Enduring Changes in Dopamine Receptor Cells of Pups from Drug Administration to Pregnant and Nursing Rats

Rosengarten, H; Friedhoff, Arnold J.

doi:10.1126/science.570724

Cited by 202 publications

(57 citation statements)

References 18 publications

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“…The TCB spinners and non-spinners did not differ statistically. With the exception that the TCB non-spinners had lower body weights than controls, these observations are consistent with those of Chou et al [13].…”

Section: General Health and Body Weightssupporting

confidence: 92%

“…Blockade of the DA system in adult animals, by haloperidol for example, can result in an elevation of DA binding capacity [12). However, exposure to haloperidol during gestation can depress DA receptor density [13). Thus, damage to the DA system during early synaptic development may have effects on receptor number that are opposite to those caused by impairment of the adult DA neurons.…”

Section: Discussionmentioning

confidence: 99%

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3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus

1981

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Section: General Health and Body Weightssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus

1981

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“…For example, prenatal and postnatal D2 receptor antagonism with haloperidol decreases D2 expression, behavioral responsiveness to apomorphine and amphetamine, autoreceptor sensitivity, and adenylate cyclase activity [131,180,187,197]. These findings are opposite to what is found following adult chronic neuroleptic exposure [181].…”

Section: The Importance Of Timingcontrasting

confidence: 55%

“…4. Drugs like neuroleptics [180], marijuana and nicotine [67], alcohol, and stimulants [7] have delayed effects that are not apparent until adolescence or later [118]. The adaptive processes underlying these changes is not necessarily qualitatively different than that proposed in the allostasis model of drug abuse [117].…”

Section: The Importance Of Timingmentioning

confidence: 99%

Trajectories of brain development: point of vulnerability or window of opportunity?

Andersen

2003

Neuroscience & Biobehavioral Reviews

1,325

1,006

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Brain development is a remarkable process. Progenitor cells are born, differentiate, and migrate to their final locations. Axons and dendrites branch and form important synaptic connections that set the stage for encoding information potentially for the rest of life. In the mammalian brain, synapses and receptors within most regions are overproduced and eliminated by as much as 50% during two phases of life: immediately before birth and during the transitions from childhood, adolescence, to adulthood. This process results in different critical and sensitive periods of brain development. Since Hebb (1949) first postulated that the strengthening of synaptic elements occurs through functional validation, researchers have applied this approach to understanding the sculpting of the immature brain. In this manner, the brain becomes wired to match the needs of the environment. Extensions of this hypothesis posit that exposure to both positive and negative elements before adolescence can imprint on the final adult topography in a manner that differs from exposure to the same elements after adolescence. This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome. q

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“…The dopaminergic system appears early in brain development of higher species (Voorn et al, 1988), and a neurodevelopmental role for dopamine has been suggested (Rosengarten and Friedhoff, 1979;Miller and Friedhoff, 1986). Dopamine interacts with five dopamine receptor subtypes (D 1 R-D 5 R) having distinct localization and intracellular signaling, allowing this neurotransmitter to exert pleiotropic influences on target cells (Sibley and Monsma, 1992;Gingrich and Caron, 1993;Sokoloff and Schwartz, 1995).…”

Section: Abstract: In Situ Hybridization; Neuroepithelium; Neurogenementioning

confidence: 99%

Selective Expression of Dopamine D₃Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain

et al. 1997

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We studied by in situ hybridization histochemistry the expression of D 3 receptor (D 3 R) mRNA at various stages of rat brain development. The first expression of D 3 R mRNA was detected at embryonic day 14 (E14) in the striatal and rhinencephalic neuroepithelia and throughout the tectal neuroepithelium. From E16 to E19 D 3 R mRNA expression extended along a rostrocaudal axis to additional proliferative ventricular zones of the basal forebrain, including the neuroepithelia of the olfactory bulb, nucleus accumbens, septum, and amygdala, whereas D 1 and D 2 receptor (D 1 R and D 2 R) mRNAs were expressed predominantly by migrating neuroblasts and/or differentiating striatal neurons. Only a few neuroblasts, migrating in the lateral cortical stream or developing as cerebellar Purkinje cells, expressed D 3 R mRNA from E18. At birth D 3 R expression mRNA appeared in differentiating neuronal fields of the nucleus accumbens and medial mamillary body primordia and on P5 reached a distribution similar to that found in adult. In addition, a transient upregulation was detected on P5 in the medial mamillary bodies, parietofrontal cortex, and olfactory tubercle. In the adult brain D 3 R gene expression continued in the striatal proliferative subventricular zone. The late expression D 3 R mRNA in neurons, after achievement of dopamine innervation, supports the existence of a regulating factor released from dopamine neurons, as suggested by denervation studies in the adult. The sustained and abundant D 3 R gene expression, predominantly in germinative neuroepithelial zones actively involved in neurogenesis of most basal forebrain structures, supports the hypothesis of a neurogenetic but minor morphogenetic modulatory role for the D 3 R during CNS development. Key words: in situ hybridization; neuroepithelium; neurogenesis; forebrain development; dopamines; D 3 R mRNACatecholamines seem to affect a number of developmental processes in primitive organisms, including growth, regeneration, and morphogenesis (Lauder, 1993). The dopaminergic system appears early in brain development of higher species (Voorn et al., 1988), and a neurodevelopmental role for dopamine has been suggested (Rosengarten and Friedhoff, 1979;Miller and Friedhoff, 1986). Dopamine interacts with five dopamine receptor subtypes (D 1 R-D 5 R) having distinct localization and intracellular signaling, allowing this neurotransmitter to exert pleiotropic influences on target cells (Sibley and Monsma, 1992;Gingrich and Caron, 1993;Sokoloff and Schwartz, 1995). The D 3 R (Sokoloff et al., 1990) has a density in the adult rat brain two orders of magnitude lower than that of the D 2 R and is expressed in discrete brain regions, including the ventral striatum, mamillary bodies, and archicerebellum (Bouthenet et al., 1991;Lévesque et al., 1992;Diaz et al., 1995).D 1 R and D 3 R both occur in the islands of Calleja and nucleus accumbens (Le Moine and Bloch, 1996), whereas colocalization of D 2 R and D 3 R seems exceptional (Bouthenet et al., 1991). It is not known whether th...

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Enduring Changes in Dopamine Receptor Cells of Pups from Drug Administration to Pregnant and Nursing Rats

Cited by 202 publications

References 18 publications

3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus

3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus

Trajectories of brain development: point of vulnerability or window of opportunity?

Selective Expression of Dopamine D₃Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain

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Enduring Changes in Dopamine Receptor Cells of Pups from Drug Administration to Pregnant and Nursing Rats

Cited by 202 publications

References 18 publications

3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus

3,4,3',4'-Tetrachlorobiphenyl given to mice prenatally produces long-term decreases in striatal dopamine and receptor binding sites in the caudate nucleus

Trajectories of brain development: point of vulnerability or window of opportunity?

Selective Expression of Dopamine D3Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain

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Selective Expression of Dopamine D₃Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain