Endovascular papillary angioendothelioma (Dabska tumor): underrecognized malignant tumor in childhood

Neves, Rogério I.; Stevenson, Julia; Hancey, M. Jason; Vangelisti, Garrett; Miraliakbari, Reza; Mackay, Donald R.; Clarke, Loren E.

doi:10.1016/j.jpedsurg.2010.09.046

Cited by 34 publications

(27 citation statements)

References 10 publications

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“…In addition, a recent publication reports a case of PILA in a 12-year-old boy. 7 The localization of the tumor was comparable with that in our case. The lesion measured 5 mm in diameter and was longstanding before growing gradually in size to 10 mm and starting to bleed.…”

Section: Discussionsupporting

confidence: 87%

Retiform Hemangioendothelioma Developed on the Site of an Earlier Cystic Lymphangioma in a Six-Year-Old Girl

Albertini

Brousse

Bodemer

et al. 2011

The American Journal of Dermatopathology

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Retiform hemangioendothelioma (RH) is a rare low-grade malignancy angiosarcoma, with a high rate of local recurrence and a low metastatic risk. A 6 year-old girl with a large cervical cystic lymphangioma diagnosed by ultrasound and Doppler ultrasound, which showed a large multiloculated anechoic cyst with no flow. The lymphangioma was treated with injections of Picibanil (OK-432). The tumor regressed, but after a year, she developed a poorly limited infiltrated plaque spreading out regularly over her chest, back, and shoulder. The biopsy showed a poorly limited dermal and subcutaneous vascular proliferation composed of elongated arborising vessels lined with ovoid endothelial cells in a hobnail pattern. In addition, the deep part of the lesion showed typical features of a papillary intralymphatic angioendothelioma pattern (PILA) or Dabska tumor. The endothelial cells strongly expressed podoplanin (D2-40). A diagnosis of RH with focal areas of PILA was reached. The girl died 8 months after surgery of hypovolemic shock in a context of diffuse lymphangiomatosis with pulmonary localization. To our knowledge, RH has hardly ever been described in children. This entity exhibits a continuum with the PILA, sharing not only morphological and immunohistochemical similarities but also its ability to develop in a context of a vascular anomaly, particularly a lymphangioma. The role of Picibanil in the development of this tumor can be discussed.

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Section: Discussionsupporting

confidence: 87%

Retiform Hemangioendothelioma Developed on the Site of an Earlier Cystic Lymphangioma in a Six-Year-Old Girl

Albertini

Brousse

Bodemer

et al. 2011

The American Journal of Dermatopathology

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“…The age of the patients ranged from few months to 83 years, and there was no sex predilection [6]. Besides skin and subcutaneous tissue, the tumor has been described in other deeper locations like the spleen [5], soft tissues [7, 8], bone [4], and tongue [3]. The clinical appearance is variable.…”

Section: Discussionmentioning

confidence: 99%

Strong ERG Positivity in Papillary Intralymphatic Angioendothelioma of the Testis of a 24-Year-Old Male: A Case Report

Schultheis

Sandmann

Steurer

2013

Case Reports in Pathology

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Papillary intralymphatic angioendothelioma is a rare, low-grade neoplasm of lymphatic channels that usually presents intradermally or subcutaneously. We report the case of a 24-year-old male presenting with an isolated intratesticular palpable mass and symptoms of testicular pain. Preoperative ultrasound examination showed an irregular, heterogeneous mass. Subsequent surgery and pathologic assessment revealed a papillary intralymphatic angioendothelioma (PILA), formerly known as Dabska tumor within the lymphatic spaces.

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“…Predilection sites include skin and superficial soft tissue of head and neck, trunk or extremities, but PILA was also reported to arise in tongue, spleen, bone, muscle and testis. [1][2][3][4][5][6][7] Typically occurring in children and young adults, PILA may also affect the elderly. 8 Referring to the approximately 40 cases described to date, lesion size ranges from one to 40 cm in diameter, with 'typical' lesions measuring about 2-3 cm.…”

Section: Editormentioning

confidence: 99%

Papillary intralymphatic angioendothelioma (PILA), also referred to as Dabska tumour, in an 83‐year‐old woman

Kügler

Koelblinger

Zelger

et al. 2015

Acad Dermatol Venereol

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Endovascular papillary angioendothelioma (Dabska tumor): underrecognized malignant tumor in childhood

Cited by 34 publications

References 10 publications

Retiform Hemangioendothelioma Developed on the Site of an Earlier Cystic Lymphangioma in a Six-Year-Old Girl

Retiform Hemangioendothelioma Developed on the Site of an Earlier Cystic Lymphangioma in a Six-Year-Old Girl

Strong ERG Positivity in Papillary Intralymphatic Angioendothelioma of the Testis of a 24-Year-Old Male: A Case Report

Papillary intralymphatic angioendothelioma (PILA), also referred to as Dabska tumour, in an 83‐year‐old woman

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