Endovascular Repair of Abdominal Aortic Aneurysm

Cooper, Adam S.

doi:10.4037/ccn2014184

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…Clinically, despite the rapid development of medical imaging technology and surgical interventions, the clinical treatment of AAA is currently limited to endovascular techniques or open surgery for aneurysms larger than 5.5 cm. Pharmacological treatments are lacking for the condition, and effective nonsurgical treatments to modify the natural history of AAA progression have not been validated [3].…”

Section: Introductionmentioning

confidence: 99%

IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

Chai

Tao

et al. 2020

Oxidative Medicine and Cellular Longevity

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Abdominal aortic aneurysm (AAA) is a vascular disorder that is considered a chronic inflammatory disease. However, the precise molecular mechanisms involved in AAA have not been fully elucidated. Recently, significant progress has been made in understanding the function and mechanism of action of inhibitor of kappa B kinase epsilon (IKKε) in inflammatory and metabolic diseases. The angiotensin II- (Ang II-) induced or pharmacological inhibitors were established to test the effects of IKKε on AAA in vivo. After mice were continuously stimulated with Ang II for 28 days, morphologically, we found that knockout of IKKε reduced AAA formation and drastically reduced maximal diameter and severity. We also observed a decrease in elastin degradation and medial destruction, which were independent of systolic blood pressure or plasma cholesterol concentrations. Western blot analyses and immunohistochemical staining were carried out to measure IKKε expression in AAA tissues and cell lines. AAA phenotype of mice was measured by ultrasound and biochemical indexes. In zymography, immunohistology staining, immunofluorescence staining, and reactive oxygen species (ROS) analysis, TUNEL assay was used to examine the effects of IKKε on AAA progression in AAA mice. IKKε deficiency significantly inhibited inflammatory macrophage infiltration, matrix metalloproteinase (MMP) activity, ROS production, and vascular smooth muscle cell (VSMC) apoptosis. We used primary mouse aortic VSMC isolated from apolipoprotein E (Apoe) −/− and Apoe−/−IKKε−/− mice. Mechanistically, IKKε deficiency blunted the activation of the ERK1/2 pathway. The IKKε inhibitor, amlexanox, has the same impact in AAA. Our results demonstrate a critical role of IKKε in AAA formation induced by Ang II in Apoe−/− mice. Targeting IKKε may constitute a novel therapeutic strategy to prevent AAA progression.

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Section: Introductionmentioning

confidence: 99%

IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

Chai

Tao

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…2 The most serious concern of this aortic disease among the aged population is the reliance on surgical repair or endovascular aneurysm repair for treatment. 3 Hence, it is important to understand the cellular and molecular mechanisms of AAA pathogenesis to aid the development of non-invasive therapies.…”

Section: Introductionmentioning

confidence: 99%

Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms

Zhou

Lindholt

et al. 2015

Cardiovascular Research

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A Finite Element-Based Analysis of a Hemodynamics Efficient Flow Stent Suitable for Different Abdominal Aneurysm Shapes

Nada

Fakhr

El-Wakad

et al. 2022

Journal of Biomechanical Engineering

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This research aimed to examine the impact of a proposed flow stent (PFS) on different abdominal artery shapes. For that purpose, a finite element-based model using the computational fluid dynamics (CFD) method is developed. The effect of PFS intervention on the hemodynamic efficiency is estimated by all of the significant criteria used for the evaluation of aneurysm occlusion and possible rupture; the flow velocity, pressure, wall shear stress (WSS), and WSS-related indices. Results showed that PFS intervention preserves the effects of high flow rate and decreases irregular flow recirculation in the sac of the aneurysm. The flow velocity decreases inside the aneurysm sac in the range of 55% to 80%. The time-averaged wall shear stress (TAWSS) was reduced from 42% to 53% by FPS deployment. The simulation results implies that PFS could heal an aneurysm efficiently with a mechanism that causes the development of thrombus and ultimately leads to aneurysm resorption.

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Endovascular Repair of Abdominal Aortic Aneurysm

Cited by 3 publications

References 1 publication

IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms

A Finite Element-Based Analysis of a Hemodynamics Efficient Flow Stent Suitable for Different Abdominal Aneurysm Shapes

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