Endotoxemia, nutrition, and cardiometabolic disorders

Kallio, Katariina; Hätönen, Katja A.; Lehto, Markku; Salomaa, Veikko; Männistö, Satu; Pussinen, Pirkko J.

doi:10.1007/s00592-014-0662-3

Cited by 113 publications

(104 citation statements)

References 35 publications

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“…Higher circulating LPS levels were associated with an increased risk of type 2 diabetes [25], metabolic syndrome [25], and coronary heart disease [26] in humans. A chronic subcutaneous infusion of low-dose LPS-induced glucose intolerance, insulin resistance, and increased adiposity in mice [27], and thus, chronic exposure to low levels of LPS may be causally related to metabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, RYGB or duodenal switch has been reported to decrease plasma lipopolysaccharide (LPS) levels in obese human subjects with or without type 2 diabetes [24]. Increased plasma LPS levels were associated with incident type 2 diabetes [25], metabolic syndrome [25], and coronary heart disease [26] in humans. In mice, a chronic subcutaneous infusion of low-dose LPS produced glucose intolerance, insulin resistance, and obesity, which was associated with an increased expression of inflammatory genes in the liver, fat, and muscles [27].…”

Section: Introductionmentioning

confidence: 99%

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Ileal Transposition Decreases Plasma Lipopolysaccharide Levels in Association with Increased L Cell Secretion in Non-obese Non-diabetic Rats

Lee

Cho

2015

OBES SURG

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ileal Transposition Decreases Plasma Lipopolysaccharide Levels in Association with Increased L Cell Secretion in Non-obese Non-diabetic Rats

Lee

Cho

2015

OBES SURG

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“…Inflammation mediators, such as lipopolysaccharide and cytokines, may spread systemically promoting cardiometabolic disorders (Pussinen et al 2007;Pussinen et al 2011;Lockhart et al 2012;Schenkein and Loos 2013;Kallio et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death

et al. 2015

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Periodontitis, the main cause of tooth loss in the middle-aged and elderly, associates with the risk of atherosclerotic vascular disease. The objective was to study the capability of the number of missing teeth in predicting incident cardiovascular diseases (CVDs), diabetes, and all-cause death. The National FINRISK 1997 Study is a Finnish population-based survey of 8,446 subjects with 13 y of follow-up. Dental status was recorded at baseline in a clinical examination by a trained nurse, and information on incident CVD events, diabetes, and death was obtained via national registers. The registered CVD events included coronary heart disease events, acute myocardial infarction, and stroke. In Cox regression analyses, having ≥5 teeth missing was associated with 60% to 140% increased hazard for incident coronary heart disease events (P < 0.020) and acute myocardial infarction (P < 0.010). Incident CVD (P < 0.043), diabetes (P < 0.040), and death of any cause (P < 0.019) were associated with ≥9 missing teeth. No association with stroke was observed. Adding information on missing teeth to established risk factors improved risk discrimination of death (P = 0.0128) and provided a statistically significant net reclassification improvement for all studied end points. Even a few missing teeth may indicate an increased risk of CVD, diabetes, or all-cause mortality. When individual risk factors for chronic diseases are assessed, the number of missing teeth could be a useful additional indicator for general medical practitioners.

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“…Perturbation of the microbiota composition, also known as dysbiosis, has been observed in obesity, partly due to a strong decrease in the bacterial diversity [4]. In addition, the gram-negative cell wall component Lipopolysaccharide (LPS) translocation might induce metabolic endotoxemia, chronic low-grade inflammation, and ultimately insulin resistance [5,6]. This fact is also related to metabolic syndrome, and eventually to gastroesophageal reflux and esophagitis.…”

Section: Introductionmentioning

confidence: 99%

“…

years, probiotics have been shown to have a beneficial effect on obesity and insulin resistance [8,6].

…”

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confidence: 99%

Successful Evolution of a Patient with Obesity, Metabolic Syndrome and Severe Gastro esophageal Reflux after Probiotic Intake

Vázquez¹

2015

AOWMC

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Endotoxemia, nutrition, and cardiometabolic disorders

Abstract: A high serum LPS activity is strongly associated with cardiometabolic disorders, which supports the role of bacterial infections and immune response in their etiology.

Cited by 113 publications

References 35 publications

Ileal Transposition Decreases Plasma Lipopolysaccharide Levels in Association with Increased L Cell Secretion in Non-obese Non-diabetic Rats

Ileal Transposition Decreases Plasma Lipopolysaccharide Levels in Association with Increased L Cell Secretion in Non-obese Non-diabetic Rats

Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death

Successful Evolution of a Patient with Obesity, Metabolic Syndrome and Severe Gastro esophageal Reflux after Probiotic Intake

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