2014
DOI: 10.1172/jci77126
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Energy homeostasis targets chromosomal reconfiguration of the human GH1 locus

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Cited by 12 publications
(14 citation statements)
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“…To our knowledge, this is the first study to use a murine system to observe the effect of SD on hGH synthesis, as studies on hGH-N RNA levels in the pituitary are not possible in living humans. As expected, the consumption of a HFD for three to four days did not cause significant weight gain (12,13), but there was evidence of stress due to acute SD that was independent of diet.…”
Section: Discussionsupporting
confidence: 73%
“…To our knowledge, this is the first study to use a murine system to observe the effect of SD on hGH synthesis, as studies on hGH-N RNA levels in the pituitary are not possible in living humans. As expected, the consumption of a HFD for three to four days did not cause significant weight gain (12,13), but there was evidence of stress due to acute SD that was independent of diet.…”
Section: Discussionsupporting
confidence: 73%
“…In the thyroid, 133 autosomal genes were sex-biased, 75% of which were expressed more highly in males. Genes that encode for growth factors and signaling molecules were highly expressed in the thyroid of males, such as CCL28 , a growth factor in hematopoietic stem cells (Karlsson et al, 2013 ), CMTM4 , a chemokine that regulates the cell cycle (Plate et al, 2010 ), and GH1 , a gene that encodes for growth hormone (Vakili et al, 2014 ). These findings suggest a functional role for the thyroid in influencing sexually dimorphic traits such as metabolism, as well as sex differences in thyroid hormone secretion (Ehrenkranz et al, 2015 ).…”
Section: Resultsmentioning
confidence: 99%
“…Disruption of the Pit-1 complex and chromosomal loop, including through a high fat vs regular chow diet in partially humanised 171 hGH/CS transgenic mice, has a negative effect on hGH-N/GH1 expression. 67,70,71 To date, no placenta-specific factor, equivalent to pituitary-specific Pit-1 and capable of binding hPL LCR and gene promoter sequences, has been identified. However, the zinc finger DNA-binding transcription factor paternally-expressed gene 3 (PEG3/PW1), the imprinted gene product of the paternal allele, has emerged as a potential candidate.…”
Section: Peg3/pw1: a P Oss Ib Le C And Idate For Pl Acental Controlmentioning
confidence: 99%