Endurance training and human ??2-adrenergic receptors on platelets

Lockette, Warren; McCurdy, Robert; Smith, S.Y.; Carretero, Oscar A.

doi:10.1249/00005768-198702000-00002

Cited by 7 publications

(1 citation statement)

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“…Our findings of diminished Adra2c and enhanced Nkcc1 gene expression are consistent with expectations based on the literature. We have previously demonstrated that exposure to unpredictable stress reduces the expression of alpha-2 adrenergic receptors, and conversely, exercise training which decreases the catecholamine response to stress, promotes the expression of these receptors in a negative feedback loop 29 . Accordingly, TBI-induced reductions in pre-synaptic alpha-2 adrenergic receptors after TBI could be a direct manifestation of the stress response.…”

Section: Discussionmentioning

confidence: 99%

Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Woodman

Miller

Student

et al. 2023

J Trauma Acute Care Surg

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Section: Discussionmentioning

confidence: 99%

Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Woodman

Miller

Student

et al. 2023

J Trauma Acute Care Surg

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Comparison of sympatho-adrenergic regulation at rest and of the adrenoceptor system in swimmers, long-distance runners, weight lifters, wrestlers and untrained men

Jost

Weiß

Weicker

1989

Europ. J. Appl. Physiol.

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The effects of different physical training regimes on the plasma catecholamine values at rest and the density and responsiveness of adrenergic receptors at rest were investigated. The changes during well-defined training periods of swimmers, long-distance runners, weight lifters and wrestlers were compared with untrained male volunteers. The training of swimmers and long-distance runners, building up endurance, resulted in a significantly lower basal plasma norepinephrine (NE) concentration and a significantly or possibly lower ratio NE:EPI (epinephrine). Both values indicated reduced sympathetic activity and resulted also in a significantly lower beta-receptor density and a higher alpha 2-receptor sensitivity compared with the other groups investigated. However, swimming-specific characteristics provoked labile hypertensive blood pressure regulation with an unchanged heart rate in swimmers. Static training of weight lifters, building up power, also led to a lower NE concentration compared with untrained subjects, whereas beta-receptor density was unchanged and alpha 2-receptor density and sensitivity were decreased. Elevated blood pressure values were observed in weight lifters and swimmers due to a reduced baroreceptor sensitivity. The dynamic training of wrestlers affected only basal heart rate and alpha 2-receptor sensitivity, both of which were decreased. Different kinds of physical training caused various adaptations of the basal activity of the autonomic nervous system in which adrenergic receptors also became adapted. In this context, the stronger adrenergic circulatory component of overall sympathetic activity at rest in swimmers and long-distance runners resulted in lower beta-receptor density, and the reduced noradrenergic component sensitized alpha 2-receptors.

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An alternation in arterial compliance associated with elevated aerobic fitness

Terenzi¹

2000

Journal of Manipulative and Physiological Therapeutics

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Endurance training and human ??2-adrenergic receptors on platelets

Cited by 7 publications

References 0 publications

Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Comparison of sympatho-adrenergic regulation at rest and of the adrenoceptor system in swimmers, long-distance runners, weight lifters, wrestlers and untrained men

An alternation in arterial compliance associated with elevated aerobic fitness

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