Enduring Neural and Behavioral Effects of Early Life Adversity in Infancy: Consequences of Maternal Abuse and Neglect, Trauma and Fear

Boulanger-Bertolus, Julie; White, Amanda M.; Dębiec, Jacek

doi:10.1007/s40473-017-0112-y

Cited by 5 publications

(8 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…with mothers and have examined chronic harsh parenting (Boulanger-Bertolus et al, 2017;Kosten et al, 2006;La Buissonnière-Ariza et al, 2019;Machlin et al, 2019;Roth & Sullivan, 2005;Zoicas & Neumann, 2016). Severely negative forms of maternal parenting have been Bertolus et al, 2017;Kosten et al, 2006;La Buissonnière-Ariza et al, 2019;Machlin et al, 2019;Roth & Sullivan, 2005;Zoicas & Neumann, 2016), the current preliminary findings elucidate the role that milder forms of negative parenting may play. It seems, here, that criticism and EOI pose a particular risk for highly anxious children as compared to less anxious children.…”

Section: Discussionmentioning

confidence: 78%

“…Individual trials that were ±2 SD of the global average were considered artifacts and replaced with that participant's global average. Data from subjects who had >20% outlier trials or missing data were excluded from analyses (Boucsein, 2012). Percent signal change values were averaged within stimulus types and phases to assess SCR to the CS+ (whether paired or unpaired) and CS-during preacquisition, acquisition, and extinction.…”

Section: Task Descriptionmentioning

confidence: 99%

See 1 more Smart Citation

Paternal expressed emotion influences psychobiological indicators of threat and safety learning in daughters: A preliminary study

Mullins

Zhou

Glenn

et al. 2021

Developmental Psychobiology

View full text Add to dashboard Cite

This preliminary study examined the association of children's anxiety, paternal expressed emotion (EE), and their interaction with psychophysiological indices of children's threat and safety learning. Participants included 24 father–daughter dyads. Daughters (ages 8–13 years, 100% Latina) self‐reported their anxiety levels and completed a differential threat conditioning and extinction paradigm, during which psychophysiological responding was collected. Fathers completed a Five‐Minute Speech Sample, from which paternal EE (i.e., criticism, emotional overinvolvement) was assessed. Anxiety‐dependent associations emerged between paternal EE and individual differences in daughters’ psychophysiological responding to safety signals during threat conditioning. Paternal EE was positively associated with psychophysiological responding to safety in daughters with high and mean, but not low, levels of anxiety. Although previous work suggests that chronic harsh maternal parenting is a potential risk factor for children's general threat and safety learning, these preliminary findings implicate milder forms of negative parenting behavior in fathers, particularly for highly anxious children.

show abstract

Section: Discussionmentioning

confidence: 78%

Section: Task Descriptionmentioning

confidence: 99%

Paternal expressed emotion influences psychobiological indicators of threat and safety learning in daughters: A preliminary study

Mullins

Zhou

Glenn

et al. 2021

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…At P13, the rat pups' motor skills are more developed and they begin to explore the area surrounding the nest. This is comparable to the toddler stage of human development (Boulanger-Bertolus et al, 2017), when children tend to first receive an ASD diagnosis (Sheldrick et al, 2017).…”

Section: Introductionmentioning

confidence: 82%

Intact maternal buffering of stress response in infant rats despite altered responsivity towards maternal olfactory cues in the valproic acid model of autism-like behavior

White

Dębiec

2022

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Disrupted processing of social cues and altered social behaviors are among the core symptoms of autism spectrum disorders (ASDs), and they emerge as early as the first year of life. These differences in sensory abilities may affect the ability of children with ASDs to securely attach to a caregiver and experience caregiver buffering of stress. Prenatal exposure to valproic acid (VPA) has been used to model some aspects of ASDs in rodents. Here, we asked whether prenatal VPA exposure altered infant rats’ behavioral responsivity to maternal olfactory cues in an Odor Preference Test (OPT) and affected maternal buffering of infants’ stress responsivity to shock. In the odor preference test, 1-week old rats treated with VPA during pregnancy appeared to have impaired social recognition and/or may be less motivated to approach social odors in early infancy. These effects were particularly prominent in female pups. In 2-week old rats, VPA-exposed pups and saline-exposed pups showed similar preferences for home cage bedding. Although VPA-exposed pups may initially have a deficit in this attachment-related behavior they do recover typical responses to home cage bedding in later infancy. Both control and VPA-exposed pups showed robust stress hormone responses to repeated shocks, an effect which was blocked when a calm mother was present during shock exposure. No sex differences in the effect of maternal presence on the stress response to shock and no interactions between sex and prenatal drug exposure were observed. Although VPA-exposed pups may show impaired responsivity to maternal cues in early infancy, maternal presence is still capable of regulating the stress response in VPA-exposed pups. In this study we demonstrate the importance of utilizing multiple batteries of tests in assessing behavior, dissecting the behavior on one test into different components. Our results inform about the underlying behavioral characteristics of some of the ASD phenotypes, including sex differences reported by clinical studies, and could shed light on potential opportunities for intervention.

show abstract

“…It is important to point out that while we described important differences in the emission of USV between infancy and adulthood, the consequences of USV emission on the infant brain remains entirely unknown at this point. Aversive events that induce USV have drastically different consequences at these two stages of development, and their memories also differentially affected the animal’s subsequent behavior [ 159 , 160 ]. The 22-kHz rat vocalizations present an evolutionary counterpart to human crying [ 161 ], and human infant crying and rat pup USV have been suggested to share some similarities [ 72 ].…”

Section: Usv Emission Impacts Brain Activitymentioning

confidence: 99%

Ultrasonic Vocalizations Emission across Development in Rats: Coordination with Respiration and Impact on Brain Neural Dynamics

Boulanger-Bertolus

Mouly

2021

Brain Sciences

Self Cite

View full text Add to dashboard Cite

Rats communicate using ultrasonic vocalizations (USV) throughout their life when confronted with emotionally stimulating situations, either negative or positive. The context of USV emission and the psychoacoustic characteristics of the vocalizations change greatly between infancy and adulthood. Importantly, the production of USV is tightly coordinated with respiration, and respiratory rhythm is known to influence brain activity and cognitive functions. This review goes through the acoustic characteristics and mechanisms of production of USV both in infant and adult rats and emphasizes the tight relationships that exist between USV emission and respiration throughout the rat’s development. It further describes how USV emission and respiration collectively affect brain oscillatory activities. We discuss the possible association of USV emission with emotional memory processes and point out several avenues of research on USV that are currently overlooked and could fill gaps in our knowledge.

show abstract

Enduring Neural and Behavioral Effects of Early Life Adversity in Infancy: Consequences of Maternal Abuse and Neglect, Trauma and Fear

Cited by 5 publications

References 108 publications

Paternal expressed emotion influences psychobiological indicators of threat and safety learning in daughters: A preliminary study

Paternal expressed emotion influences psychobiological indicators of threat and safety learning in daughters: A preliminary study

Intact maternal buffering of stress response in infant rats despite altered responsivity towards maternal olfactory cues in the valproic acid model of autism-like behavior

Ultrasonic Vocalizations Emission across Development in Rats: Coordination with Respiration and Impact on Brain Neural Dynamics

Contact Info

Product

Resources

About