Endurance training and L-arginine intake: Their effect on antioxidant indices in the heart muscles of rats

Abstract

Background: One of the side effects of doing sports activities is the increase of free radicals and oxidative stress. Aim: The present study aimed to investigate the effect of 8 weeks of increasing endurance training with L-arginine supplementation on oxidative indices in the cardiac organ of male Wistar rats. Methods: 32 male Wistar rats were divided into four groups control, L-arginine, endurance training, and L-arginine plus endurance training. Animals in the endurance training groups completed increasing endurance training on a motorized treadmill (60-min/session, 5 times/week) for 8 weeks. Animals in the L-arginine groups consumed an L-arginine solution daily (4 mg/kg/body weight). In the supplement group, L-arginine was given to the mice as a solution in water and as a gavage. Forty- eight hours after the last endurance training session, a heart tissue sample was taken and placed in an RNAlater liquid. Spectrophotometry and an ELISA kit were used to calculate the concentrations of glutathione peroxidase (GPX), malondialdehyde (MDA), and superoxide dismutase (SOD). Results: The present study showed that endurance training and L-arginine consumption did not affect SOD activity. L-arginine intake increased GPX. Endurance training caused a significant increase in MDA compared to the supplemented group ( p = 0.01). Also, the consumption of L-arginine significantly increased the total antioxidant capacity TAC in the supplement group compared to the control group ( p = 0.001). Conclusion: It seems that taking an L-arginine supplement can increase antioxidant enzymes.

Modeling of Sports Training Simulation Based on Energy Harvesting in Wireless Sensor Networks

“…Exercise interventions, such as resistance training, have demonstrated their ability to reduce muscle damage even in non-athletic individuals, suggesting potential benefits for improving fitness levels (Mohammed et al, 2022). Moreover, endurance training and L-arginine intake have been investigated for their effects on antioxidant indices in cardiac muscles, indicating their potential role in cardiovascular health (Saifaddin et al, 2023). Similarly, walking exercise and folate supplementation have been explored for their impact on plasma homocysteine levels in elderly non-athletes (Saifalddin et al, 2023).…”