Ventilator-associated pneumonia (VAP) is a complication of mechanical ventilation and is defi ned as the occurrence of pneumonia in patients undergoing mechanical ventilation for at least 48 hours. Clinical suspicion of VAP arises when new infi ltrates are present on chest x-ray, and at least one of the following is present: Fever, leukocytosis, or purulent tracheo-bronchial secretions.Th e incidence of VAP reported in the literature ranges from 15 to 20% [1]. However, the real incidence of VAP is diffi cult to assess, given the extreme variability of the diagnostic criteria for pneumonia, which often rely on broncho scopic procedures. Th e specifi c mortality attribu table to VAP is also debated. Th e reported VAPassociated mortality ranges from 20 to 70%. Patients with VAP are often critically ill, and survival may be aff ected both by underlying conditions and the new-onset VAP. A recent study demonstrated a relatively limited attributable intensive care unit (ICU)-mortality of VAP, about 1-1.5%, when adjusting for severity of co-existing diseases [2]. In the last few years, various strategies have been investigated in order to reduce the incidence of VAP. Reducing the duration of intubation, oral and endotracheal tube (ETT) care, positioning, and ETT modifi cations are aspects that may have a role in the prevention of VAP. Many of these strategies have been incorporated into 'VAP bundles' , a set of treatments implemented simultaneously to reduce VAP incidence. Recent studies suggest that the use of bundle treatments can result in substantial reductions in rates of VAP [3].In this chapter, we will present some novel VAP prevention strategies, explaining the possible mechanisms by which they may be clinically benefi cial in reducing the incidence of VAP. A summary of these novel strategies is given in Table 1.
Reduce duration of intubationTh e risk of developing VAP increases with prolonged intu bation, and reintubation is a known risk factor [4]. Th is fact suggests that the presence of the ETT, although necessary for the survival of the patient, interferes with the normal physiological mechanisms that maintain the airways free of bacterial contamination. When the ETT is in place, the cough refl ex is impaired and normal mucociliary fl ow is blocked by the infl ated cuff . Th e ETT itself allows bacteria to drain into the trachea and distal airways leading to pneumonia. Intubated patients may be more prone to develop VAP as compared to tracheostomized patients because the ETT keeps the trachea and the oropharynx in communication, acting as a bridge for bacteria to move toward the dependent airways. Aspiration of pathogens from the oropharynx in patients with subglottic dysfunction may occur both during extubation and reintubation. Th e rate of reintubation can be reduced by a variety of measures, including avoiding accidental removal of the ETT, improving planned extubations with weaning protocols designed to improve extubation success, and use of non-invasive ventilation (NIV).On the basis of the observatio...