Energy level and sleep quality following bone marrow transplantation

Abstract

Summary:endpoint following BMT. QOL is a multidimensional concept incorporating aspects of an individual's physical health, personal, cognitive, and occupational functioning, While problems with sleep and energy level (ie fatigue) are commonly reported during recovery from bone sociability, and feelings of personal distress and wellbeing. 1-2 A number of excellent reports investigating one marrow transplantation (BMT), little in-depth information regarding these two problem areas in BMT or more dimensions of QOL in adult BMT recipients have appeared in recent years. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] In general, these studies sugpatients is available. Using both questionnaire and telephone interview methods, information regarding curgest that while many BMT recipients evidence a relatively normal QOL following BMT, significant numbers of adult rent sleep and energy level problems was obtained from 172 adult BMT survivors drawn from five different BMT recipients report deficits in one or more QOL domains. These deficits span a range of QOL domains and BMT treatment centers. Respondents were a mean of 43.5 months post-BMT at the time of the initial assesscan persist for years following BMT.Sleep problems and problems with fatigue, reduced ment. Similar questionnaire data was obtained from 137 respondents (80%) at a follow-up assessment 18 months energy level, or loss of stamina or strength are two areas of QOL deficit which have been identified as significant after the initial assessment. Results suggested that half to two-thirds of disease-free BMT recipients experience concerns following BMT. In a study of 125 adult long-term survivors (6-18 years) of BMT, fatigue (56% of sample) problems with regard to current energy level or sleep quality. While for the majority of patients these proband sleep disturbance (43%) were two of the three most frequently reported current physical problems. 8 Greater age lems were rated as mild, 15-20% of BMT recipients showed moderate to severe problems in these areas with at BMT was significantly associated with greater current fatigue. In a study of 135 adult BMT recipients (6-149 corresponding decrements in quality of life. Furthermore, both cross-sectional and longitudinal analyses months post-BMT), among 18 life domains rated, 'strength' was the domain with which patients were least satisfied.7 suggested that problems in these areas did not simply abate with time. Only low to moderate correlations were In another study, 23% of 162 adult long-term survivors (1 to 13 years post-BMT) of allogenic BMT reported 'variobtained between indices of sleep and energy problems and measures of anxious and depressed mood. Finally, able' or 'poor' sleeping habits. 14 Similarly, 27% of 59 adult autologous BMT recipients reported poor or variable sleep the presence of current sleep problems was associated with older age at BMT, receipt of TBI during pre-BMT habits 1 year following BMT. 9 Syrjala et al 15 reported that 27% of 31 patients 1 year post-allogeneic BMT scored in co...

Sleep disturbances and emotional distress in the acute course of hematopoietic stem cell transplantation

“…According to this study sleep difficulties are most frequently attributed to environmental factors (noises, care delivered by the nursing staff, illumination), anxiety, depression and nervousness. 29 Our findings are also consistent with the results from Andrykowski et al, 15 who examined the sleep quality of BMTsurvivors 12-124 months post-transplantation. They show sleep disturbances to be most often caused by the need to use the bathroom.…”

“…37,38 In our study, female patients did not differ significantly from males regarding anxiety and/or depression. The literature is inconsistent regarding this issue: some studies show a better sleep quality of men, 15,39 whereas others describe no differences regarding concerning gender. 6,36,40 Our results indicate different temporal courses of sleep quality regarding the type of transplant.…”

“…At T1 the physical functioning of older participants was even better. Studies that deal with sleep quality of BMT/PBSCT patients and distinguish between young and old patients describe different results: some show a better sleep quality in younger patients, 13,15 whereas others show no significant differences of sleep quality regarding age. 6,[34][35][36] Sleep disturbances of women within the general population are mainly ascribed to a higher frequency of anxiety/depression and to hormonal changes during menstrual cycle, pregnancy and postmenopause.…”

“…Studies in the long-term follow-up or studies among other populations show the importance of difficulties in maintaining sleep. Andrykowski et al 15 describe multiple awakenings as the most frequently complained sleep difficulty. However, the authors ask for difficulties in maintaining sleep only in correspondence with early awakening.…”

“…The studies note that the proportion of patients with good sleep varies about 55-80%, but that observed sleep difficulties are significantly worse compared with a healthy comparison group. [12][13][14] Andrykowski et al 15 analyzed the sleep quality of patients who received BMT 12-124 months ago. They found that approximately half of the participants had mild sleep difficulties.…”