Energy Metabolic Disorder of Astrocytes May Be an Inducer of Migraine Attack

Li, Junhua; Ye, Xiaotong; Zhou, Yang; Peng, Siyun; Zheng, Peibing; Zhang, Xiaoxiao; Yang, Jiajun; Xu, Yanhong

doi:10.3390/brainsci12070844

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…Increased NO and CGRP levels cause harm to the respiratory chain of the mitochondria, reduce ATP synthesis, and generate substantial quantities of ROS. This causes oxidative stress and damaged neurons, which can trigger migraine headaches ( 48 – 51 ). NO and CGRP expression are also impacted by mitochondrial malfunction and excessive ROS generation, and these elements combine to cause migraine ( 42 , 52 – 54 ).…”

Section: Discussionmentioning

confidence: 99%

Association of dietary vitamin C consumption with severe headache or migraine among adults: a cross-sectional study of NHANES 1999–2004

Zheng,

Jin,

Wei

et al. 2024

Front. Nutr.

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BackgroundAn antioxidant-rich diet has been shown to protect against migraines in previous research. However, little has been discovered regarding the association between migraines and vitamin C (an essential dietary antioxidant). This study assessed the dietary vitamin C intake among adult migraineurs in the United States to determine if there is a correlation between migraine incidence and vitamin C consumption in adults.MethodsThis cross-sectional research encompassed adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004, providing detailed information on their dietary vitamin C intake as well as their history of severe headaches or migraines. The study used weighted multivariable and logistic regression analyses to find an independent connection between vitamin C consumption and severe headache or migraine. Tests of interactions and subgroup analysis were conducted.ResultsAmong the 13,445 individuals in the sample, 20.42% had a severe headache or migraine. In fully adjusted models, dietary vitamin C consumption was substantially linked negatively with severe headache or migraine (odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.91–0.98, p = 0.0007). Compared to quartile 1, quartile 4 had 22% fewer odds of having a severe headache or migraine (OR = 0.78, 95% CI = 0.69–0.89, p = 0.0002). Subgroup analyses showed a significant difference between vitamin C intake and severe headaches or migraines by gender (p for interaction < 0.01).ConclusionReduced risk of severe headaches or migraines may be associated with increased consumption of vitamin C.

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Section: Discussionmentioning

confidence: 99%

Association of dietary vitamin C consumption with severe headache or migraine among adults: a cross-sectional study of NHANES 1999–2004

Zheng,

Jin,

Wei

et al. 2024

Front. Nutr.

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“…1 B). Microglias are multifunctional macrophages that settle in the brain, and astrocytes are considered neuronal support cells [ 24 , 25 ]. Astrocytes originate from neural stem cells in the subventricular zone during development and migrate along radial glial cell projections into the central nervous system (CNS) [ 26 ].…”

Section: Astrocytes: Not Only Supporting Cells For Neuronsmentioning

confidence: 99%

“…Astrocytes take up excess potassium ions released into the extracellular space during neuronal excitation and diffuse rapidly through intercellular gap junctions, preventing the significant rise of K + concentration around excitable neurons. Traditionally, astrocytes have been widely distributed, and they encircle neurons to support and isolate them [ 25 ]. However, an astrocyte has recently been shown to continuously exchange information with multiple neurons and is vital in the development, normal physiology, and pathology of the CNS [ 31 ].…”

Section: Astrocytes: Not Only Supporting Cells For Neuronsmentioning

confidence: 99%

The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review

Yang,

Ren,

Pan

et al. 2024

Pain Ther

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Cortical spreading depression (CSD) is a slow wave of cortical depolarization closely associated with migraines with an aura. Previously, it was thought that CSD depolarization was mainly driven by neurons, with characteristic changes in neuronal swelling and increased extracellular potassium (K + ) and glutamate. However, the role of astrocytes, a member of the neurovascular unit, in migraine with CSD has recently received increasing attention. In the early stages of CSD, astrocytes provide neurons with energy support and clear K + and glutamate from synaptic gaps. However, in the late stages of CSD, astrocytes release large amounts of lactic acid to exacerbate hypoxia when the energy demand exceeds the astrocytes’ compensatory capacity. Astrocyte endfoot swelling is a characteristic of CSD, and neurons are not similarly altered. It is primarily due to K + influx and abnormally active calcium (Ca 2+ ) signaling. Aquaporin 4 (AQP-4) only mediates K + influx and has little role as an aquaporin. Astrocytes endfoot swelling causes perivascular space closure, slowing the glymphatic system flow and exacerbating neuroinflammation, leading to persistent CSD. Astrocytes are double-edged swords in migraine with CSD and may be potential targets for CSD interventions.

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“…Inhibition of ROS may have therapeutic benefits in the prevention of migraine. Antioxidants may become a potential drug for migraine treatment ( Li et al, 2022 ). Under normal physiological conditions, oxygen free radicals are catalyzed by antioxidant factors such as SOD and glutathione peroxidase (GPX) to form water, which keeps intracellular ROS at a harmless low level.…”

Section: Relationship Between Reactive Oxygen Species and Migrainementioning

confidence: 99%

Energy metabolism disturbance in migraine: From a mitochondrial point of view

Wang

Yue

et al. 2023

Front. Physiol.

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Migraine is a serious central nervous system disease with a high incidence rate. Its pathogenesis is very complex, which brings great difficulties for clinical treatment. Recently, many studies have revealed that mitochondrial dysfunction may play a key role in migraine, which affects the hyperosmotic of Ca2+, the excessive production of free radicals, the decrease of mitochondrial membrane potential, the imbalance of mPTP opening and closing, and the decrease of oxidative phosphorylation level, which leads to neuronal energy exhaustion and apoptosis, and finally lessens the pain threshold and migraine attack. This article mainly introduces cortical spreading depression, a pathogenesis of migraine, and then damages the related function of mitochondria, which leads to migraine. Oxidative phosphorylation and the tricarboxylic acid cycle are the main ways to provide energy for the body. 95 percent of the energy needed for cell survival is provided by the mitochondrial respiratory chain. At the same time, hypoxia can lead to cell death and migraine. The pathological opening of the mitochondrial permeability transition pore can promote the interaction between pro-apoptotic protein and mitochondrial, destroy the structure of mPTP, and further lead to cell death. The increase of mPTP permeability can promote the accumulation of reactive oxygen species, which leads to a series of changes in the expression of proteins related to energy metabolism. Both Nitric oxide and Calcitonin gene-related peptide are closely related to the attack of migraine. Recent studies have shown that changes in their contents can also affect the energy metabolism of the body, so this paper reviews the above mechanisms and discusses the mechanism of brain energy metabolism of migraine, to provide new strategies for the prevention and treatment of migraine and promote the development of individualized and accurate treatment of migraine.

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Energy Metabolic Disorder of Astrocytes May Be an Inducer of Migraine Attack

Cited by 6 publications

References 46 publications

Association of dietary vitamin C consumption with severe headache or migraine among adults: a cross-sectional study of NHANES 1999–2004

Association of dietary vitamin C consumption with severe headache or migraine among adults: a cross-sectional study of NHANES 1999–2004

The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review

Energy metabolism disturbance in migraine: From a mitochondrial point of view

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