Endotypes of pollen‐food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification

Mastrorilli, Carla; Tripodi, Salvatore; Caffarelli, Carlo; Perna, Serena; Rienzo-Businco, Andrea Di; Sfika, Ifigenia; Asero, Riccardo; Dondi, Arianna; Bianchi, Annamaria; Dascola, Carlotta Povesi; Ricci, Giampaolo; Cipriani, Francesca; Maiello, Nunzia; Giudice, Michele Miraglia Del; Frediani, T.; Frediani, Simone; Macrì, Francesco; Pistoletti, Chiara; Iacono, Iride Dello; Patria, Maria Francesca; Varin, Elena; Peroni, Diego; Comberiati, Pasquale; Chini, L; Moschese, Viviana; Lucarelli, Sonia; Bernardini, Roberto; Pingitore, Giuseppe; Pelosi, U; Olcese, Roberta; Moretti, Matteo; Cirisano, Anastasia; Faggian, Diego; Travaglini, Alessandro; Plebani, Mario; Verga, Maria Carmen; Calvani, Mauro; Giordani, Paolo; Matricardi, Paolo Maria

doi:10.1111/all.12888

Cited by 72 publications

(80 citation statements)

References 35 publications

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“…The significant association between asthma and PFAS has also been reported in previous studies. [7][8][9] Our data, showed no differences in age, gender, duration of the pollen-related primary allergic disease, between the patients with and without PFAS. Contrary to this result, two previous studies reported longer durations of allergic rhinitis in patients with PFAS.…”

Section: Risk Factors Of Pfasmentioning

confidence: 42%

“…In the recent multicenter study of Mastrorilli et al, which is performed in Italy, in another Mediterranean country, kiwi fruit was also the food that is most commonly triggering PFAS. 8 Another large study performed in Italy, also reported kiwi fruit to be the most frequently reported plant-derived food to be a cause of allergic reactions. 12 Allergic reactions to kiwi have been reported in association with birch and grass pollen allergies.…”

Section: Discussionmentioning

confidence: 98%

“…Contrary to this result, two previous studies reported longer durations of allergic rhinitis in patients with PFAS. 8,9 However, another large study found no significant difference in the duration of birch pollen allergy in patients with and without PFAS. 10 Because of the regional differences in pollen distribution, the prevalence and implicated foods vary between different geographical regions.…”

Section: Risk Factors Of Pfasmentioning

confidence: 99%

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Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens

Özdemir

Özgüςlü

2017

Asian Pac J Allergy Immunol

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Section: Risk Factors Of Pfasmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 98%

Section: Risk Factors Of Pfasmentioning

confidence: 99%

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Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens

Özdemir

Özgüςlü

2017

Asian Pac J Allergy Immunol

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“…Multiple sensitizations were common: 14 were monosensitized, 37 were sensitized to 2–3 allergens and 49 % to more than 3 allergens. This point out that molecular diagnosis would be often necessary to distinguish between polysensitized children who are sensitized to genuine allergens and those sensitized to cross-reactive allergens [11]. The average number of symptoms in the atopic group was 3.3 vs 2.8 in the non-atopic group.…”

Section: Reviewmentioning

confidence: 99%

Progress in pediatrics in 2015: choices in allergy, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, nephrology, neurology, nutrition, oncology and pulmonology

et al. 2016

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This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature. Epidemiological studies have evidenced the high incidence of Graves’ disease and Hashimoto’s thyroiditis in patients with Down syndrome. Documentation of novel risk factors for celiac disease are of use to develop strategies for prevention in the population at-risk. Diagnostic criteria for non-celiac gluten sensitivity have been reported. Negative effect on nervous system development of the supernumerary X chromosome in Klinefelter syndrome has emerged. Improvements have been made in understanding rare diseases such as Rubinstein-Taybi syndrome. Eltrombopag is an effective therapy for immune trombocytopenia. Children with sickle-cell anemia are at risk for nocturnal enuresis. Invasive diseases caused by Streptococcus pyogenes are still common despite of vaccination. No difference in frequency of antibiotic prescriptions for acute otitis media between before the publication of the national guideline and after has been found. The importance of timing of iron administration in low birth weight infants, the effect of probiotics for preventing necrotising enterocolitis and perspectives for managing jaundice and cholestasis in neonates have been highlighted. New strategies have been developed to reduce the risk for relapse in nephrotic syndrome including prednisolone during upper respiratory infection. Insights into the pathophysiology of cerebral palsy, arterial ischemic stroke and acute encephalitis may drive advances in treatment. Recommendations on breastfeeding and complementary feeding have been updated. Novel treatments for rhabdomyosarcoma should be considered for paediatric patients. Control of risk factors for bronchiolitis and administration of pavilizumab for preventing respiratory syncytial virus infection may reduce hospitalization. Identification of risk factors for hospitalization in children with wheezing can improve the management of this disease. Deletions or mutations in genes encoding proteins for surfactant function may cause diffuse lung disease.

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“…Whether Gal1 can alleviate oral allergy has not been investigated. Since some foods can be the offending antigens of oral allergy [10], we hypothesize that oral allergy and intestinal allergy may concomitantly occur, a phenomenon may be designated the “oral-intestinal allergy syndrome (OIAS)”. To test this, we sensitized mice by application of antigens to the mouse buccal mucosa.…”

Section: Introductionmentioning

confidence: 99%

Galectin-1 inhibits oral-intestinal allergy syndrome

Xie

Yang

et al. 2017

Oncotarget

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Background and aimsThe pathogenesis of oral-intestinal allergy syndrome (OIAS) has not been well understood. Published data indicate that galectin (Gal) 1 has immune regulatory functions. This study tests a hypothesis that Gal1 inhibits oral-intestinal allergy syndrome.MethodsMice were sensitized to peanut extracts (PE) via the buccal mucosa with or without using Gal1 together.ResultsUpon re-exposure to specific antigen, the OIAS mice showed the systemic allergic response, the oral allergic reactions, and intestinal allergic inflammation, including increases in serum histamine, drop of the core temperature, higher levels of PE-specific IgE and interleukin (IL)-4. Increases in mast cell and eosinophil in the oral mucosa and intestinal mucosa were also observed. The OIAS was inhibited by co-administration with Gal1 via a mechanism of suppressing micro RNA (miR)-98 and reversing the expression of IL-10 in CD14+ cells in the intestine.ConclusionsThe OIAS can be induced by applying specific antigens to the oral mucosa, which can be inhibited by co-administration with Gal1.

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Endotypes of pollen‐food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification

Cited by 72 publications

References 35 publications

Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens

Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens

Progress in pediatrics in 2015: choices in allergy, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, nephrology, neurology, nutrition, oncology and pulmonology

Galectin-1 inhibits oral-intestinal allergy syndrome

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