Energy Homeostasis, Obesity and Eating Disorders: Recent Advances in Endocrinology

Gale, Susan M.; Castracane, V. Daniel; Mantzoros, Christos S.

doi:10.1093/jn/134.2.295

Cited by 236 publications

(160 citation statements)

References 33 publications

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“…Twin studies have clearly demonstrated a genetic risk, 9 and the discovery of leptin, ghrelin, adiponectin, and other hormones that influence appetite, satiety, and fat distribution provides insight into metabolic mechanisms for physiologic risk. 10 With multiple substances and multiple gene sites associated with obesity, the system is complex, redundant, and likely not amenable to a simple pharmaceutical intervention. However, genes are not destiny.…”

Section: Causesmentioning

confidence: 99%

Expert Committee Recommendations Regarding the Prevention, Assessment, and Treatment of Child and Adolescent Overweight and Obesity: Summary Report

2007

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To revise 1998 recommendations on childhood obesity, an Expert Committee, comprised of representatives from 15 professional organizations, appointed experienced scientists and clinicians to 3 writing groups to review the literature and recommend approaches to prevention, assessment, and treatment. Because effective strategies remain poorly defined, the writing groups used both available evidence and expert opinion to develop the recommendations. Primary care providers should universally assess children for obesity risk to improve early identification of elevated BMI, medical risks, and unhealthy eating and physical activity habits. Providers can provide obesity prevention messages for most children and suggest weight control interventions for those with excess weight. The writing groups also recommend changing office systems so that they support efforts to address the problem. BMI should be calculated and plotted at least annually, and the classification should be integrated with other information such as growth pattern, familial obesity, and medical risks to assess the child's obesity risk. For prevention, the recommendations include both specific eating and physical activity behaviors, which are likely to promote maintenance of healthy weight, but also the use of patient-centered counseling techniques such as motivational interviewing, which helps families identify their own motivation for making change. For assessment, the recommendations include methods to screen for current medical conditions and for future risks, and methods to assess diet and physical activity behaviors. For treatment, the recommendations propose 4 stages of obesity care; the first is brief counseling that can be delivered in a health care office, and subsequent stages require more time and resources. The appropriateness of higher stages is influenced by a patient's age and degree of excess weight. These recommendations recognize the importance of social and environmental change to reduce the obesity epidemic but also identify ways healthcare providers and health care systems can be part of broader efforts.www.pediatrics.org/cgi

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Section: Causesmentioning

confidence: 99%

Expert Committee Recommendations Regarding the Prevention, Assessment, and Treatment of Child and Adolescent Overweight and Obesity: Summary Report

2007

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“…Energy homeostasis, the delicate balance between ATP production and consumption, is very critical for many cellular processes (47). Several serious disorders such as cancer and obesity involve the dysregulation of ATP balance in the cellular level and energy homeostasis at the whole body.…”

Section: Endostatin Regulates Intracellular Atp Levelsmentioning

confidence: 99%

Endostatin Has ATPase Activity, Which Mediates Its Antiangiogenic and Antitumor Activities

Wang

Liu

et al. 2015

Molecular Cancer Therapeutics

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Endostatin is an endogenous angiogenesis inhibitor with broad-spectrum antitumor activities. Although the molecular mechanisms of endostatin have been extensively explored, the intrinsic biochemical characteristics of endostatin are not completely understood. Here, we revealed for the first time that endostatin embedded novel ATPase activity. Moreover, mutagenesis study showed that the ATPase activity of endostatin mutants positively correlated with effects on endothelial cell activities and tumor growth. E-M, an endostatin mutant with higher ATPase activity than that of wild-type (WT) endostatin, significantly increased endostatin-mediated inhibitory effects on endothelial cell proliferation, migration, tube formation, and adhesion. In vivo study showed that E-M displayed enhanced antitumor effects compared with WT. On the other hand, K96A, K96R, and E176A, endostatin mutants with lower ATPase activities than that of WT, showed reduced or comparable effects on targeting both in vitro endothelial cell activities and in vivo tumor angiogenesis and tumor growth. Furthermore, endostatin and its mutants exhibited distinct abilities in regulations of gene expression (Id1, Id3), cell signaling (Erk, p38, and Src phosphorylation), and intracellular ATP levels. Collectively, our study demonstrates that endostatin has novel ATPase activity, which mediates its antiangiogenic and antitumor activities, suggesting that construction of endostatin analogues with high ATPase activity may provide a new direction for the development of more potent antiangiogenic drugs.

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“…Discovered in 1999, ghrelin is a potent hunger-inducing peptide hormone (Kojima et al, 1999). Once ghrelin was cloned and isolated from rat and human gut, assays indicate that it activates the receptor for growth hormone secretagogues, and regulates feeding behavior and energy metabolism through central activity (Horvath et al, 2001;Korner and Leibel, 2003;Gale et al, 2004). In particular, ghrelin enhances fat mass deposition and increases food intake by modulating hypothalamic appetite-regulating pathways through promotion of neuropeptide Y (NPY) and Agouti-related protein expression.…”

Section: Introductionmentioning

confidence: 99%

Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin

Jin

Meyer

Mudaliar

et al. 2008

Schizophrenia Research

131

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Background-Many adverse effects of atypical antipsychotic treatment are associated with antagonism of monoamine receptors; however, data indicate that important metabolic effects, such as hypertriglyceridemia and impairment in glucose/insulin homeostasis, may not be related to these mechanisms, leading investigators to explore alternative hypotheses. Promising candidates include a possible impact of antipsychotics on peptide hormonal regulators of metabolic control such as leptin, ghrelin, and adiponectin. The purpose of this review is to summarize recent data on changes in these hormones during atypical antipsychotic treatment.

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Energy Homeostasis, Obesity and Eating Disorders: Recent Advances in Endocrinology

Cited by 236 publications

References 33 publications

Expert Committee Recommendations Regarding the Prevention, Assessment, and Treatment of Child and Adolescent Overweight and Obesity: Summary Report

Expert Committee Recommendations Regarding the Prevention, Assessment, and Treatment of Child and Adolescent Overweight and Obesity: Summary Report

Endostatin Has ATPase Activity, Which Mediates Its Antiangiogenic and Antitumor Activities

Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin

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