Endurance exercise activates matrix metalloproteinases in human skeletal muscle

Rullman, Eric; Norrbom, Jessica; Strömberg, Anna; Wågsäter, Dick; Rundqvist, Helene; Haas, Tara L.; Gustafsson, Thomas

doi:10.1152/japplphysiol.90872.2008

Cited by 99 publications

(132 citation statements)

References 34 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…For example, tenocytes in silicone micropillar gels elevate MMP expression levels in response to gel deformation (Maeda et al, 2013). In addition, humans show dramatic increases in the levels of MMP2, MMP9 and MMP14 in adult tendons following endurance exercise, suggesting that these proteins aid MTJ repair in response to mechanotransduction (Rullman et al, 2009). This effect depends on the timing of loading as, in cultured tendon fascicles, cells upregulate MMP2 and MMP13 after very short cycles of loading, but downregulate MMP1 after longer cycles (Maeda et al, 2009(Maeda et al, , 2013.…”

Section: Mechanical Forces and Signalingmentioning

confidence: 99%

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

2015

View full text Add to dashboard Cite

Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with muscles via the ECM to establish connectivity and strengthen attachments under tension. Similarly, ECM-dependent interactions between tenocytes and cartilage/bone ensure that tendon-bone attachments form with the appropriate strength for the force required. Recent studies have also established a close lineal relationship between tenocytes and skeletal progenitors, highlighting the fact that defects in signals modulated by the ECM can alter the balance between these fates, as occurs in calcifying tendinopathies associated with aging. The dynamic finetuning of tendon ECM composition and assembly thus gives rise to the remarkable characteristics of this unique tissue type. Here, we provide an overview of the functions of the ECM in tendon formation and maturation that attempts to integrate findings from developmental genetics with those of matrix biology.

show abstract

Section: Mechanical Forces and Signalingmentioning

confidence: 99%

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

2015

View full text Add to dashboard Cite

show abstract

“…18 Endurance exercise training has been shown to affect MMP messenger RNA (mRNA), protein and activity in human skeletal muscle. 19 Exercise exerts an effect on MMPs due to multiple potential stimulating factors, such as mechanical loading, 20 local ischaemia 21 and tensile forces in the muscle. 22,23 Exercise-induced angiogenesis requires MMP degradation of the ECM in order to allow for endothelial sprouting.…”

Section: Introductionmentioning

confidence: 99%

Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes

Scheede‐Bergdahl

Bergdahl

Schjerling

et al. 2014

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during vascular remodelling, in both health and disease. Impaired MMP regulation is associated with many diabetes-related complications. This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre-and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.

show abstract

“…This difference reflects the impact of exercise training and may be associated with an inflammatory response (61). Rullman et al (62) reported that endurance exercise enhances MMP-9 but not MMP-2 levels in human skeletal muscle in healthy subjects.…”

mentioning

confidence: 99%

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

et al. 2016

View full text Add to dashboard Cite

Abstract. Matrix metalloproteinases (MMPs) exhibit an important function in extracellular matrix degradation. MMPs modulate the activation of growth factors, cytokines and metastasis. At present, the effect of exercise on serum levels of MMP-2 and -9 remains unclear. The aim of the present study was to investigate the effect of various physical activities on the circulating levels of MMP-2 and -9 in breast cancer (BC) survivors and healthy subjects. A total of 66 female subjects were enrolled in the present study. The cohort included 46 BC survivors and 20 healthy subjects divided into 5 groups: Group A (17 BC survivors, participating in recreational dragon boat paddling), group B (14 BC survivors, participating in recreational physical activity), group C (15 sedentary BC survivors), group D (10 healthy subjects, participating in recreational physical activity) and group E (10 sedentary healthy subjects). ELISA assays revealed a significant increase in the level of circulating MMP-2 in group B compared with all other groups. Recreational physical activity increased the levels of MMP-9 in healthy subjects (group D vs. E), however, the differences were not statistically significant, while in the BC survivor groups the results were opposite, with exercise reducing MMP-9 levels (group B vs. C). Furthermore, a significant increase in MMP-2 was observed in group B lymph node metastasis-positive (N+) subjects compared with group A and C N+ subjects. Thus, the results of the present study indicate that various physical activities modulate the levels of circulating MMP-2 and -9 in BC survivors, and the same exercise program induces a different effect when undertaken by healthy subjects and BC survivors. These results may have important implications with regard to the selection of appropriate physical activities for BC survivors, leading to improvements to their survival and prevention of recurrence, as well as amelioration of physical function, quality of life and fatigue.

show abstract

Endurance exercise activates matrix metalloproteinases in human skeletal muscle

Abstract: Rullman E, Norrbom J, Strö mberg A, Wå gsä ter D, Rundqvist H, Haas T, Gustafsson T. Endurance exercise activates matrix metalloproteinases in human skeletal muscle.

Cited by 99 publications

References 34 publications

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes

Physical exercise modulates the level of serum MMP-2 and MMP-9 in patients with breast cancer

Contact Info

Product

Resources

About