This study aims to assess the feasibility and performance, as well as the exergy loss, of utilizing ejectors in absorption–compression cascade configurations for low-temperature refrigeration systems. The coefficient of performance (COP) is used to measure system efficiency, including COP.A (COP of the absorption chiller), COP.C (COP of the compression side) and COP.Ca (COP of the cascade configuration). The results highlight the importance of ejector placement on the absorption side for optimal performance. Configuration D1, with an ejector on the absorption side, demonstrates an 85% improvement in COP.A, approximately 10% in COP.C and nearly 100% in COP.Ca compared to configurations without an ejector. However, in certain cases, using an ejector on the compression side is not feasible from a second-law perspective, particularly for higher compression-side evaporator temperatures. Nonetheless, the study suggests that configuration D0, which includes an ejector on the absorption side coupled with a simple compression cycle, is applicable for these conditions and performs similarly to D1 in other temperature ranges. These findings provide valuable insights for optimizing ejector placement in absorption–compression cascade configurations and advancing the development of more energy-efficient refrigeration systems.