Endotoxin removal by end-line filters

Vanhaecke, Estelle; Muynck, C. De; Remon, Jean‐Paul; Colardyn, Francis

doi:10.1128/jcm.27.12.2710-2712.1989

Cited by 15 publications

(4 citation statements)

References 7 publications

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“…The affinity of LPS to adsorb on surfaces also is applied in filters for LPS removal from liquids. 13 As ubiquitous molecules, LPS are present on most surfaces and are difficult to remove from there with ordinary methods (see review in Ref. 1).…”

Section: Discussionmentioning

confidence: 99%

Surface endotoxin contamination and hemocompatibility evaluation of materials

et al. 2008

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To evaluate the blood compatibility of new materials, a clear distinction between properties of the materials and effects due to surface contamination by adsorbed endotoxins is essential. This study compares direct contact approaches and elution methods with water, organic solvents, nonionic, and zwitterionic detergents for determination of surface-adsorbed endotoxin by the limulus amoebocyte lysate (LAL) test and determines the blood compatibility of various surfaces with controlled endotoxin contamination in vitro. The LAL test in direct contact with an endotoxin-contaminated surface was concluded to be not practicable for most devices and its sensitivity showed a high dependence on surface characteristics. Among the elution methods, 0.2% Tween-20 showed most stable elution characteristics and appears therefore preferable. Biological reactions at in vitro blood exposure were found to be only minimally influenced by adsorbed endotoxin during the time window of 2 h, allowing for a straightforward discrimination between materials and endotoxin-dependent reactions.

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Section: Discussionmentioning

confidence: 99%

Surface endotoxin contamination and hemocompatibility evaluation of materials

et al. 2008

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“…The first stage is intended to produce the first filtrate, the product is subjected to repeated ultrafiltration, and the secondary filtrate is used as the end product. However, it should be taken into account that if the solution being depyrogenated contains low MW compounds (a buffer, a solution of amino acids, nucleotides, short peptides), endotoxins can be separated by ultrafiltration, using filters with cut-offs of 10 to 20 kDa; however, if the protein has a molecular weight similar to that of the endotoxin, ultrafiltration is unsuitable for separation of the endotoxin [15][16][17].…”

Section: Depyrogenating Membranesmentioning

confidence: 99%

Polymer Membranes in Medicine and Pharmaceutics

Fedotov¹,

Timakova

Тарасов³

et al. 2012

Eur Chem Tech J

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This review covers the main problems and basic principles of the use of various membranes in medicine and pharmacy. Developments in the field of sterilizing, bacteriostatic and bactericidal membranes and membranes for pyrogen-free water preparing are considered. An analysis of the scientific literature in this research area are identified. The main ways of development of this area, as well as an analysis of properties of membranes from different manufacturers for use in the medical and pharmaceutical industries are given. Their advantages and disadvantages are considered. It is shown that the main criterion for sterilizing membranes is the pore size, which should be no less than 0.1 microns. The most commonly used materials for sterilizing membranes are PTFE, polyamide and polysulfone. Review of methods for bacteriostatic and bactericidal membranes showed that there are different prospective modification methods of widely used membranes. Examples of some membranes modifications with inorganic and organic substances are considered. It is shown that the most effective modifying agents are chitosan and silver compounds. The mechanism of action of the ions and silver nanoparticles on bacterial cells is shown. A comparison of the effectiveness of distillation and membrane filtration processes for the preparation of water for injection is given. The ultra- and nanofiltration membranes used for pyrogen-free water preparing are described. New data about the properties of charged membranes are given. It is shown that the use of positively charged membranes for pyrogen-free water preparing is perspective, because it works by sieve and adsorption mechanism.

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“…1,6,7 In-line filtration effectively removes particles, air bubbles and endotoxin in clinical practice, and thus it is potentially able to reduce phlebitis associated with short peripheral venous cannulation (SPVC). [8][9][10][11] Nevertheless, the costs related with in-line filters might burden their clinical use.…”

Section: Introductionmentioning

confidence: 99%

In-line filtration reduced phlebitis associated with peripheral venous cannulation: Focus on cost-effectiveness and patients’ perspectives

et al. 2019

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Background: In a previous trial, in-line filtration significantly prevented postoperative phlebitis associated with short peripheral venous cannulation. This study aims to describe the cost-effectiveness of in-line filtration in reducing phlebitis and examine patients’ perception of in-hospital vascular access management with and without in-line filtration. Methods: We analysed costs associated with in-line filtration: these data were prospectively recorded during the previous trial. Furthermore, we performed a follow-up for all the 268 patients enrolled in this trial. Among these, 213 patients responded and completed 6 months after hospital discharge questionnaires evaluating the perception of and satisfaction with the management of their vascular access. Results: In-line filtration group required 95.60€ more than the no-filtration group (a mean of € 0.71/patient). In terms of satisfaction with the perioperative management of their short peripheral venous cannulation, 110 (82%) and 103 (76.9%) patients, respectively, for in-line filtration and control group, completed this survey. Within in-line filtration group, 97.3% of patients were satisfied/strongly satisfied; if compared with previous experiences on short peripheral venous cannulation, 11% of them recognised in-line filtration as a relevant causative factor in determining their satisfaction. Among patients within the control group, 93.2% were satisfied/strongly satisfied, although up to 30% of them had experienced postoperative phlebitis. At the qualitative interview, they recognised no difference than previous experiences on short peripheral venous cannulation, and mentioned postoperative phlebitis as a common event that ‘normally occurs’ during a hospital stay. Conclusion: In-line filtration is cost-effective in preventing postoperative phlebitis, and it seems to contribute to increasing patient satisfaction and reducing short peripheral venous cannulation–related discomfort

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Endotoxin removal by end-line filters

Cited by 15 publications

References 7 publications

Surface endotoxin contamination and hemocompatibility evaluation of materials

Surface endotoxin contamination and hemocompatibility evaluation of materials

Polymer Membranes in Medicine and Pharmaceutics

In-line filtration reduced phlebitis associated with peripheral venous cannulation: Focus on cost-effectiveness and patients’ perspectives

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