Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats

Mosaferi, Belal; Babri, Shirin; Ebrahimi, Hadi; Mohaddes, Gisou

doi:10.1016/j.physbeh.2015.02.015

Cited by 22 publications

(37 citation statements)

References 36 publications

(73 reference statements)

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“…EE adolescent mice showed reduced social interaction compared to IE adolescent mice. These effects of EE replicate previous research showing EE reduces locomotor activity (Gehrke et al, ; Lu et al, ), reduces behavioral despair (Mosaferi, Babri, Ebrahimi, & Mohaddes, ), reduces social interaction (Marashi, Barnekow, Ossendorf, & Sachser, ), and increases corticosterone levels (Gehrke et al, ; Lehmann et al, ). Thus, our EE intervention was effective to change behavior as would be expected based on the literature, and the lack of an effect of EE on the behavioral and corticosterone responses to MA suggests that the specific EE paradigm used in this study was not sufficient to provide protection against the behavioral effects of MA.…”

Section: Discussionsupporting

confidence: 85%

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Baker

Magnuson

Dahly

et al. 2018

Developmental Psychobiology

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Methamphetamine alters behavior and the stress response system. Relatively little research has examined the effects of methamphetamine in adolescents and compared these effects to those in adults. Housing in enriched environments has been explored as one way to protect against the effects of methamphetamine, but the findings are conflicting and no study has examined how enriched environment may alter the behavioral and corticosterone responses to methamphetamine in adolescent and adult rodents. We examined the long-term effects of methamphetamine exposure on anxiety, social behavior, behavioral despair, and corticosterone levels in adolescent and adult mice housed in enriched or isolated environments. Enriched environment did not alter the behavioral or corticosterone response to methamphetamine. Methamphetamine exposure decreased anxiety and increased behavioral despair in adult mice, but methamphetamine did not alter behavior in adolescent mice. There was no effect of methamphetamine on social behavior or corticosterone levels. Our findings demonstrate that the specific environmental enrichment paradigm used in this study was not sufficient to mitigate the behavioral effects of methamphetamine and that adolescent mice are relatively resistant to the effects of methamphetamine compared to adult mice.

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Section: Discussionsupporting

confidence: 85%

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Baker

Magnuson

Dahly

et al. 2018

Developmental Psychobiology

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“…Animals in the enriched condition lived in a group of five in a large cage (88 × 82 × 63 cm), furnished with a variety of objects (see Section 2.2). The cages in our laboratory (Mosaferi et al, 2015) were designed according to the previous studies (Simpson and Kelly, 2011). The rats were maintained in their respective cages in a noise-isolated, air-conditioned animal room with constant temperature (22 ± 2 • C) under a regular 12 h light/dark cycle (lights on at 0700 h).…”

Section: Animalsmentioning

confidence: 99%

“…The EC cages were equipped with two running wheels, two food dispensers and two water bottles, and were enriched with a variety of toys (Mosaferi et al, 2015). The internal configuration of the cages was changed every week; creating different spaces with several types of stairs and PVC tubes that the rats could move into or climb over.…”

Section: Environmental Enrichmentmentioning

confidence: 99%

“…Moreover, few studies have focused on the persistence of the effects caused by exposure to enriched environment in a particular life period (Pena et al, 2009). We have recently reported an enduring antidepressive‐like effect in rats reared in an enriched environment compared to those reared in standard and isolated environments 11 weeks after the cessation of the manipulation period (Mosaferi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Post‐weaning environmental enrichment improves BDNF response of adult male rats

