Fuel consumption optimization is a critical field of research within the automotive industry to meet consumer expectations and regulatory requirements. A reduction in fuel consumption can be achieved by reducing the energy consumed by the vehicle. Several subsystems contribute to the overall energy consumption of the vehicle, including the air conditioning (A/C) system. The loads within the A/C system are mainly contributed by the compressor, condenser fan, and underhood aerodynamic drag, which are the components targeted for overall vehicle energy use reduction in this paper. This paper explores a new avenue for A/C system control by considering the power consumption due to vehicle drag (regulated by the condenser fan and active grille shutters (AGS)) to reduce the energy consumption of the A/C system and improve the overall vehicle fuel economy. The control approach used in this paper is model predictive control (MPC). The controller is designed in Simulink, where the compressor clutch signal, condenser fan speed, and AGS open-fraction are inputs. The controller is connected to a high-fidelity vehicle model in Gamma Technologies (GT)-Suite (which is treated as the real physical vehicle) to form a software-in-the-loop simulation environment, where the controller sends actuator inputs to GT-Suite and the vehicle response is sent back to the controller in Simulink. Quadratic programming is used to solve the MPC optimization problem and determine the optimal input trajectory at each time step. The results indicate that using MPC to control the compressor clutch, condenser fan, and AGS can provide a 37.6% reduction in the overall A/C system energy consumption and a 32.7% reduction in the error for the air temperature reference tracking compared to the conventional baseline proportional integral derivative control present in the GT-Suite model.