Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease

Steiner, Sabine; Niessner, Alexander; Ziegler, Sophie; Richter, Bernhard; Seidinger, Daniela; Pleiner, Johannes; Penka, M; Wolzt, Michael; Huber, Kurt; Wojta, Johann; Minar, Erich; Kopp, Christoph W.

doi:10.1016/j.atherosclerosis.2005.01.006

Cited by 216 publications

(182 citation statements)

References 22 publications

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“…Most studies investigating the effect of exercise training on the mobilization of EPCs from the BM used aerobic endurance exercise training as intervention strategy (2,44,69,70,74,75,84). No data are available so far on the influence of a pure resistance training on EPC concentration and function.…”

Section: Type Of Exercise-resistance Vs Aerobic Endurance Trainingmentioning

confidence: 99%

“…They could clearly demonstrate that in multivariate regression analysis, the EPC number was an independent risk factor for flow-mediated dilation (FMD) and that the absolute changes of EPC number correlated significantly with changes of FMD before and after treatment. With respect to exercise-induced mobilization of EPC and the improvement in endothelial function, at least two reports are available (74,91). Steiner and colleagues (74) analyzed the impact of aerobic exercise training (12 wk) on endothelial function and EPC content in patients with coronary artery disease.…”

Section: Relationship Between Training-induced Epc Mobilization and Ementioning

confidence: 99%

“…With respect to exercise-induced mobilization of EPC and the improvement in endothelial function, at least two reports are available (74,91). Steiner and colleagues (74) analyzed the impact of aerobic exercise training (12 wk) on endothelial function and EPC content in patients with coronary artery disease. They reported a positive correlation between the improvement of flow-mediated brachial reactivity (⌬FMD) and the relative increase of EPCs.…”

Section: Relationship Between Training-induced Epc Mobilization and Ementioning

confidence: 99%

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Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

Lenk

Uhlemann

Schuler

et al. 2011

Journal of Applied Physiology

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Section: Type Of Exercise-resistance Vs Aerobic Endurance Trainingmentioning

confidence: 99%

Section: Relationship Between Training-induced Epc Mobilization and Ementioning

confidence: 99%

Section: Relationship Between Training-induced Epc Mobilization and Ementioning

confidence: 99%

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Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

Lenk

Uhlemann

Schuler

et al. 2011

Journal of Applied Physiology

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“…Human studies suggest that exercise training leads to sustained whole-body improvement of vascular function, not only within vascular beds of the trained muscle (Green et al, 2002). This relationship is independent of adiposity and the underlying mechanism may be modulated by suppression in systemic inflammation (Steiner et al, 2005). It is speculated that physical inactivity causes a proinflammatory profile as regular muscle contractions mediate signals using messengers to suppress proinflammatory activities at distant sites as well as within the active skeletal muscle (Bruunsgaard, 2005).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory biomarkers are unrelated to endothelial-mediated vasodilation in physically active young men

Aron¹,

Hargens²,

Guill³

et al. 2012

JHSE

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Aron A, Hargens TA, Guill SG, Herbert WG. Inflammatory biomarkers are unrelated to endothelial-mediated vasodilation in physically active young men. J. Hum. Sport Exerc. Vol. 7, No. 2, pp. 581-588, 2012. Endothelial dysfunction has an important role in genesis of atherosclerosis and is depicted by a series of inflammatory and endothelial biomarkers. Shear stress arising from repeated episodes of increased blood flow with physical activity (PA) is a possible mechanism that improves vascular endothelial function. Our purpose was to examine whether inflammatory markers mediate the association between PA and endothelial function. Subjects were young, healthy men recruited according to recreational PA habits: highactive (n=21) vs. sedentary (n=17). Active subjects reported >45 min/day of moderate-vigorous physical activities, >4 days/week over 6 months, while sedentary subjects reported no recreational physical activity. Fasting serum samples were analyzed for C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Endothelial function was determined using flow-mediated dilation of the brachial artery induced by post ischemic reactive hyperemia. Hyperemia response was greater in the high-active than in sedentary men (30.2±8.2 vs. 24.3±5.2 mL/min/100mL; P<0.001). There were no differences between the groups with respect to CRP, TNF-α, or IL-6. Concentrations of these inflammatory biomarkers were unrelated to reactive hyperemia differences attributable to PA. Improved hyperemic response seen in young physically active subjects may be influenced by factors beyond the inflammatory factors, e.g., enhanced nitric oxide production. Physical activity was associated with an increased vascular function in young adults, although a diminished inflammatory state was no revealed. Additional research is needed to clarify the role of PA on cytokine indicators of inflammation and how this relates to endothelial function.

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“…[2][3][4] Data have shown that circulating endothelial progenitor cells (EPCs) contribute to the maintenance of normal endothelial function and impaired EPCs number and function accelerate the impairment of arterial elasticity and endothelial function. [5][6][7][8] Presently, upregulation of circulating EPCs is a novel therapeutic strategy for preventing and treating cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity

Chen

et al. 2007

J Hum Hypertens

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Berberine (BR) has been proved to promote endothelial function. However, the exact mechanisms underlying the effect of BR on endothelial function are not completely clear. It has been demonstrated that endothelial progenitor cells (EPCs) contribute to improvement of endothelial function and C2 small artery elasticity index is a surrogate parameter for the clinical evaluation of endothelial function. We hypothesized that BR-induced mobilization of circulating EPCs is associated with BR-related improvement of endothelial function. To address this assumption, 15 healthy volunteers were recruited and received BR 0.4 g three times per day for 30 days. The number of circulating CD34/KDR double-positive cells as well as C1 large and C2 small artery elasticity indices were evaluated before and after BR therapy. The number of CD34/KDR doublepositive EPCs increased significantly after BR treatment (0.030 ± 0.020% vs 0.017 ± 0.010%, Po0.01). After 30-day BR therapy C2 increased significantly (6.21±2.80 ml per mm Hg Â 100 vs 4.06±2.67 ml per mm Hg Â 100, Po0.01) and C1 remained unchanged (10.79 ± 3.27 ml per mm Hg Â 10 vs 10.06 ± 2.08 ml per mm Hg Â 10, P40.05). The increment of CD34/KDR double-positive EPCs was positively correlated with the increment of C2 (r ¼ 0.68, Po0.01). We concluded that BR-induced mobilization of circulating EPCs contributes to improvement of small artery elasticity in healthy persons.

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Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease

Cited by 216 publications

References 22 publications

Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

Role of endothelial progenitor cells in the beneficial effects of physical exercise on atherosclerosis and coronary artery disease

Inflammatory biomarkers are unrelated to endothelial-mediated vasodilation in physically active young men

Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity

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