Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens

Zhang, Xiaoqin; Yu, Zhipeng; Ling, Yu; Zhao, Qiqi; Zhang, Zhongyu; Wang, Zhengchun; Shen, Haowei

doi:10.1007/s00213-019-05284-2

Cited by 10 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These enduring changes are in stark contrast to neuroplastic changes caused by social isolation. Social isolation-dependent brain pathology in PFC, NAc and BLA include: hyperexcitability of NAc neurons (Zhang et al 2019), augmented DA and glutamate neurotransmission in response to rewarding and aversive stimuli (Hall et al 1998;Karkhanis et al 2015Karkhanis et al , 2019, enhanced expression of AMPA, NMDA, DA D2 receptors (Wood et al 2005;Turnock-Jones et al 2009;Han et al 2012;Araki et al 2014) and morphological changes within these regions (Wang et al 2012). These neuroplastic changes are associated with propensity for drug abuse and can be prevented or reversed by EE exposure.…”

Section: Ee Causes Brain Plasticitymentioning

confidence: 99%

Therapeutic efficacy of environmental enrichment for substance use disorders

Galaj

Barrera

Ranaldi

2020

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Section: Ee Causes Brain Plasticitymentioning

confidence: 99%

Therapeutic efficacy of environmental enrichment for substance use disorders

Galaj

Barrera

Ranaldi

2020

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

“…However, we have identified a wide spectrum of changes in gene expression [42] and corresponding alterations in neural network activation levels [13] in prefrontal cortical-striatal circuits due to both NVHLs and sensitizing cocaine regimens, which integrate biologically to generate more extreme addiction-related phenotypes. Evidence for disruptions in dopamine-glutamate signaling in the prefrontal cortex of NVHL rats [43], and abnormal patterns of striatal neuronal excitably in socially isolated rodents (both with [30], and without cocaine exposure [32]) together with the Golgi-staining studies, point to the capacity for NVHL and IMP to work independently and in concert to damage connectivity and in-formation processing capacity in prefrontal-cortical striatal circuits. These conditions might allow the acute and long-term neuroadaptative effects of addictive drugs on prefrontal cortical-striatal circuits (post-synaptic to DA signaling) to have a greater impact on pathologically altering motivated behavior [44,45].…”

Section: Discussionmentioning

confidence: 99%

“…Prolonged living in environments that are relatively deprived of complex stimuli and social contacts has long been known to produce a range of behavioral abnormalities in mammals, as reported in laboratory settings, and in various non-research contexts such as zoos and prisons [24,25]. In parallel with the NVHL model, these environments can have a profound biological impact on neurocircuits and behavior that generate both psychiatric symptoms and addiction vulnerability [26][27][28][29][30] including augmentation of cocaine self-administration [31,32]. The present study is the first to examine the independent and integrated effects of these two forms of brain pathogenesis, on fundamental behavioral measures of mental illness and addiction vulnerability, through adolescence and early adulthood.…”

Section: Introductionmentioning

confidence: 99%

Integrated Effects of Neonatal Ventral Hippocampal Lesions and Impoverished Social-Environmental Rearing on Endophenotypes of Mental Illness and Addiction Vulnerability

Chambers

Sentir

2019

Dev Neurosci

View full text Add to dashboard Cite

A wide range of mental illnesses show high rates of addiction comorbidities regardless of their genetic, neurodevelopmental, and/or adverse-environmental etiologies. Understanding how the spectrum of mental illnesses produce addiction vulnerability will be key to discovering more effective preventions and integrated treatments for adults with addiction and dual diagnosis comorbidities. A population of 131 rats containing a spectrum of etiological mental illness models and degrees of severity was experimentally generated by crossing neonatal ventral hippocampal lesions (NVHL; n = 68) or controls (SHAM-operated; n = 63) with adolescent rearing in environmentally/socially enriched (ENR; n = 66) or impoverished (IMP; n = 65) conditions. This population was divided into 2 experiments: first, examining NVHL and IMP effects on novelty and mild stress-induced locomotion across 3 adolescent ages; second, looking at initial cocaine reactivity and long-term cocaine behavioral sensitization in adulthood. NVHL and IMP-environmental conditions independently produced remarkably similar and robustly significant abnormalities of hyperreactivity to novelty, mild stress, and long-term cocaine sensitization. The combined NVHL-IMP groups showed the most severe phenotypes across the board, so that the mental illness and addiction vulnerability phenotypes increased together in severity in a consistent stepwise progression from the healthiest rats to those with the greatest loading of etiological models. These findings add weight to our understanding of mental illness and addiction vulnerability as brain disorders that are biologically and developmentally unified in ways that transcend etiological causes, and yet co-intensify with increased loading of etiological conditions. Combining neurodevelopmental and adverse-environmental models of mental illness may provide an approach to identifying and therapeutically targeting cortical-striatal-limbic network mechanisms that generate addiction and dual diagnosis diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Alterations in neuronal excitability have been observed in rodents that were socially isolated at both neonatal and stages [11,32,33]. We previously reported that SI increased intrinsic excitability of medium spiny neurons (MSNs) in nucleus accumbens (NAc) [33]. The SI-reared mice at the stage increased the excitatory inputs to fast-spiking parvalbumin-expressing (PV) interneurons and thus increased the ring of PV interneurons [32].…”

Section: Discussionmentioning

confidence: 99%

Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels

Shang,

Dong,

et al. 2023

Mol Neurobiol

Self Cite

View full text Add to dashboard Cite

The recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for mammalian survival and adaptation to a changing environment. Social isolation (SI) has been implicated as a detrimental factor for recognition memory. The medial prefrontal cortex (mPFC) has been shown to carry information concerning the relative familiarity of individual stimuli, and modulating neuronal function in this region may contribute to recognition memory. The present study aimed to investigate the neuronal mechanisms in the mPFC of environmental enrichment (EE) on recognition memory in adult mice following SI. Mice were assigned into three groups: Control, SI, and SI + EE group. Novel location recognition (NLR) and Novel object recognition (NOR) tests were performed to evaluate the recognition memory. The levels of Kv4 channels were assessed by qRT-PCR and Western blotting. The effects of SI and SI + EE on the intrinsic excitability of pyramidal neurons in the mPFC were measured using whole-cell recording. We found that SI led to a reduction in the intrinsic excitability of pyramidal neurons. Speci cally, we have identi ed that the reduction in the ring activity of pyramidal neurons resulted from alterations in the function and expression of Kv4.2 channels. Furthermore, EE regulated Kv4.2 channels, normalized the activity of pyramidal neurons and restored the behavioral de cits following SI. Thus, the roles of Kv4.2 channels in intrinsic excitability of pyramidal neurons suggest that the Kv4.2 channels present a promising therapeutic target for recognition memory impairment.

show abstract

Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens

Cited by 10 publications

References 52 publications

Therapeutic efficacy of environmental enrichment for substance use disorders

Therapeutic efficacy of environmental enrichment for substance use disorders

Integrated Effects of Neonatal Ventral Hippocampal Lesions and Impoverished Social-Environmental Rearing on Endophenotypes of Mental Illness and Addiction Vulnerability

Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels

Contact Info

Product

Resources

About