Introduction: In another article written by me, through research in my clinic in Brazil, I concluded that the majority of the population that I am attending is considered immune-deficient due to the lack of energy inside the five internal massive organs (Heart, Spleen, Lungs, Kidney, and Liver). The purpose of this study is to demonstrate that patients with chronic nosocomial osteomyelitis have energy deficiency in the five internal massive organs, that are responsible for the production of Yin, Yang, Qi, and Blood, and the reduction in one or a combination of deficiencies in these energies, can cause the formation of internal Heat, responsible for the yellowish secretion in the bone and not necessarily cause by the bacteria infection. Methods: one case report of a 32 years-old female patient with a history of a motorcycle accident in 2020 with an exposed fracture of the right knee. She was submitted to surgery and after some days, the surgical wound began to have redness in the skin and began to have yellowish secretion through the right knee. She was submitted to the use of many kinds of intravenous antibiotics use with no improvement in her clinical condition of hospital osteomyelitis (meropenem, vancomycin, etc.). She went to my clinic two years later and told me all her history and I performed the measurement of the internal five massive organs’ energy with the use of a crystal pendulum. Results: all her internal five massive organs were in the lowest level of energy, rated one out of eight, with exception of the seventh chakra, that was normal, rated in eight. The treatment consisted in Chinese dietary counseling, auricular acupuncture with apex ear bloodletting and systemic acupuncture and replenishment of the internal massive organs with the use of homeopathy medications according to the theory Constitutional Homeopathy of the Five Elements based on Traditional Chinese Medicine and crystal-based medications. The patient improved from her condition 100% without using any kind of antibiotics. Conclusion: The conclusion of this study is that patients with nosocomial osteomyelitis have energy deficiencies in the five internal massive organs and the treatment using antibiotics and anti-inflammatory medications can reduce even more this vital energy, which is already low, and generate more energy alterations (formation of internal Heat) that are the cause of the symptoms of nosocomial infection or aggravating the evolution of his patient.