Energy expenditure in infants with congenital heart disease, including a meta-analysis

KR, Westerterp; RJBJ, Gemke; Meer, K de; Kuip, Martijn van der; MB, Hoos; PP, Forget

doi:10.1080/08035250310003569

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…There are likely multiple mechanisms contributing to growth failure in this population including chronic cyanosis, alterations in energy expenditure (14, 15), inadequate caloric intake (16, 17), genetic factors (18), and alterations in serum growth factors and growth hormone (19). It can be difficult to achieve adequate nutrition in neonates with single ventricle physiology who typically undergo complex surgical palliation within the first few days to weeks of life, with further surgical palliation within the first year of life.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Growth in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial

Williams

Zak

Ravishankar

et al. 2011

The Journal of Pediatrics

101

122

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Objectives To describe growth patterns in infants with single ventricle physiology and determine factors influencing growth. Study design Data from 230 subjects enrolled in the Pediatric Heart Network Infant Single Ventricle Enalapril Trial were used to assess factors influencing change in weight-for-age z-score (Δz) from study enrollment (0.7 ± 0.4 months) to pre-superior cavopulmonary connection (SCPC) (5.1 ± 1.8 months, period 1), and pre-SCPC to final study visit (14.1 ± 0.9 months, period 2). Predictor variables included patient characteristics, feeding regimen, clinical center, and medical factors during neonatal (period 1) and SCPC hospitalizations (period 2). Univariate regression analysis was performed, followed by backward stepwise regression and bootstrapping reliability to inform a final multivariable model. Results Weights were available for 197/230 subjects for period 1 and 173/197 for period 2. For period 1, greater gestational age, younger age at study enrollment, tube feeding at neonatal discharge, and clinical center were associated with a greater negative Δz (poorer growth) in multivariable modeling (adjusted R2 = 0.39, p < 0.001). For period 2, younger age at SCPC and greater daily caloric intake were associated with greater positive Δz (better growth) (R2 = 0.10, p = 0.002). Conclusions Aggressive nutritional support and earlier SCPC are modifiable factors associated with a favorable change in weight-for-age z-score.

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Section: Discussionmentioning

confidence: 99%

Factors Affecting Growth in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial

Williams

Zak

Ravishankar

et al. 2011

The Journal of Pediatrics

101

122

View full text Add to dashboard Cite

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Disturbance of Glucose Homeostasis After Pediatric Cardiac Surgery

et al. 2010

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This study aimed to evaluate the time course of perioperative blood glucose levels of children undergoing cardiac surgery for congenital heart disease in relation to endogenous stress hormones, inflammatory mediators, and exogenous factors such as caloric intake and glucocorticoid use. The study prospectively included 49 children undergoing cardiac surgery. Blood glucose levels, hormonal alterations, and inflammatory responses were investigated before and at the end of surgery, then 12 and 24 h afterward. In general, blood glucose levels were highest at the end of surgery. Hyperglycemia, defined as a glucose level higher than 8.3 mmol/l (>150 mg/dl) was present in 52% of the children at the end of surgery. Spontaneous normalization of blood glucose occurred in 94% of the children within 24 h. During surgery, glucocorticoids were administered to 65% of the children, and this was the main factor associated with hyperglycemia at the end of surgery (determined by univariate analysis of variance). Hyperglycemia disappeared spontaneously without insulin therapy after 12–24 h for the majority of the children. Postoperative morbidity was low in the study group, so the presumed positive effects of glucocorticoids seemed to outweigh the adverse effects of iatrogenic hyperglycemia.

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Energy expenditure in infants with congenital heart disease, including a meta-analysis

Cited by 2 publications

References 16 publications

Factors Affecting Growth in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial

Factors Affecting Growth in Infants with Single Ventricle Physiology: A Report from the Pediatric Heart Network Infant Single Ventricle Trial

Disturbance of Glucose Homeostasis After Pediatric Cardiac Surgery

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