This paper brings together the benefits of the results of exergy, exergoeconomic, exergoenvironmental analysis, and optimization for a waste-to-energy power plant. Initially, exergoeconomic balances for each stream were calculated. For validating the current simulations, the actual data of the Amsterdam waste-to-energy power plant in working conditions were examined. Moreover, the behaviors of the influential parameters on the objective functions were evaluated. In order to perform multi-objective optimization, the Multi-Objective Particle-Swarm Optimization algorithm is implemented. To obtain optimum operating conditions, 14 design parameters, and 3 objective functions are considered, while the total cost rate, total exergy efficiency of the cycle, and environmental impacts are the objective functions. Finally, the TOPSIS decision-making method determined optimum-operating conditions. The results of exergy analysis indicated that the most exergy destruction belonged to the incinerator unit at 66%. Instead, the pumps contributed the least in this field, (approximately 1%). Because of the optimization process, the total exergy efficiency of the power plant increased from 30.89% to 38.9% while the total cost rate was 5188.05 USD/hour. By comparison between the obtained results from the optimization procedure, introducing optimum working condition has caused an increase in exergy efficiency and reduced exergy destruction for components.