Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

Komiyama, Masaki; Nakajima, Hideki; Kitano, Shouhei; Sakamoto, Hiroaki; Kurimasa, Hiroko; Ozaki, Hajime

doi:10.1159/000028971

Cited by 26 publications

(15 citation statements)

References 8 publications

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“…In large tumors, TAE can be a useful bridge before surgery is attempted or until the systemic treatment becomes effective [43,101,102]. There are also multiple case reports of successful treated KMS with endovascular approaches [103][104][105][106]. As mentioned in Table 1, KMS secondary to liver hemangiomas [107] and Merkel cell cancer involving the face [108] has been successfully treated with TAE.…”

Section: Others Embolizationmentioning

confidence: 99%

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Master¹,

Kallam²,

Eo³

et al. 2017

J Blood Disord Transfus

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Kasabach-Merritt syndrome (KMS) consists of a clinical trial of capillary hemangioma, thrombocytopenia and disseminated intravascular coagulation. KMS occurs most commonly in the pediatric population, and its occurrence in adults is rare. Specific guidelines or randomized clinical trials guiding clinical management of KMS in adult patients are lacking. This manuscript provides a comprehensive review of KMS and discusses recent advances in the medical management of KMS. We also propose a systematic therapeutic approach which would serve as a guide in the management of adult patients with KMS caused by hemangiomas.

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Section: Others Embolizationmentioning

confidence: 99%

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Master¹,

Kallam²,

Eo³

et al. 2017

J Blood Disord Transfus

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“…High-dose prednisolone (2 mg/kg/day) therapy was successfully used in one case of KMS, 9) but was ineffective in many cases. 8,10,12,13) The response rate to high-dose prednisone (3-8 mg/kg/day) therapy among 11 cases of complex hemangioma was 45%, and the cure rate was 18%. 14) Interferon a2b therapy remains controversial, with a response rate of about 50%.…”

Section: Discussionmentioning

confidence: 99%

“…1) Transarterial embolization is very effective, safe, and an excellent therapeutic option. Successful embolization has been reported with several embolic materials, such as coils, 6) PVA, 8,11,12) and onyx. 15) We achieved an excellent outcome on our patient using transarterial embolization with PVA, which improved the hematological parameters dramatically.…”

Section: Discussionmentioning

confidence: 99%

Transarterial Embolization for Cervical Hemangioma Associated With Kasabach-Merritt Syndrome -Case Report-

Enomoto

Yoshimura

Egashira

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 2-month-old girl presented with cervical hemangioma associated with Kasabach-Merritt syndrome. The patient had previously undergone systemic administration of corticosteroids (prednisolone 2 mg/kg/day) and radiotherapy (0.5 Gy × 5 times), which temporarily increased the platelet count, but the effects were short-lived and thrombocytopenia gradually worsened again despite increased dosage of prednisolone to 5 mg/kg/day. Computed tomography and magnetic resonance imaging revealed a hemangioma in the left retroauricular-cervical region with a well-enhanced, ill-defined margin and bony structure involvement. Diagnostic and therapeutic angiography were carried out through the femoral route under general anesthesia. Polyvinyl alcohol particles (250-350 mm) suspended in contrast medium were slowly injected and a fibered coil was finally placed in the proximal portion of the arterial feeder. Angiography after embolization revealed a marked reduction in the tumor stain. Platelet count rapidly increased and reached the normal range on postembolization day 7. Tumor tension decreased on the day after the procedure and tumor size gradually decreased. The patient was discharged with oral corticosteroid therapy at 6 months postembolization. Corticosteroid dose was gradually decreased and coagulation parameters were normal at 1 year postembolization.

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“…There are also reports of using particles and liquids via the extracranial circulation to treat hemangiomas, arteriovenous fistulas, and neoplasms [5, 6]. A more recent report demonstrates the use of particles for a cervicofacial hemangioma complicated by thrombocytopenia and a consumptive coagulopathy (Kasabach-Merritt Syndrome) [7]. We describe a unique case of a combined internal and external carotid artery approach using PVA embolization, gelatin microspheres, alcohol, and temporary balloon occlusion to treat life threatening epistaxis from a skull base vascular malformation in a three-year-old girl.…”

Section: Introductionmentioning

confidence: 99%

Endovascular Particulate and Alcohol Embolization for Near-Fatal Epistaxis from a Skull Base Vascular Malformation

Koebbe

Horowitz²,

Levy³

et al. 2001

Pediatr Neurosurg

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A three-year old girl who initially presented at 16 months with epistaxis from an anterior skull base vascular anomaly returned with near-fatal epistaxis despite embolization of the internal maxillary artery at the time of initial presentation. Repeat angiography demonstrated blood supply to the vascular lesion coming from branches of both the external and internal carotid arteries. The patient underwent four sessions of endovascular embolization with polyvinyl alcohol, alcohol, and gelatin microspheres. At the conclusion of treatment, her epistaxis had resolved and the only residual blood supply to the lesions came from bilateral ophthalmic arteries intentionally not sacrificed to prevent loss of vision. Endovascular embolization of both the internal and external carotid arteries is a challenging but important treatment option for life-threatening epistaxis resulting from vascular lesions of the skull base.

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Endovascular Treatment of Huge Cervicofacial Hemangioma Complicated by Kasabach-Merritt Syndrome

Cited by 26 publications

References 8 publications

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Transarterial Embolization for Cervical Hemangioma Associated With Kasabach-Merritt Syndrome -Case Report-

Endovascular Particulate and Alcohol Embolization for Near-Fatal Epistaxis from a Skull Base Vascular Malformation

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