms of plants and herbs used for the treatment and management of high blood pressure. Similar to the first part, PubMed and ScienceDirect databases were utilized, and the following keywords and phrases were used as inclusion criteria: hypertension, high blood pressure, herbal medicine, complementary and alternative medicine, endothelial cells, nitric oxide (NO), vascular smooth muscle cell (VSMC) proliferation, hydrogen sulfide, nuclear factor kappa-B (NF-κB), oxidative stress, and epigenetics/epigenomics. Each of the aforementioned keywords was co-joined with plant or herb in question, and where possible with its constituent molecule(s). This part deals in particular with plants that are used, albeit less frequently, for the treatment and management of hypertension. We then discuss the interplay between herbs/prescription drugs and herbs/epigenetics in the context of this disease. The review then concludes with a recommendation for more rigorous, well-developed clinical trials to concretely determine the beneficial impact of herbs and plants on hypertension and a disease-free living.

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Section: Other Less-studied Plants With Hypotensive Activitiessupporting

confidence: 55%

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

2016

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“…NO is a crucial mediator in endothelial vasodilator function, which is synthesized from the terminal guanidino nitrogen of L-arginine by NOS enzymes [17]. Substantial evidence has shown that NO-mediated relaxation of several substances or plant extracts in rat aortic rings [18,19,20], so we decided to investigate the involvement of endothelial NOS (eNOS) in DA -induced pulmonary artery rings relaxation. Pulmonary artery rings were pretreated with L-NAME (10 −4 M) for 30 min before being pre-contracted with PE.…”

Section: Resultsmentioning

confidence: 99%

Dehydroabietic Acid Isolated from Commiphora opobalsamum Causes Endothelium-Dependent Relaxation of Pulmonary Artery via PI3K/Akt-eNOS Signaling Pathway

et al. 2014

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Commiphora opobalsamum is a Traditional Chinese Medicine used to treat traumatic injury, mainly by relaxing blood vessels. In this study, two diterpenes, dehydroabietic acid (DA) and sandaracopimaric acid (SA) were obtained from it by a bioassay-guided approach using isolated rat pulmonary artery rings. The structures of the two compounds were elucidated by spectroscopic methods (IR, 1 H-and 13 C-NMR, HR-ESI-MS). Both DA and SA reduced the contraction of phenylephrine-induced pulmonary arteries in a concentration-dependent manner, and endothelium contributed greatly to the vasodilatory effect of DA. This effect of DA was attenuated by N G -Nitro-L-arginine methyl ester (L-NAME, an eNOS inhibitor). Meanwhile, DA increased nitric oxide (NO) production, along with the increase of phosphorylation level of eNOS and Akt in endothelial cells. LY294002 (a PI3K inhibitor) could reverse this effect, which suggested the endothelial PI3K/Akt pathway involved in the mechanism underlying DA-induced relaxation of pulmonary artery. This work provided evidence of vasorelaxant substances in OPEN ACCESSMolecules 2014, 19 8504Commiphora opobalsamum and validated that PI3K/Akt-eNOS pathway was associated with DA-induced pulmonary artery vasodilation.

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“…Moreover, vasoreactivity is a basic, important phenomenon that directly influences arteries of the circulatory system. Therefore, many researchers have investigated the vasorelaxant effects of various plant extracts as hypotensive agents by using aortic rings [22][23][24] . The endothelium plays key roles in the maintenance of vascular architecture and function, including vascular tone, by regulating the underlying smooth muscle layer through the release of both endothelium-derived relaxing factors, such as nitric oxide (NO), prostaglandins, and endothelium-derived hyperpolarizing factor (EDHF), and vasoconstriction factors [25] .…”

Section: Discussionmentioning

confidence: 99%

Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta

et al. 2016

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Aim: Ginsenosides are considered to be the major pharmacologically active ginseng constituents, whereas 20(S)-protopanaxadiol [20(S)-PPD] is the active metabolite of ginsenosides in gut. In this study we investigated the effect of 20(S)-PPD on isolated rat thoracic aortas as well as its vasorelaxant mechanisms. Methods: Aortic rings with or without endothelium were prepared from Wistar rats and suspended in organ-chambers. The changes in tension of the preparations were recorded through isometric transducers connected to a data acquisition system. The aortic rings were precontracted with phenylephrine (PE, 1 µmol/L) or high-K + (80 mmol/L).

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Endothelium-Dependent Vasodilatory and Hypotensive Effects of Crotalaria Sessiliflora L. in Rats

Cited by 12 publications

References 23 publications

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

Dehydroabietic Acid Isolated from Commiphora opobalsamum Causes Endothelium-Dependent Relaxation of Pulmonary Artery via PI3K/Akt-eNOS Signaling Pathway

Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta

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