Mosaferi

Babri

Mohaddes

et al. 2015

Intl J of Devlp Neuroscience

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The environment could have long lasting effects on the individual phenotype through developmental plasticity. Early environmental enrichment exerts profound biological effects, most of which are quite beneficial ones. To explore the enduring effects of rearing condition quality on BDNF(1) responses, we reared male Wistar rats from weaning to young-adulthood in three different environmental conditions: 1. Enriched 2. Standard, and 3. Isolated. Then, at the age of 16 weeks, 10 rats from each group were randomly chosen and allocated to six common mix cages. They were kept together for 14 weeks. At the end of the experiment, each rat received ten inescapable foot-shocks. Twelve hours later, the BDNF contents of the amygdala and CA1 sub-region of the dorsal hippocampus were measured. The serum BDNF levels, hematocrit values as well as brain and testis weights were also measured. Results showed that the environmental enrichment led to stronger dorsal hippocampal BDNF response and higher serum BDNF levels, while rats from standard laboratory condition showed higher amygdala BDNF response. Also, enriched animals showed higher brain weight compared to isolation reared rats as well as higher testis weight and hematocrit value compared to animals reared in standard laboratory condition. Rats showed less body weights in isolated condition. In conclusion, the BDNF profile of enriched animals might represent the neurobiological correlate of resilience phenotype under a stressful situation.

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“…Extending these observations, the present study describes behavioral and biochemical differences in coping response of the isolated adolescent offspring of pre-reproductively enriched females. It is well-known that in adult rats social isolation has a depressant effect that induces increased immobility in FST, while direct exposure to EE has an antidepressant effect that increases swimming and climbing behaviors (Brenes et al, 2008; Mosaferi et al, 2015). In the current research socially isolated adolescent male pups exhibited reduced body weight and paradoxically decreased passive coping responses (Immobility) regardless of maternal pre-reproductive housing.…”

Section: Discussionmentioning

confidence: 99%

Influence of Pre-reproductive Maternal Enrichment on Coping Response to Stress and Expression of c-Fos and Glucocorticoid Receptors in Adolescent Offspring

Cutuli

Berretta

Pasqualini

et al. 2017

Front. Behav. Neurosci.

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Environmental enrichment (EE) is an experimental setting broadly used for investigating the effects of complex social, cognitive, and sensorimotor stimulations on brain structure and function. Recent studies point out that parental EE experience, even occurring in the pre-reproductive phase, affects neural development and behavioral trajectories of the offspring. In the present study we investigated the influences of pre-reproductive EE of female rats on maternal behavior and adolescent male offspring's coping response to an inescapable stressful situation after chronic social isolation. For this purpose female Wistar rats were housed from weaning to breeding age in enriched or standard environments. Subsequently, all females were mated and housed in standard conditions until offspring weaning. On the first post partum day (ppd 1), mother-pup interactions in undisturbed conditions were recorded. Further, after weaning the male pups were reared for 2 weeks under social isolation or in standard conditions, and then submitted or not to a single-session Forced Swim Test (FST). Offspring's neuronal activation and plastic changes were identified by immunohistochemistry for c-Fos and glucocorticoid receptors (GRs), and assessed by using stereological analysis. The biochemical correlates were measured in the hippocampus, amygdala and cingulate cortex, structures involved in hypothalamic-pituitary-adrenocortical axis regulation. Enriched dams exhibited increased Crouching levels in comparison to standard reared dams. In the offspring of both kinds of dams, social isolation reduced body weight, decreased Immobility, and increased Swimming during FST. Moreover, isolated offspring of enriched dams exhibited higher levels of Climbing in comparison to controls. Interestingly, in the amygdala of both isolated and control offspring of enriched dams we found a lower number of c-Fos immunopositive cells in response to FST and a higher number of GRs in comparison to the offspring of standard dams. These results highlight the profound influence of a stressful condition, such as the social isolation, on the brain of adolescent rats, and underline intergenerational effects of maternal experiences in regulating the offspring response to stress.

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Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats

Cited by 22 publications

References 36 publications

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice

Post‐weaning environmental enrichment improves BDNF response of adult male rats

Influence of Pre-reproductive Maternal Enrichment on Coping Response to Stress and Expression of c-Fos and Glucocorticoid Receptors in Adolescent Offspring

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