Lot of literature is open on performance enhancement of vapour compression & vapour absorption refrigeration system (VCRS & VARS), in any case, investigators have experienced point by point energetic performances investigation in term of COP of VCRS. Researchers is examined the impact of nanofluids on thermal conductivity enhancement. Nevertheless, researchers had not described exergy principle using entropy generation principle for finding the irreversibility computation in components and system exergy destruction ratio (EDRrational) that can be defined as a rational EDR (i.e. which is a ratio of summation of system’s lost work in terms of exergy destruction of all components to exergy of fuel) as well as EDRsystem (i.e. it is a ratio of total lost work to exergy of product) of VCRS using HFO refrigerants (i.e.R1225ye(Z)) This paper primarily deals with comparison between three nano particles that are utilized in minor circuit of cooling heat exchanger, which improves cooling temperature as a result of enhance in COP. enhancement in first law efficiency (i.e. COP) by using CuO, Al2O3, & TiO2 was evaluated to be as 18.48%, 17.47%, & 15.95%, respectively alongside enhancement in cooling heat exchanger overall heat transfer coefficient by using CuO, Al2O3, & TiO2 was about 107.66%, 98.6%, & 86.4%, respectively. Similarly, enhancement in condenser overall heat transfer coefficient by using CuO, Al2O3, & TiO2 was about 11.24%, 10.77%, & 9.94%, respectively. Also, enhancement in exergetic performance by using CuO, Al2O3, & TiO2 was about 13.93 %, 12.94 %, & 11.49%, respectively.