EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry

Abstract

PurposeThe Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry.ParticipantsAll centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS).Findings to dateCurrently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups.Future plansThis collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findings may likewise be hypothesis generating for future research as well as for quality improvement (on EVT). The collaboration welcomes participation of further centres willing to fulfill the commitment and the outlined requirements.

IV Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors

“…We performed a multicenter retrospective registry-based analysis within the European Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration collecting data of patients admitted for suspected acute ischemic stroke. 18,19 Fourteen centers participated in this study (eTable 1, links.lww.com/WNL/C990). Patients were included if they received treatment with IVT with or without additional endovascular treatment (EVT) or if they received EVT without previous IVT but with use of intraarterial thrombolysis (IAT) and if any intracranial tumor was diagnosed before stroke or during stroke including the time of follow-up.…”

“…We performed a multicenter retrospective registry-based analysis within the European Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration collecting data of patients admitted for suspected acute ischemic stroke. 18,19 Fourteen centers participated in this study (eTable 1, links. lww.com/WNL/C990).…”

Safety and effectiveness of IV Thrombolysis in retinal artery occlusion: A multicenter retrospective cohort study

“…The data for this study was obtained from the TRISP (ThRombolysis in Ischemic Stroke Patients) collaboration containing >10,000 prospectively collected data sets of IVT treated patients from 20 European stroke centers. 12 , 13 The locally obtained data was anonymized at the respective center, and then sent and pooled for analysis by the study coordinators in Zurich.…”

Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration

“…EVT included the possible use of a stent retriever, mechanical aspiration, balloon angioplasty, and deposition of a permanent intracranial or extracranial stent, all as a single intervention or as a combination of different techniques as outlined in the EVA-TRISP-methods publication. 12…”

“…The methods of EVA-TRISP have been described recently. 12 In brief, EVA-TRISP has evolved from the investigator-initiated, international ThRombolysis in Ischemic Stroke Patients (TRISP) collaboration, 13 which published multiple inter-…”