Energy expenditure and the body cell mass in cystic fibrosis

Shepherd, Ross W.; Greer, Ristan M.; McNaughton, Sarah A.; Wotton, M.; Cleghorn, Geoffrey J.

doi:10.1016/s0899-9007(00)00470-6

Cited by 37 publications

(23 citation statements)

References 21 publications

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“…Benefits of moderate intensity exercise for patients with CF have been demonstrated, especially in relation to improved sputum expectoration [30]. On the other hand, an elevated rest energy expenditure, compared to normal levels, have been documented in individuals with CF [31] and chronic obstructive pulmonary disease [32], since it is associated with the severity of changes in pulmonary physiology [33]. The results presented in this review indicate that energy expenditure values are higher during video game activities in comparison to the tests or exercise used.…”

Section: Discussionmentioning

confidence: 99%

Physiological responses during exercise with video games in patients with cystic fibrosis: A systematic review

Carbonera

Vendrusculo

Donadio

2016

Respiratory Medicine

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Section: Discussionmentioning

confidence: 99%

Physiological responses during exercise with video games in patients with cystic fibrosis: A systematic review

Carbonera

Vendrusculo

Donadio

2016

Respiratory Medicine

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“…Thus, information about protein turnover gathered from children with CF may not be relevant in CF adults. While normal rates of protein breakdown are described for well-nourished CF children (20,44,45), there are several reports of increased protein catabolism in malnourished growth-retarded children with CF (20,44,46,47). This latter finding may be more related to infection than to poor nutritional status, since malnourished children identified as being free of infection had normal protein breakdown (45).…”

Section: Figmentioning

confidence: 99%

Protein Metabolism in Clinically Stable Adult Cystic Fibrosis Patients With Abnormal Glucose Tolerance

et al. 2001

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In contrast, striking abnormalities were seen in CF patients when insulin was infused, since they did not experience normal suppression of the appearance rates of leucine, phenylalanine, or tyrosine (indexes of protein breakdown). At an insulin concentration of 45 ؎ 2 U/ml, normal control subjects suppressed the leucine appearance rate by 19 ؎ 5% (P < 0.01), ketoisocaproate appearance rate by 10 ؎ 3% (P ‫؍‬ 0.03), tyrosine appearance rate by 11 ؎ 2% (P ‫؍‬ 0.03), and phenylalanine appearance rate by 6 ؎ 3% (P ‫؍‬ 0.07). Phenylalanine conversion to tyrosine decreased by 22 ؎ 7% (P ‫؍‬ 0.03). At a similar insulin concentration of 44 ؎ 3 U/ml, normal suppression of amino acid appearance did not occur in CF. The leucine appearance rate decreased by 4 ؎ 2% (P ‫؍‬ 0.65), ketoisocaproate appearance rate by 1 ؎ 2% (P ‫؍‬ 0.94), tyrosine appearance rate by 0 ؎ 6% (P ‫؍‬ 0.56), phenylalanine appearance rate by 5 ؎ 6% (P ‫؍‬ 0.34), and phenylalanine conversion to tyrosine by 5 ؎ 6% (P ‫؍‬ 0.95). Poor suppression of the amino acid appearance rate in CF was not related to previously documented glucose tolerance status (IGT or CF-related diabetes without fasting hyperglycemia), fasting insulin levels, the acute insulin response, insulin sensitivity, cytokine or counterregulatory hormone levels, resting energy expenditure, caloric intake, pulmonary function, or clinical status. Protein synthesis was not significantly affected by insulin infusion in either normal control subjects or CF patients. In conclusion, clinically stable adult CF patients have normal indexes of protein breakdown and synthesis in the fasting state. In contrast, elevation of plasma insulin to physiological postprandial levels fails to normally suppress indexes of protein breakdown. It is therefore likely that inability to spare protein during the postprandial state is the cause of protein catabolism in these patients. Diabetes

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“…In particular, resting energy expenditure (REE) appears to be increased per unit cell mass in malnourished children with CF [4 -8], which cannot be completely explained by pulmonary inflammation [4]. Nevertheless, the later development of abnormal pulmonary mechanics may cause further increases with age [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Energy cost of activity and exercise in children and adolescents with cystic fibrosis

Johnson

Ferkol

Shepherd

2006

Journal of Cystic Fibrosis

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Energy expenditure and the body cell mass in cystic fibrosis

Cited by 37 publications

References 21 publications

Physiological responses during exercise with video games in patients with cystic fibrosis: A systematic review

Physiological responses during exercise with video games in patients with cystic fibrosis: A systematic review

Protein Metabolism in Clinically Stable Adult Cystic Fibrosis Patients With Abnormal Glucose Tolerance

Energy cost of activity and exercise in children and adolescents with cystic fibrosis

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