Endotracheal Myoepithelioma

Chand, Mastian; Mann, Jack; Sabayev, Vladimir; Luo, Jiali; Cohen, Perry; Travis, William D.; Lee, Paul C.; Paul, Subroto

doi:10.1378/chest.10-2976

Cited by 12 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because some myoepitheliomas have been shown to be malignant (6,7), the use of the term "benign myoepithelioma" is recommended to prevent confusion between benign and malignant myoepithelial lesions (2,4,5). To the best of our knowledge, there have been only four reported cases of benign myoepithelioma located in the peripheral lungs (5,(8)(9)(10) and two cases in the bronchus (2, 11).…”

Section: Discussionmentioning

confidence: 99%

“…Although the tracheobronchial submucosal glands are considered to be counterparts of the salivary glands (3), myoepithelioma of the respiratory system is extremely rare, and only two cases of tracheal myoepithelioma have been reported (4). We herein report a case of intrathoracic tracheal myoepithelioma that was followed as bronchial asthma for 1.5 years.…”

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Benign Myoepithelioma in the Intrathoracic Trachea

et al. 2014

View full text Add to dashboard Cite

A 67-year-old woman who was followed as a patient with bronchial asthma for 1.5 years visited our hospital with progressive dyspnea. Although the chest radiography findings were normal, a chest computed tomography scan revealed a mass obliterating the intrathoracic tracheal lumen. The patient's symptoms disappeared immediately after tumor excision, and no recurrence was observed during a 1.5-year follow-up period. Microscopically, the tumor was composed of densely packed polygonal-, oval-and spindle-shaped cells that were positive for pan-cytokeratin, α-smooth muscle actin and p63. These pathological findings confirmed the diagnosis of benign myoepithelioma. Chest physicians should recognize that benign myoepithelioma can develop in the trachea, although it is very rare.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

Benign Myoepithelioma in the Intrathoracic Trachea

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Five have been published previously, however clinical follow-up was not provided and clinicopathologic correlations were not investigated (Table 1) 4,8,10,22 . The tumor location, gross anatomic features, clinical history, and clinical outcome were obtained from review of consult letters, pathology reports, clinical notes, and through conversations with pathologists and/or clinicians from the submitting institutions.…”

Section: Methodsmentioning

confidence: 99%

“… * Previously reported in 4 ; • Previously reported in 4,22 ; † Previously reported in 8 ; ‡ Previously reported in 10 AWD = alive with disease; NED = no evidence of disease; CT/RT = chemotherapy and radiotherapy …”

Section: Figurementioning

confidence: 99%

Thoracic Myoepithelial Tumors

Leduc

Zhang

Öz

et al. 2016

American Journal of Surgical Pathology

Self Cite

View full text Add to dashboard Cite

Thoracic myoepithelial tumors (MTs) are a rare group of tumors showing predominant or exclusive myoepithelial differentiation. They are poorly characterized from both a morphologic and genetic standpoint, in particular features that separate benign from malignant behavior. We examined the histologic and immunohistochemical features of 8 primary thoracic MTs and performed fluorescence in situ hybridization for EWSR1, FUS, PLAG1, and HMGA2, as well as several partner genes. Half (4/8) of the MTs occurred in large airways and 3 had infiltrative borders. All cases showed immunoreactivity for epithelial markers, in conjunction with S-100 protein or myogenic markers. MTs showed morphologic characteristics analogous to MTs at other sites, with no tumors having ductal differentiation. Necrosis and/or lymphovascular invasion was present in 5 cases, with mitotic activity ranging from 0–6 mitoses/2 mm2 (mean 1). Metastases occurred in 2 cases, and no patients died of disease. Gene rearrangements were identified in half of the cases, with EWSR1-PBX1, EWSR1-ZNF444, and FUS-KLF17 fusions identified in one case each, and one case having EWSR1 rearrangement with no partner identified. No cases were found to have HMGA2 or PLAG1 abnormalities. Compared to fusion negative tumors, fusion positive tumors tended to occur in patients who were younger (50 vs 58 yrs), female (1:3 vs 3:1 male:female ratio), and demonstrated predominantly spindle and clear cell morphology. Using a combined dataset of our case series with 16 cases from the literature, poor prognosis was significantly correlated with metastases (p=0.003), necrosis (p=0.027), and ≥ 5 mitoses per 2mm2/10 HPF (p=0.005). In summary, we identify a subset of thoracic MTs harboring rearrangements in EWSR1 or FUS, and our data suggests that necrosis and increased mitotic activity correlate with aggressive clinical behavior.

show abstract

“…Myoepithelial cell neoplasms represent a histologically broad spectrum and well defi ned tumor group, especially for salivary glands [1]. Extra-salivary gland representatives of these neoplasms are rare and include bone, respiratory tract, breast and retroperitoneum [1][2][3][4]. CM and soft tissue myepitheliomas have relatively newly been defi ned [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous syncytial myoepithelioma: A potential pitfall in the differential diagnosis of superfi cial dermal tumors

Çomut¹,

Demirkan²

2019

J Surg Surgical Res

View full text Add to dashboard Cite

In the spectrum of myoepithelial tumors of the skin, cutaneous myoepithelioma is composed solely of myoepithelial cells. Cutaneous syncytial myoepithelioma as a rare histological variant of cutaneous myoepithelioma has been fi rst described in the last decade. This tumor is benign and rarely shows recurrence when incompletely resected. In addition to its distinctive common histological and immunohistochemical features, cutaneous syncytial myoepithelioma shares the same changes for most cases in molecular testing (EWS RNA binding protein 1 gene rearrangement). The differential diagnosis of other superfi cial dermal tumors is one of the major diffi culties in the diagnosis of this tumor. In the current study, we present our fi ndings of a 56 year-old woman who was diagnosed as cutaneous syncytial myoepithelioma.

show abstract

Endotracheal Myoepithelioma

Cited by 12 publications

References 10 publications

Benign Myoepithelioma in the Intrathoracic Trachea

Benign Myoepithelioma in the Intrathoracic Trachea

Thoracic Myoepithelial Tumors

Cutaneous syncytial myoepithelioma: A potential pitfall in the differential diagnosis of superfi cial dermal tumors

Contact Info

Product

Resources

About