Endovascular revascularisation versus conservative management for intermittent claudication

Fakhry, Farzin; Fokkenrood, H.J.P.; Spronk, Sandra; Teijink, Joep A.W.; Rouwet, Ellen V.; Hunink, M. G. Myriam

doi:10.1002/14651858.cd010512.pub2

Cited by 54 publications

(41 citation statements)

References 59 publications

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“…Endovascular or open surgery may be considered for patients with IC who have severely disabling symptoms and does not respond to SET 7, 43,44 . A Cochrane review from 2018, comparing endovascular revascularization and conservative treatment for IC, concluded with a moderate effect on MWD and a large effect on PWD after 6-12 months, but no clear differences were shown between the groups after long-term follow-up 45 . Different outcome measures and study design does not allow for direct comparisons to the findings in the present study.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

A randomized controlled trial of treatment with intermittent negative pressure for intermittent claudication

Hoel

Pettersen

Høiseth

et al. 2021

Journal of Vascular Surgery

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

A randomized controlled trial of treatment with intermittent negative pressure for intermittent claudication

Hoel

Pettersen

Høiseth

et al. 2021

Journal of Vascular Surgery

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“…It also produces a substantial economic burden on society due to reduced working ability, hospitalisation, and associated personal and social consequences for the individual patient [12,13]. A recent Cochrane review [14] concluded that for patients with IC exercise is important regardless of whether treatment is revascularisation or overall conservative management. Supervised exercise training (SET) programmes are effective for alleviating symptoms, increasing walking distance, reducing cardiovascular risk factors and improving quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…Supervised exercise training (SET) programmes are effective for alleviating symptoms, increasing walking distance, reducing cardiovascular risk factors and improving quality of life. Additionally, SET is relatively inexpensive and cost-efficient compared with other more invasive therapies [13][14][15][16]. Although evidence for SET is strong, studies exploring the effects of cross-sectoral rehabilitation intervention on patients treated for IC are lacking.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectoral rehabilitation intervention for patients with intermittent claudication versus usual care for patients in non-operative management - the CIPIC Rehab Study: study protocol for a randomised controlled trial

Siercke

Jørgensen

Missel

et al. 2020

Trials

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Introduction: Intermittent claudication (IC) caused by peripheral artery disease (PAD) is a common cardiovascular disease. Patients with IC have reduced walking capacity, restricted activity levels and mobility, and reduced healthrelated quality of life. The disease leads to social isolation, the risk of cardiovascular morbidity, and mortality. Nonoperative management of IC requires exercise therapy and studies show that supervised exercise training is more effective than unsupervised training, yet many patients with IC lack motivation for changes in health behaviour. No studies investigating the effects of existing cardiac rehabilitation targeted patients with IC have been published. The aim of this article is to present the rationale and design of the CIPIC Rehab Study, which examines the effect of a cross-sectoral rehabilitation programme versus usual care for patients in non-operative management for IC. Methods and analysis: A randomised clinical trial aims to investigate whether cardiac rehabilitation for patients with IC in non-operative management versus usual care is superior to treatment as usual. The trial will allocate 118 patients, with a 1:1 individual randomisation to either the intervention or control group. The primary outcome is maximal walking distance measured by the standardised treadmill walking test. The secondary outcome is pain-free walking distance measured by the standardised treadmill walking test, healthy diet measured by a fat-fish-fruit-green score, and level of physical activity measured by an activity score within official recommendations. Statistical analyses will be blinded. Several exploratory analyses will be performed. A mixed-method design is used to evaluate qualitative and quantitative findings. A qualitative and a survey-based complementary study will be undertaken to investigate patients' post-discharge experiences. A qualitative post-intervention study will explore experiences of participation in rehabilitation.

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“…The VQ6 has acceptable to good psychometric properties regarding data quality, scale assumptions, targeting, validity and reliability. Further, VQ6 seems to be easy to use and comprehend within the target population of patients with PAD(14).The Patient Activation Measure PAM-13 is a 13 item instrument for evaluating educational interventions aimed at improving patient engagement. Patient activation specifies the level of patients' engagement and may contribute to better self-management, higher engagement in treatment and greater patient satisfaction.…”

mentioning

confidence: 99%

Cross-sectoral rehabilitation intervention for patients with intermittent claudication versus usual care for patients in non-operative management - The CIPIC Rehab study: study protocol for a randomised controlled trial

Siercke

Jørgensen

Missel

et al. 2019

Preprint

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Introduction: Intermittent claudication (IC) caused by Peripheral Artery Disease (PAD) is a common cardiovascular disease. Patients with IC have reduced walking capacity, restricted activity levels and mobility, and reduced health-related quality of life. The disease leads to social isolation, the risk of cardiovascular morbidity, and mortality. Non-operative management of IC requires exercise therapy and studies show that supervised exercise training is more effective than unsupervised training, yet many patients with IC lack motivation for changes in health behavior. No studies investigating the effects of existing cardiac rehabilitation targeted patients with IC have been published. The aim of this paper is to present the rationale and design of the CIPIC Rehab Study, which examines the effect of a cross-sectoral rehabilitation programme versus usual care for patients in non-operative management for IC. Methods and analysis: A randomised clinical trial aims to investigate whether cardiac rehabilitation for patients with IC in non-operative management versus usual care is superior to treatment as usual. The trial will allocate 118 patients, 1:1 individual randomisation to either the intervention or control group. The primary outcome is maximal walking distance measured by the standardised treadmill walking test. The secondary outcome is pain-free walking distance measured by the standardised treadmill walking test, healthy diet measured by a fat-fish-fruit-green score, and level of physical activity measured by activity score within official recommendations. Statistical analyses will be blinded. Several exploratory analyses will be performed. A mixed-method design is used to evaluate qualitative and quantitative findings. A qualitative and a survey-based complementary study will be undertaken to investigate patients’ post-discharge experiences. A qualitative post-intervention study will explore experiences of participation in rehabilitation. Discussion: The study is the first to assess the effect of a cardiac rehabilitation programme designed for patients with intermittent claudication. The study will describe how to monitor and improve rehabilitations programme for patients with intermittent claudication in a real-world setting. Mixed method strategies can allow for both exploration and generalization in the same study, but the research design is a complex intervention and any effects found can not be awarded a specific component.

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Endovascular revascularisation versus conservative management for intermittent claudication

Cited by 54 publications

References 59 publications

A randomized controlled trial of treatment with intermittent negative pressure for intermittent claudication

A randomized controlled trial of treatment with intermittent negative pressure for intermittent claudication

Cross-sectoral rehabilitation intervention for patients with intermittent claudication versus usual care for patients in non-operative management - the CIPIC Rehab Study: study protocol for a randomised controlled trial

Cross-sectoral rehabilitation intervention for patients with intermittent claudication versus usual care for patients in non-operative management - The CIPIC Rehab study: study protocol for a randomised controlled trial

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