Endothelium-derived nitric oxide enhances the effect of intraaortic balloon pumping on diastolic coronary flow

Toyota, Eiji; Goto, Masami; Nakamoto, Hiroshi; Ebata, Jun; Tachibana, Hideki; Hiramatsu, Osamu; Ogasawara, Yasuo; Kajiya, Fumihiko

doi:10.1016/s0003-4975(99)00156-3

Cited by 13 publications

(16 citation statements)

References 23 publications

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“…The isobaric changes (diameter increase and stiffness reduction) in intact IA during IABP could only be explained by a VSM relaxation, probably associated with a blood flow‐induced endothelium‐dependent response, and related to changes in shear stress. In agreement with this, it was previously shown that the endothelium‐derived nitric oxide contributes to blood flow‐mediated coronary vasodilatation during IABP (11). In addition, we previously found that IABP results in an increase in the aortic distensibility and in a reduction in its Z C (CF increase), which could be associated with changes in the aortic blood flow and shear stress (7).…”

Section: Discussionsupporting

confidence: 82%

“…Changes in the peripheral arteries during IABP would be expected, as the balloon placed in the thoracic aorta interacts with the arterial wall and causes changes in the arterial system wave pattern, repetitive variations in central and peripheral pressure and flow pulsatility, and increases (at each inflation) in peripheral blood flow (1,8,9).About the latter, in vivo experiments from our laboratory (unpublished data) and in vitro and in vivo experiments from other authors evidenced that the inflation of the intraaortic balloon results in an increase in the central (upstream) and peripheral (downstream) blood flow and in changes in blood flow profiles (10,11). Therefore, changes in shear stress over a substantial area of the endothelium of the peripheral arteries would be expected during IABP.…”

mentioning

confidence: 79%

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The Endothelium Modulates the Arterial Wall Mechanical Response to Intra‐Aortic Balloon Counterpulsation: In Vivo Studies

Bia¹,

Cabrera-Fischer²,

Zócalo³

et al. 2011

Artificial Organs

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Intra-aortic balloon pump (IABP) benefits could depend on variations in the cardiovascular biomechanical properties associated with blood flow-induced endothelium-dependent changes. However, if IABP results in changes in the peripheral artery biomechanics and if the endothelium plays a role in these potential changes remains unknown. The aim of this study is to characterize acute IABP effects on peripheral artery biomechanics in control and acute heart failure (AHF) states and the role of the endothelium in IABP effects on peripheral artery biomechanics. Pressure and diameter were recorded in sheep (n= 7) iliac arteries (IAs), before and during 1:2 IABP, during four states: (i) control with intact IA; (ii) AHF with intact IA; (iii) control with de-endothelialized (DE) (mechanical rubbing) IA; and (iv) AHF with DE IA. Arterial distensibility, elastic modulus, and conduit function (CF) (1/characteristic impedance) were calculated. The results of this study include: (i) during control conditions, IABP resulted in intact IA dilatation, stiffness reduction, and CF increase; (ii) AHF induction determined a reduction in intact IA diameter and CF, and a stiffness increase. These changes reverted during IABP; (iii) the increase in IA stiffness observed after DE remained unchanged during IABP; (iv) in DE IA, AHF did not result in diameter or stiffness changes; and (v) IABP during AHF did not associate changes in diameter or stiffness in the DE IA. In conclusion, during control and AHF states, IABP results in IA dilatation and stiffness reduction. The integrity of the endothelial layer would be critical for the IABP-associated changes in IA biomechanics.

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 79%

The Endothelium Modulates the Arterial Wall Mechanical Response to Intra‐Aortic Balloon Counterpulsation: In Vivo Studies

Bia¹,

Cabrera-Fischer²,

Zócalo³

et al. 2011

Artificial Organs

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“…23 Bia and colleagues 24 and Cabrera-Fischer and colleagues 25 showed that the IABP has a direct vasodilative effect on the smooth muscle cells. A direct endotheliumdependent vasoactive effect has also been shown on small and medium arterioles 26 and at a microvascular level. 18 According to these peripheral effects of IABP, the lower ISVR in group V of our study suggested maintenance during the weaning period of the vasodilative effect of the balloon, with more pronounced vascular effects with the volume-deflation weaning method.…”

Section: Discussionmentioning

confidence: 90%

How should I wean my next intra-aortic balloon pump? Differences between progressive volume weaning and rate weaning

Santini

Amoncelli

Campanella

et al. 2013

The Journal of Thoracic and Cardiovascular Surgery

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“…In a canine model, IABP augmented coronary blood flow by dilating coronary arterioles in diastole [80]. Inhibition of endotheliumderived NO markedly attenuated these vasodilatory effects.…”

Section: Mechanical Stresses and No In Coronary Circulationmentioning

confidence: 91%

Plasma detection of NO by a catheter

Goto

Mochizuki

2008

Med Biol Eng Comput

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Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been employed to evaluate endothelial function or NO bioavailability. However, a growing body of evidences suggests limitations of the indirect methods for evaluation of NO bioavailability. In years, it has been considered that NO is immediately oxidized or inactivated in blood stream. However, recent studies suggest that NO remain active in blood stream, causing remote biological response. Therefore, measuring plasma NO concentration directly in the circulation will contribute to clarify the kinetics and physiological roles of NO and to evaluate endothelial function. In this article, the measurement of plasma NO concentration using a newly developed catheter-type NO sensor will be described.

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Endothelium-derived nitric oxide enhances the effect of intraaortic balloon pumping on diastolic coronary flow

Cited by 13 publications

References 23 publications

The Endothelium Modulates the Arterial Wall Mechanical Response to Intra‐Aortic Balloon Counterpulsation: In Vivo Studies

The Endothelium Modulates the Arterial Wall Mechanical Response to Intra‐Aortic Balloon Counterpulsation: In Vivo Studies

How should I wean my next intra-aortic balloon pump? Differences between progressive volume weaning and rate weaning

Plasma detection of NO by a catheter

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