Energy management – a critical role in cancer induction?

Re-thinking the Networks

“…In Figure 2, signalling is presented as amalgamation of entropic "corridors" derived from micro-domains. The dynamic behaviour of entropy "maps" is illustrated by Mandelbrot figures (Figure 3) where shapes seamlessly metamorphose into others of the same profile, thus creating many signalling environments simultaneously ( [1] contains a link to a video clip of this metamorphosis). It also proposes that origins of signalling are chaotic, i.e., highly dependent on, but not proportional to, initial conditions.…”

“…Reproduced from reference [1] by kind permission of Elsevier Press. Glycol=Glycolysis; E.R=Endoplasmic Reticulum Upper: Cells exist as non-bounded microdomains (shaded motifs), each having multiple entry and exit points connected by fractal energy dissipation.…”

“…Cell specificity is a separate issue but clearly the expression of cell phenotype is determined by signalling networks and herein lie some problems. Figure 1 presents a stylised diagram of a signal transduction pathway, in this case generically dealing with cancer induction (reproduced from reference [1]). This article addresses the issue that while the "signalling" agents inducing cancer are extremely variable, cancer cells all express the same progressive attributes.…”

“…Reproduced by kind permission of Elsevier Press from reference [1]. Upper: Signalling is represented by dimensionless, progressive and sequential vectorial arrays.…”

“…These considerations have been formulated into a model of Fractal Entropy applied to the origin of cancer (reference [1] and Figure 2). In Figure 2, signalling is presented as amalgamation of entropic "corridors" derived from micro-domains.…”