1992
DOI: 10.1016/0005-2728(92)90084-f
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Energy metabolism in islets of Langerhans

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Cited by 114 publications
(113 citation statements)
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“…Islet cells have many similarities to neurons [30,31], one being their high energy dependence on mitochondrial oxphos [31]. In particular, beta cells require mitochondrial ATP to sustain the production and release of insulin [31][32][33][34].…”
Section: Critical Effects Of Oxidative Phosphorylation Deficiencymentioning
confidence: 99%
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“…Islet cells have many similarities to neurons [30,31], one being their high energy dependence on mitochondrial oxphos [31]. In particular, beta cells require mitochondrial ATP to sustain the production and release of insulin [31][32][33][34].…”
Section: Critical Effects Of Oxidative Phosphorylation Deficiencymentioning
confidence: 99%
“…In particular, beta cells require mitochondrial ATP to sustain the production and release of insulin [31][32][33][34]. Indeed, the increase of intracellular ATP which is stimulated by a high blood glucose level is the signal for insulin release via a block of potassium channels in the plasma membrane of the beta cells [32][33][34].…”
Section: Critical Effects Of Oxidative Phosphorylation Deficiencymentioning
confidence: 99%
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“…11,12 Furthermore, dead cells are rapidly depleted of their ADP and ATP. 6,8,9,13 If dead cells are rapidly depleted of their ADP and ATP content, then the ADP/ATP ratio would be incapable of accounting for any dead cells found within an islet preparation and would be effectively overestimating the viability of the preparation.…”
mentioning
confidence: 99%
“…ADP and GDP, are known to stimulate K ATP channel activity in the presence of inhibitory concentrations of ATP [4,5]. Most studies have concentrated on the effects of ADP since the concentrations of ATP and ADP change reciprocally in response to glucose metabolism [6]. In the intact beta cell the ratio of ATP/ADP is considered more important than ATP alone in the regulation of K ATP channel activity and thereby in the control of beta-cell membrane potential.…”
mentioning
confidence: 99%