Endovascular beta irradiation for prevention of restenosis using solution radioisotopes

Knapp, F. F.; Guhlke, Stefan; Beets, A.L.; Lin, Wan‐Yu; Stabin, Michael G.; Amols, Howard; Weinberger, Judah

doi:10.1016/s1522-1865(98)00009-2

Cited by 28 publications

(15 citation statements)

References 15 publications

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“…Bei flüssigen Beta-Strahlern besteht die Gefahr der akzidentellen Inkorporation und damit Patientenkontamination durch Ballonruptur. Das flüssige Rhenium-188 wird nach akzidenteller Inkorporation vorwiegend von der Schilddrüse und dem Gastrointestinaltrakt aufgenommen [27] Stentneuimplantation unter alleiniger Gabe von 75 mg Clopidogrel über 1 Monat plus 100 mg ASS bei dieser Indikation ebenfalls eine verlängerte Clopidogrel-Medikation nahe, wenngleich hierzu für periphere Arterien keine Studien existieren und sowohl in der Vienna-1- [40] wie in der Vienna-2-Studie [34] nach alleiniger PTA lediglich 100 mg ASS mit gutem Erfolg verwandt wurden.…”

Section: Beta-oder Gamma-strahler?unclassified

Endovaskuläre Brachytherapie in der Restenoseprophylaxe nach Angioplastie und Stentimplantation: Eine Übersicht

Wohlgemuth¹,

Bohndorf²

2003

Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr

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Endovascular radiotherapy is the first effective prophylaxis of restenosis after percutaneous transluminal angioplasty (PTA) and stenting. The FDA recently approved two devices for the delivery of intracoronary radiation following coronary artery stenting. Published multicenter, double-blind, randomized trials of intracoronary radiation therapy report good results for preventing in-stent restenosis, while the data for the peripheral circulation are still inconclusive. Beta-emitters are easier applicable and probably also safer, whereas gamma-emitters have been more extensively evaluated clinically so far. Primary indication for endovascular brachytherapy are patients at high risk for restenosis, such as previous restenoses, in-stent hyperplasia, long stented segment, long PTA lesion, narrow residual vascular lumen and diabetes. Data from coronary circulation suggest a safety margin of at least 4 to 10 mm at both ends of the angioplastic segment to avoid edge restenosis. To prevent late thrombosis of the treated coronary segment, antiplatelet therapy with clopidogrel and aspirin are recommended for at least 6 months after PTA and for 12 months after a newly implanted stent. An established medication regimen after radiotherapy of peripheral arteries is still lacking.

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Section: Beta-oder Gamma-strahler?unclassified

Endovaskuläre Brachytherapie in der Restenoseprophylaxe nach Angioplastie und Stentimplantation: Eine Übersicht

Wohlgemuth¹,

Bohndorf²

2003

Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr

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“…Alternatively, a faster clearance of 188 ReO 4 than 125 I from blood circulation may also contribute to a shorter retention time of 188 ReO 4 in NIS-transduced gliomas. 39,40 The slower clearance of 125 I from blood circulation is anticipated by the large iodide pool in vivo that is contributed by the thyroid gland reservoir and entero-recirculation. 41 While 188 Re has been investigated for various clinical applications, such as endovascular brachytherapy or labeling various compounds to treat cancer and to palliate bone pain, 42,43 this is the first report to examine the therapeutic effectiveness of 188 ReO 4 for NIS-expressing tumors.…”

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Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy

et al. 2004

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The sodium iodide symporter (NIS) mediates iodide uptake into thyrocytes and is the molecular basis of thyroid radioiodine therapy. We previously have shown that NIS gene transfer into the F98 rat gliomas facilitated tumor imaging and increased survival by radioiodine. In this study, we show that: (1) the therapeutic effectiveness of 131 I in prolonging the survival time of rats bearing F98/hNIS gliomas is dose-and treatment-time-dependent; (2) the number of remaining NISexpressing tumor cells decreased greatly in RG2/hNIS gliomas post 131 I treatment and was inversely related to survival time; (3) 8 mCi each of 125 I/ 131 I is as effective as 16 mCi 131 I alone, despite a smaller tumor absorbed dose; (4) 188 ReO 4 , a potent b À emitter, is more efficient than 131 I to enhance the survival of rats bearing F98/hNIS gliomas. These studies demonstrate the importance of radiopharmaceutical selection, dose, and timing of treatment to optimize the therapeutic effectiveness of NIS-targeted radionuclide therapy following gene transfer into gliomas.

