Energy partitioning in the surface-induced dissociation of linear and cyclic protonated peptides at an organic surface

Schultz, David G.; Lim, H.; Garbis, Spiros D.; Hanley, Luke

doi:10.1002/(sici)1096-9888(199903)34:3<217::aid-jms797>3.0.co;2-r

Cited by 31 publications

(51 citation statements)

References 35 publications

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“…These observations are in agreement with our previous results 38 and with results obtained by others. 21 Product ions C 6 H 4 + (m/z ) 76) and C 5 H 3 + (m/z ) 63) were observed in both of our previous experiments on the prototype Finnigan FTMS-2000 SID instrument 37,38 and in the present work. However, these ions were not major spectral features and did not exhibit pronounced dependence on collision energy.…”

Section: Parent Ion Preparationsupporting

confidence: 77%

“…This observation seems to be in contradiction with results from other groups that reported substantially higher kinetic energies of recoiled ions. 18,21 However, these studies report the velocity vector of recoiling ions, rather than V ⊥ . In contrast with the velocity component parallel to the surface (V | ) that depends linearly on the V | of projectile ions, V ⊥ varies very slowly with collision energy.…”

Section: Parent Ion Preparationmentioning

confidence: 99%

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Surface-Induced Dissociation of the Benzene Molecular Cation in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

2002

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Energy transfer in collisions of benzene molecular ions with a fluorinated self-assembled monolayer surface at normal incidence was studied over the range of collision energies from 0 to 75 eV in a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS). Rice-Ramsperger-Kassel-Marcus (RRKM) theory was used to calculate breakdown graphs for a simplified decomposition scheme of benzene on the time scale of ICR MS detection. Statistical partitioning of excess internal energy between the neutral and the ionic products was included in the theoretical model. Internal energy distributions of the predissociating parent ions were iteratively calculated using the recursive internal energy distribution search (RIEDS) method for each collision energy. On the basis of the above measurements, the collision-energy-dependent E SID f E int energy conversion efficiency was found to maximize at about 19.5% under the conditions of 31 eV SID collision energy.

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Section: Parent Ion Preparationsupporting

confidence: 77%

Section: Parent Ion Preparationmentioning

confidence: 99%

Surface-Induced Dissociation of the Benzene Molecular Cation in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

2002

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“…Hanley and colleagues [108], who used an axial energy analyzer to measure the kinetic energy distributions of fragment ions, determined that peptide dissociation occurs away from the surface rather than during direct surface contact. In contrast to small-ion SID, in which evidence of shattering was provided by the scattering of products with different velocities but similar energies [109], peptide fragments were shown to possess a common velocity.…”

Section: Kinetics Of Peptide Fragmentationmentioning

confidence: 99%

Surface-induced dissociation of small molecules, peptides, and non-covalent protein complexes

