The overlap between large distributed simulations and real-time applications
[1][2][3] has been always present, and it is increasing fast recently because of the circumstances raised from the current new trends, such as Cloud computing
[4,5], intelligent transportation systems
[1,6], green computing
[7,8], and virtual environments
[2,9]. As the overlap increases, new challenges appear, mostly for enabling applications, like serious gaming
[10], virtual and augmented reality, and collaborative virtual environments
[11], to execute seamlessly on distributed resources
[12][13][14].
This special issue intends to collect the state-of-the-art research works that include a set of concepts on high performance computing; design, modeling, and validation of distributed real-time systems; and multi-agent control and simulation systems.