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“…Knapp et al, em 1999 [60] , utilizaram o sistema de concentração com trocadores catiônico/aniônico em série com o uso de solução de NaCl 0,9 % para a [63] , pesquisaram um sistema automatizado e controlado por microprocessadores que otimizam a concentração e a marcação, usando 3 cartuchos catiônicos (IC-Ag Alltech) dispostos em paralelo ou em série conectados com um cartucho aniônico (QMA -Waters), diminuindo a exposição à radiação dos operadores (automação) e os problemas de limite de volume de eluição (3 cartuchos catiônicos dispostos em paralelo).…”

Section: Coluna De Gerador De Gelunclassified

“…O detector de germânio tem a calibração de energia-γ feita por meio de fontes calibradas de 60 TABELA 7 -Limites de impurezas radionuclídicas do 99 Mo a partir de 98 Mo(n,γ) 99 Mo.…”

Section: Detector De Germânio Hiperpurounclassified

Estudos de técnicas de concentração da atividade de 99mTc eluído de geradores de 99Mo/99mTc tipo gel

Suzuki¹

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On average 80% of the radiopharmaceuticals used in Nuclear Medicine are labeled with 99m Tc due to its physical properties and easy attainment through of 99 Mo/ 99m Tc generators. The Directory of Radiopharmacy (DIRF) of IPEN-CNEN/SP developed a gel type chromatographic generator of MoZr with 99 Mo produced by 98 Mo(n,γ) 99 Mo reaction that occurs at the IEA-R1 Nuclear Reactor. The gel is composed of zirconium molibdate with elution volume of 12 mL with an activity of 11100 MBq (300 mCi) producing a radioactive concentration of 925 MBq (25 mCi)/mL. The fission generator gives a higher radioactive concentration around 1850 MBq (50 mCi)/mL. The aim of this work is to study a system of post-elution concentration of 99m Tc for the attainment of a high enough radioactive concentration to meet the demands of the market, with a proved quality. Two types of systems of post-elution concentration were developed: the single and the tandem. The most appropriate system for the gel generator of 99 Mo/ 99m Tc, being at the same time sterile and vacuum automated, was the tandem system using Dionex 2.5 cc/QMA cartridges. The gel generator is eluted with 10 mL of solution of 0.1% NaCl and the pertechnetate anion is retained in the QMA cartridge and further eluted with 4 mL of saline. The process takes no more than 30 minutes. The elution efficiency of the system of concentration was 90 %. At the beginning of 2009 a global crisis in the supply of 99 Mo took place making it necessary the development of alternative technologies for the production of 99 Mo/ 99m Tc generators using fission produced 99 Mo and the development of an appropriate method to extend the useful life of this generator. The results of this study showed that the same system developed for the post-concentration of the gel generator can be employed for the fission generator, using the tandem system, giving a concentration factor of 3 for the elution of 99m Tc. LISTA DE FIGURAS FIGURA 1 Curva de decaimento e crescimento do gerador de 99 Mo/ 99m Tc

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Endovascular beta irradiation for prevention of restenosis using solution radioisotopes

Cited by 28 publications

References 15 publications

Endovaskuläre Brachytherapie in der Restenoseprophylaxe nach Angioplastie und Stentimplantation: Eine Übersicht

Endovaskuläre Brachytherapie in der Restenoseprophylaxe nach Angioplastie und Stentimplantation: Eine Übersicht

Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy

Estudos de técnicas de concentração da atividade de 99mTc eluído de geradores de 99Mo/99mTc tipo gel

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