Observational data from national and international registries have shown that endovascular repair carries a lower peri-operative mortality risk than open repair for ruptured abdominal aortic aneurysm (AAA). Patient selection may explain the superiority of endovascular aneurysm repair (EVAR), with hostile aortic anatomy being a confounding factor. This study is a meta-analysis of outcomes in patients with hostile vs. friendly aortic anatomy treated for ruptured AAA. It was found that patients with hostile aortic anatomy undergoing EVAR have higher peri-operative mortality and lower overall survival. No significant differences in mortality were found for patients treated by open repair.Objective: To investigate the effect of hostile aortic anatomy on the outcomes of endovascular and open repair for ruptured abdominal aortic aneurysm (AAA). Methods: Electronic bibliographic sources (MEDLINE, EMBASE, CENTRAL) were searched using a combination of thesaurus and free text terms to identify studies comparing treatment outcomes of ruptured AAA in patients with hostile vs. friendly aortic anatomy. A systematic review was conducted that conformed to the PRISMA guidelines using a registered protocol (CRD42019127307). The primary outcomes were peri-operative mortality, freedom from aneurysm related mortality, and overall survival. Pooled estimates of dichotomous outcomes were calculated using odds ratio (OR) and 95% confidence interval (CI). A time to event data metaanalysis was conducted using the inverse variance method and the results were reported as summary hazard ratio (HR) and associated 95% CI. Subgroup analysis for type of treatment (endovascular aneurysm repair [EVAR] or open repair) was undertaken. Random effects models of meta-analysis were developed. Results: Ten observational studies were included reporting a total of 1284 patients (748 with hostile anatomy and 536 with friendly anatomy). Patients with hostile anatomy had a higher peri-operative mortality than patients with friendly anatomy (OR 1.73, 95% CI 1.13e2.66; p ¼ .01). Subgroup analysis showed a significant difference in perioperative mortality in favour of friendly anatomy in patients treated by EVAR (OR 1.76, 95% CI 1.01e3.08; p ¼ .05), but not in those treated by open repair (OR 1.37, 95% CI 0.83e2.27; p ¼ .22). Patients with hostile anatomy treated by EVAR had a significantly higher hazard of death in follow up than patients with friendly aortic anatomy (HR 2.01, 95% CI 1.18e3.44, p ¼ .01), whereas for open surgical repair, the survival was similar in patients with hostile and those with friendly aortic anatomy (HR 0.90, 95% CI 0.61e1.32, p ¼ .58). Conclusion: Hostile aortic anatomy is associated with increased mortality in patients with ruptured AAA treated by EVAR.