1999
DOI: 10.1111/j.1574-695x.1999.tb01336.x
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Endotoxin in blood and tissue in the sudden infant death syndrome

Abstract: Although the explanation for sudden infant death syndrome (SIDS) remains unknown, an increasing body of evidence now exists to suggest a possible role for bacterial toxins in the aetiology, and a number of investigators have considered that endotoxaemia could explain some of the associated features. Following the development of an animal model which confirmed that endotoxaemia could be detected after death, we studied endotoxin levels in blood and tissue samples taken at autopsy from SIDS infants, child contro… Show more

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Cited by 29 publications
(3 citation statements)
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“…A number of lines of evidence have led to the investigation of candidate genes related to infection and inflammation: (1) increased SIDS incidence in ethnic groups with high prevalences of infectious diseases [review in Blackwell et al, 2005]; (2) postmortem findings of bacterial infection before death [Morris et al, 2006]; (3) blood endotoxin levels in SIDS infants with evidence of inflammation [Crawley et al, 1999]; and (4) evidence of slight upper airway infection before death in about half of SIDS victims [Arnestad et al, 2001].…”
Section: Infection/inflammation Genes In Sidsmentioning
confidence: 99%
“…A number of lines of evidence have led to the investigation of candidate genes related to infection and inflammation: (1) increased SIDS incidence in ethnic groups with high prevalences of infectious diseases [review in Blackwell et al, 2005]; (2) postmortem findings of bacterial infection before death [Morris et al, 2006]; (3) blood endotoxin levels in SIDS infants with evidence of inflammation [Crawley et al, 1999]; and (4) evidence of slight upper airway infection before death in about half of SIDS victims [Arnestad et al, 2001].…”
Section: Infection/inflammation Genes In Sidsmentioning
confidence: 99%
“…There is a significant relationship between endotoxin levels in the blood and signs of inflammation in infants dying of SIDS (5). In addition, SIDS is more prevalent in populations in which infections are common, in association with influenza A outbreaks, and during winter months, when viral infections are prominent (6,7).…”
mentioning
confidence: 99%
“…A multitude of epidemiological and laboratory studies supporting this theory has subsequently been published, and summarized in a special issue of the FEMS Immunology and Medical Microbiology [14]. Among other candidates, extraintestinal endotoxin has been found elevated in SIDS [15]; at least where there were signs of inflammation in tissue [16]. Indeed, there seems to be a consumption of endotoxin IgG and triggering of endotoxin IgM in SIDS cases [17].…”
Section: Introductionmentioning
confidence: 99%