Endovascular repair versus open repair for inflammatory abdominal aortic aneurysms

Capoccia, Laura; Riambau, Vicente

doi:10.1002/14651858.cd010313

Cited by 1 publication

(1 citation statement)

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“…Hence, diagnostic criteria involving both histology and blood sampling have been established to define inflammatory and IgG4-positive AAA. Uncertainty remains about the true prevalence of both entities and the ideal treatment strategy [15,17].…”

Section: Of 12mentioning

confidence: 99%

The Incidence of IgG4-Related and Inflammatory Abdominal Aortic Aneurysm Is Rare in a 101 Patient Cohort

Nackenhorst,

Kapalla,

Weidle

et al. 2023

JCM

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Abdominal aortic aneurysms (AAA) are the most frequent aortic dilation, with considerable morbidity and mortality. Inflammatory (infl) and IgG4-positive AAAs represent specific subtypes of unclear incidence and clinical significance. Here, histologic and serologic analyses with retrospective clinical data acquisition are investigated via detailed histology, including morphologic (HE, EvG: inflammatory subtype, angiogenesis, and fibrosis) and immunhistochemic analyses (IgG and IgG4). In addition, complement factors C3/C4 and immunoglobulins IgG, IgG2, IgG4 and IgE were measured in serum samples and clinical data uses patients’ metrics, as well as through semi-automated morphometric analysis (diameter, volume, angulation and vessel tortuosity). A total of 101 eligible patients showed five (5%) IgG4 positive (all scored 1) and seven (7%) inflammatory AAAs. An increased degree of inflammation was seen in IgG4 positive and inflAAA, respectively. However, serologic analysis revealed no increased levels of IgG or IgG4. The operative procedure time was not different for those cases and the short-term clinical outcomes were equal for the entire AAA cohort. Overall, the incidence of inflammatory and IgG4-positive AAA samples seems very low based on histologic and serum analyses. Both entities must be considered distinct disease phenotypes. Short-term operative outcomes were not different for both sub-cohorts.

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Section: Of 12mentioning

confidence: 99%