MESSAGEix model are widely used for forecasting long-term energy consumption and emissions, as well as modelling the possible GHGs mitigations. However, because of the complexity of manufacturing sectors, the MESSAGEix model aggregate detailed technology options and thereby miss linkages across sub-sectors, which leads to energy saving potentials are often not very realistic and cannot be used to design specific policies. Here, we integrate Material/Energy/water Flow Analysis (MEWFA) and nexus approach into the MESSAGEix to estimate resource-energy-environment nexus in China's iron and steel industry. Results show that between 2010 and 2050 energy efficiency measures and route shifting of China's steel industry will decrease raw material input by 14%, energy use by 7%, water consumption by 8%, CO 2 emissions by 7%, NOx emissions by 9%, and SO 2 emissions 1