Wysocki

Joyce

Jones

et al. 2008

J. Am. Soc. Mass Spectrom.

130

138

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This article provides a perspective on collisions of ions with surfaces, including surfaceinduced dissociation (SID) and reactive ion scattering spectrometry (RISS). The content is organized into sections on surface-induced dissociation of small ions, surface characterization of organic thin films by collision of well-characterized ions into surfaces, the use of SID to probe peptide fragmentation, and the dissociation of large non-covalent complexes by SID. Examples are given from the literature with a focus on experiments from the authors' laboratory. The article is not a comprehensive review but is designed to provide the reader with an overview of the types of results possible by collisions of ions into surfaces. (J Am Soc Mass Spectrom 2008, 19, 190 -208) © 2008 American Society for Mass Spectrometry T andem mass spectrometry (MS/MS) is an essential tool for elucidating ion structure. The MS/MS experiment involves mass selection of a precursor ion followed by ion activation and subsequent dissociation. The ion activation step is commonly accomplished via collision-induced dissociation (CID) in which the initial kinetic energy of a projectile ion is converted into internal energy through inelastic collisions with a neutral gas. Several alternative activation methods have been used in tandem mass spectrometry, one of which is surfaceinduced dissociation (SID). SID is analogous to CID, except that a surface replaces the neutral gas as the collision target. A typical ion-surface collision event is illustrated in Figure 1.The incorporation of a surface into a mass spectrometer for ion activation was pioneered in the laboratory of R. Graham Cooks in the mid-1970s and early 1980s [1][2][3]. Since that time, collisions of lowenergy (eV) organic ions with surfaces within the tandem mass spectrometer have been valuable for analyzing surface composition, characterizing reactions between organic projectile ions and surface adsorbates, chemically modifying surfaces, and determining projectile ion structure. A major motivation for development of SID is that energy transfer to ionic projectiles can be improved by increasing the mass of the collision target. The total available energy for transfer into the internal modes of the projectile ion is defined by the center-of-mass energy (E COM ) described by eq 1:where E LAB is the laboratory collision energy and M ION and M N are the masses of the projectile ion and neutral, respectively. Energy transfer in CID is limited by the mass of the collision partner, typically inert gases such as helium, argon, or xenon. In SID, if one assumes that the surface is an infinitely large collision partner, E COM becomes independent of mass and approaches the laboratory collision energy. The assumption that the entire surface can be viewed as the collision partner is not always valid, however, and there are instances where the mass of the terminal groups on the surface influence the amount of energy transfer [4,5]. Nonetheless, the use of a massive surface target should, in theory, provide ...

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“…They include chemical analysis via the identification of molecular ions through SID, including those generated from biological samples. 65,284 Also, there is potential for characterization of adsorbates and the derivatization of the outermost monolayer of a surface. Ion/surface reactions also have potential in the production of microdevices.…”

Section: A Materials Sciencementioning

confidence: 99%

Collisions of ions with surfaces at chemically relevant energies: Instrumentation and phenomena

Grill¹,

Shen²,

Evans³

et al. 2001

Review of Scientific Instruments

202

249

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Articles you may be interested inMeasuring the internal energies of species emitted from hypervelocity nanoprojectile impacts on surfaces using recalibrated benzylpyridinium probe ions High-energy ions and atoms sputtered and reflected from a magnetron source for deposition of magnetic thin films J. Vac. Sci. Technol. A 23, 671 (2005); 10. 1116/1.1943452 Surface induced dissociations of protonated ethanol monomer, dimer and trimer ions: Trimer break-down graph from the collision energy dependence of projectile fragmentation An overview of gaseous ion/surface collisions is presented, with special emphasis on the behavior of polyatomic projectile ions at hyperthermal collision energies ͑1-100 eV͒ and the instrumentation needed for such studies. The inelastic and reactive processes occurring during ion/surface collisions are described in terms of several archetypes, viz., elastic and quasielastic scattering, chemical sputtering leading to release of surface material, inelastic scattering leading to surface-induced dissociation ͑SID͒ of the projectile, ion/surface reactions, and soft landing. Parameters that are important in ion/surface interactions are discussed, including the interaction time, the conversion of translational to internal energy, the translational energies of the scattered ions, the effects of scattering angle, and the influence of the nature of the surface. Different types of tandem mass spectrometers, built specifically to study ion/surface collision phenomena, are discussed and the advantages and disadvantages of the individual designs are compared. The role of SID as a technique in bioanalytical mass spectrometry is illustrated and this inelastic collision experiment is compared and contrasted with gas-phase collision-induced dissociation, the standard method of tandem mass spectrometry. Special emphasis is placed on reactive scattering including the use of ion/surface reactions for surface chemical analysis and for surface chemical modification.

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Energy partitioning in the surface-induced dissociation of linear and cyclic protonated peptides at an organic surface

Cited by 31 publications

References 35 publications

Surface-Induced Dissociation of the Benzene Molecular Cation in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Surface-Induced Dissociation of the Benzene Molecular Cation in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Surface-induced dissociation of small molecules, peptides, and non-covalent protein complexes

Collisions of ions with surfaces at chemically relevant energies: Instrumentation and phenomena

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