Enduring impact of childhood adversity on lower urinary tract symptoms in adult women

Epperson, C. Neill; Duffy, Korrina A.; Johnson, Rachel L.; Sammel, Mary D.; Newman, Diane K.

doi:10.1002/nau.24375

Cited by 16 publications

(28 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Epperson and colleagues conducted a study of women who presented to an academic urology practice or participated in a LUTS prevention study; significant relationships with total LUTS were observed for different family-based traumas (eg, physical abuse, household substance abuse), but not sexual abuse. 4 At least 3 other studies have only found support for associations between childhood sexual trauma and LUTS in adulthood. 6,8,9 The present study adds to literature suggesting that family-based ACEs may impact bladder health and LUTS.…”

Section: Discussionmentioning

confidence: 99%

“…A small number of studies utilizing cross-sectional 4-6 and case-control 7-9 designs have examined whether retrospectively reported ACEs are associated with lower urinary tract symptoms (LUTS). Some studies have found that LUTS are associated with recall of greater numbers of ACEs 4,7 and greater numbers of family-based traumas (eg, physical abuse, household substance abuse), a subset of ACEs. 4,5 In contrast, other studies have found that LUTS are only associated with sexual abuse, a specific type of ACE.…”

mentioning

confidence: 99%

“…Some studies have found that LUTS are associated with recall of greater numbers of ACEs 4,7 and greater numbers of family-based traumas (eg, physical abuse, household substance abuse), a subset of ACEs. 4,5 In contrast, other studies have found that LUTS are only associated with sexual abuse, a specific type of ACE. 6,8,9 Additional research is needed to determine whether ACEs—especially experiences other than sexual abuse—are associated with LUTS in community-based populations.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Adverse Childhood Experiences and Lower Urinary Tract Symptoms and Impact Among Women

et al. 2023

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Adverse Childhood Experiences and Lower Urinary Tract Symptoms and Impact Among Women

et al. 2023

View full text Add to dashboard Cite

“…Neurobiological mechanisms implicate corticotrophin-releasing factor and serotonergic and dopaminergic systems in the pathogenesis of mood disorders and PTSD, and possible links with LUTS. There is a possibility that adverse life events may lead to neurobiological and physiological changes that increase the risk of both mood disorders and somatic disorders, but that the risk factors may be different [ 64 ]. Somatisation may be an adaptive response to psychological distress [ 65 ] and although specific symptoms linked to SA have not been consistently identified [ 66 ], it is plausible that LUTS may be associated with complex PTSD and a manifestation of somatisation linked to SA; however, this needs to be further explored.…”

Section: Discussionmentioning

confidence: 99%

Systematic review exploring the relationship between sexual abuse and lower urinary tract symptoms

et al. 2022

View full text Add to dashboard Cite

Introduction and hypothesis Patients presenting with lower urinary tract symptoms (LUTS) may report a history of sexual abuse (SA), and survivors of SA may report LUTS; however, the nature of the relationship is poorly understood. The aim of this review is to systematically evaluate studies that explore LUT dysfunction in survivors of SA. Methods A systematic literature search of six databases, Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, CINAHL, AMED, and PsycINFO, was performed. The last search date was June 2021 (PROSPERO CRD42019122080). Studies reporting the prevalence and symptoms of LUTS in patients who have experienced SA were included. The literature was appraised according to the PRISMA statement. The quality of the studies was assessed. Results Out of 272 papers retrieved, 18 publications met the inclusion criteria: studies exploring LUTS in SA survivors (n=2), SA in patients attending clinics for their LUTs (n=8), and cross-sectional studies (n=8). SA prevalence ranged between 1.3% and 49.6%. A history of SA was associated with psychosocial stressors, depression, and anxiety. LUTS included urinary storage symptoms, voiding difficulties, voluntary holding of urine and urinary tract infections. Most studies were of moderate quality. Assessment of SA and LUTS lacked standardisation. Conclusions The review highlights the need for a holistic assessment of patients presenting with LUTS. Although most of the studies were rated as being of ‘moderate’ quality, the evidence suggests the need to provide a “safe space” in clinic for patients to share sensitive information about trauma. Any such disclosure should be followed up with further assessment.

show abstract

“…Negative affect can be organized into two broad categories: internalized and externalized negative affect (Martin & Dahlen, 2005). Both internalizing and externalizing negative affect appear to be a consistent correlate and outcome of early adversities (Epperson et al, 2020). Previous research has found early adversities are associated with greater externalized negative affect such as anger (Egeland & Sroufe, 1981;Hoffman-Plotkin & Twentyman, 1984;Lemos-Miller, 2005) and hostility (Greitemeyer & Sagioglou, 2016;Matthews et al, 2010), as well as greater internalized negative affect such as withdrawal (Cole & Putnam, 1992) and shame and guilt (Harter, 1998;Wight et al, 2006).…”

Section: Negative Affectmentioning

confidence: 99%

Early Adversities and Negative Affect in Young Adulthood: Does Family Income Matter?

et al. 2021

View full text Add to dashboard Cite

Previous research has identified increased negative affect as a potential mechanism linking early adversities and later poor mental and physical health. Further, increased self-criticism associated with early adversities may partially explain the association between early adversities and negative affect. Early adversities are more common at lower income levels, and much of the previous research has focused on low-income samples. Hence, little is known about whether the association between early adversities and negative affect is similar across income levels. First, we examine the interactive effect of early adversities and family income on negative affect (anger, hostility, shame and guilt) in a sample of 180 young adults (52% female, 73.6% White, Mage = 21 years). Second, we examine whether self-criticism mediates the association between early adversities and negative affect using moderated mediation analyses. The interaction between early adversities and family income was significant for each outcome. Those from high-income families reported significantly more negative affect when exposed to more early adversities. Further, self-criticism mediated the relationship between early adversities and negative affect, and family income moderated this mediational path such that the mediational effect was stronger at high family income levels. Results are interpreted as consistent with the biological sensitivity to context theory, which suggests individuals from highly supportive and resource rich environments (e.g., high family income) should be more sensitive to stressors than those from moderately supportive, moderately safe environments (e.g., average family income), displaying worse outcomes when exposed to environmental stressors.

show abstract

Enduring impact of childhood adversity on lower urinary tract symptoms in adult women

Cited by 16 publications

References 25 publications

Adverse Childhood Experiences and Lower Urinary Tract Symptoms and Impact Among Women

Adverse Childhood Experiences and Lower Urinary Tract Symptoms and Impact Among Women

Systematic review exploring the relationship between sexual abuse and lower urinary tract symptoms

Early Adversities and Negative Affect in Young Adulthood: Does Family Income Matter?

Contact Info

Product

Resources

About