2012
DOI: 10.1111/hdi.12007
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Endotoxins and inflammation in hemodialysis patients

Abstract: Long-term endotoxin challenge may promote frequent complications in dialysis patients, namely malnutrition, chronic inflammation, and atherosclerosis, which are recognized as the so-called MIA syndrome. Circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) levels may be used to determine the stage of atherosclerosis. This study aimed to assess endotoxin level in hemodialysis (HD) patients and its role in inducing inflammation. The study was conducted on 50 HD patients, chosen from four dialysis cente… Show more

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Cited by 17 publications
(16 citation statements)
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“…A positive association was found between EAT thickness and the presence of significant coronary stenosis (luminal narrowing -50%) and with the number of coronary arteries with significant stenosis. In contrast, a study by Chaowalit et al (15) in 139 patients who were referred for conventional coronary angiography did not show a significant correlation between EAT thickness and number of atherosclerotic coronary segments.…”
Section: Discussionmentioning
confidence: 72%
“…A positive association was found between EAT thickness and the presence of significant coronary stenosis (luminal narrowing -50%) and with the number of coronary arteries with significant stenosis. In contrast, a study by Chaowalit et al (15) in 139 patients who were referred for conventional coronary angiography did not show a significant correlation between EAT thickness and number of atherosclerotic coronary segments.…”
Section: Discussionmentioning
confidence: 72%
“…In summary, endotoxemia may be a clinically significant problem in patients with ESKD29 30 42 contributing to chronic inflammation but its measurement is with LAL assays has limitations that need to be recognised. Our study suggests that with appropriate preanalytical handling and treatment of plasma samples, the kinetic turbidimetric LAL assay is a valid tool for the detection of endotoxemia in advanced uraemia though the accuracy and precision is more limited below 0.05 EU/mL.…”
Section: Discussionmentioning
confidence: 99%
“…The pathophysiology to explain this is unknown; however, there was a non‐statistically significant trend in allograft biopsies to show increased ATN in the DGF‐HD group (Table ). As HD has been associate with both endovascular inflammation and hemodynamic changes precipitated by the hemodialysis procedure, it is plausible that rapid fluid shifts or inflammation associated with HD in allograft recipients with DGF aggravates or precipitates ATN, whereas the more gradual solute and fluid removal of PD is relatively protective to the allograft. However, there were too few allograft biopsies to confirm this suspicion.…”
Section: Discussionmentioning
confidence: 99%